DocumentsDate added
Original article
Devinder Singh Negi1, Pankaj Shrivastava2, Smruti Prava Das1,*
Affiliation:-
1Department of Chemistry, Ravenshaw University, Cuttack - 753003, Odisha, India
2DNA Fingerprinting Unit, State Forensic Science Laboratory, Sagar - 470001, Madhya Pradesh, India
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Chemistry, Ravenshaw University, Cuttack - 753003, Odisha, India
2. DNA Fingerprinting Unit, State Forensic Science Laboratory, Sagar - 470001, Madhya Pradesh, India
Address reprint requests to
Dr.Smruti Prava Das.
Department of Chemistry, Ravenshaw University, Cuttack - 753003, Odisha, India
Article citation:
Negi DS, Shrivastava P, Das SP. Microsatellite markers alleles analysis in 12 cases of paternity establishment by DNA Profiling. J Pharm Biomed Sci. 2014; 04(12):1057-1071. Available at www.jpbms.info
ABSTRACT
The paternity is established by examination of inherited alleles in the questioned child from the reference parent samples. The alleles for all examined microsatellite loci unambiguously assigned to the questioned child as maternal and paternal alleles. In this study, we have examined 11 family trios and 1 family with 4 trios and convincingly established the paternity in 12 cases by DNA profiling. This study present an extensive analysis of number of possible alleles, homozygous and heterozygous alleles, inheritance pattern of maternal and paternal alleles in child, paternity index and probability of paternity in all the 12 cases. The total numbers of alleles in 15 microsatellite loci are 182. The average percent numbers of homozygous and heterozygous loci were 21.63 and 78.37 respectively. The likelihood of first allele in the child inherited from mother and fathers were 6.8 and 8.2 respectively. The average cumulative paternity index and probability of paternity were 1124182187 and 0.999999859 respectively in all the 12 cases. The analysis of STR alleles of microsatellite markers inferred the high heterozygosity, around equal chance that first inherited allele is from either parent, and high average values of cumulative paternity index and probability of paternity. The sample size of 12 cases wherein 15 trio are examined exhibited the robustness, efficiency and accuracy of markers with high diverse allele pool for establishment of paternity. The study showed the application of allele frequency database of Indian population, probability value and statistical methods in paternity establishment cases.
KEYWORDS: microsatellite, alleles; homozygosity; heterozygosity; paternity index; probability.
REFERENCES
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2014 Negi DS, Shrivastava P, Das SP. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article
Nádia Nara Rolim Lima1,*, Camilla Barros Meireles2, Lais Chaves Maia2, Matheus Felipe Aguiar Santos2, Florido Sampaio das Neves Peixoto1, Modesto Leite Rolim Neto1,2, Vânia Barbosa do Nascimento1.
Affiliation:-
1Postgraduate Program in Health Science. Faculty of Medicine of ABC, Santo André, São Paulo, Brazil
2Faculty of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil
The name of the department(s) and institution(s) to which the work should be attributed:
1.Postgraduate Program in Health Science. Faculty of Medicine of ABC, Santo André, São Paulo, Brazil
2.Faculty of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil
Address reprint requests to
Nádia Nara Rolim Lima.
Postgraduate Program in Health Science. Faculty of Medicine of ABC, Santo André, São Paulo, Brazil
Article citation:
Rolim Lima NN,Meireles CB,Maia LC,Aguiar Santos MF,Neves Peixoto FS,Rolim-Neta ML, et al. Conceptual Maps of the mental health of children and adolescents: A systematic review and meta-cognitive procedures in the architecture information in Northeastern of Brazil. J Pharm Biomed Sci. 2014; 04(12):1112-1127. Available at www.jpbms.info
ABSTRACT
Introduction: The Northeast Region is the third largest region of Brazil, with 49 million inhabitants, almost 30% of the population, being the second most populated region in the country, behind only Southeast. Investments related to mental health in the Northeast are increasing by the Federal Government. Despite huge investments directed to care to affective disorders, significant losses still occur. Our goal was to address the peculiarities of the evolutionary process of mental health in Brazil and in the Northeast, focusing on the juvenile age group. Method: Original analyzes were performed on secondary data from the Hospital Information System (SIH) belonging to the Unified Health System (SUS) in Brazil, Primary Care Information System (SIAB) and the Brazilian Institute of Geography and Statistics (IBGE). The original data of juvenile mental health were complemented by through the information mapping (Cmap Tools) in the databases: LILACS, SciELO, VHL, MEDLINE. Results: In the Northeast, the precarious socioeconomic conditions contribute to the involvement of children and adolescents with psychopathology. Between 2008 and August 2011, 470 deaths were recorded in mental health in the Northeast. This shows us that not only just create Center for Psychosocial Care-CAPS to improve instantly the health indicators, is still a need for greater training of health professionals who are involved in treating these patients. Conclusions: Some challenges remain in mental health, such as promoting care network, domain and expansion of diagnostic and therapeutic resources, stimulating the social rehabilitation of psychiatric patients, joint approach to mental and socioeconomic status, training of health professionals and interventions in respect to autonomy and the individuality of the bearer of affective disorder.
KEYWORDS: Affective Disorders; Mental Health; Juvenile.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014. Rolim Lima NN, Meireles CB, Maia LC, Aguiar Santos MF, Neves Peixoto FS, Rolim-Neto ML et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Vijaya Mahanth Prasad.K 1,*,Vijay Mahantesh Sunkad 2,Jyothi Gopal3,Chethana. K.V4
Affiliation:-
1,2Senior Resident, Department of Orthopedics, 3Senior Resident, Department of Anesthesia, 4Post Graduate, Department of Community Medicine,Navodaya Medical College Hospital, Raichur, Karnataka, India
The name of the department(s) and institution(s) to which the work should be attributed:
Navodaya Medical College Hospital, Raichur, Karnataka, India
Address reprint requests to
Dr Vijay Mahantesh.
Senior Resident, Department of Orthopedics, Navodaya Medical College Hospital, Raichur, Karnataka, India
Article citation:
Prasad VM, Sunkad VM, Gopal J, Chetnana KV. Functional outcome of fracture neck femur treated with bipolar hemiarthroplasty. J Pharm Biomed Sci. 2014;04(12):1050-1056. Available at www.jpbms.info
ABSTRACT
Background: Hip fractures are common and comprise about 20% of the operative workload of an orthopedic trauma unit. Intracapsular femoral neck fractures account for about 50% of all hip fractures. The objective of treatment of femoral neck fractures in the mobile elderly population is the early restoration of premorbid walking ability and quality of life. Hemiarthroplasty (Unipolar or Bipolar) is the most common treatment for displaced fractures of the femoral neck in the elderly and is associated with better functional outcome and fewer reoperations than internal fixation.
Aims and Objectives: To study the results of bipolar prosthesis with respect to pain, mobility and stability.
Methodology: The present study was conducted in the department of Orthopaedics, on patients who had sustained an intracapsular femoral neck fractures during the period of October 2011 to October 2012.
Results: The average age of the patients was 70.4years. The size of the prosthesis used varied from 39 mm to 49 mm. The fracture was managed by Bipolar hemiarthroplasty, we have excellent results in 10 cases (33.33%), good in 11cases (36.67%), fair in 7 cases (22.33%) and poor in two cases (6.67%) according to the Harris hip rating system. The pain was analysed at 6 weeks, 3 months and 6 months follow up according to Visual analogue scale (VAS). At 6 months follow up period, 70 % patients had no pain (0), 20 % had mild pain (1-4), 6.67 % moderate pain (5-8) and 3.33 % severe pain (>8).
KEYWORDS: Hip fractures; Bipolar hemiarthroplasty; Visual analogue scale.
REFERENCES
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6.Frihagen F, Nordsletten L, Madsen JE. Hemiarthroplasty or internal fixation for intracapsular displaced femoral neck fractures: randomised controlled trial. BMJ. 2007;335:1251–1254.
7.Parker MJ, Gurusamy K. Internal fixation versus arthroplasty for intracapsular proximal femoral fractures in adults. Cochrane Database Syst Rev. 2006;4:CD001708.
8.Rogmark C, Johnell O. Primary arthroplasty is better than internal fixation of displaced femoral neck fractures: a meta-analysis of 14 randomized studies with 2,289 patients. Acta Orthop 2006; 77: 359-367.
9.Rogmark C, Carlsson A, Johnell O, Sembo I. Costs of internal fixation and arthroplasty for displaced femoral neck fractures: a randomized study of 68 patients. Acta Orthop Scand 2003; 74: 293-298.
10.Keating JF, Grant A, Masson M, et al. Randomized comparison of reduction and fixation, bipolar hemiarthroplasty, and total hip arthroplasty. Treatment of displaced intracapsular hip fractures in healthy older patients. J Bone Joint Surg (Am). 2006; 88: 249-260.
11.Ries;bipolar hemiarthroplasty for recurrent dislocation after THA a report of 3 cases Ries M D ,Wiedel J D Clin Orthop Relat Res 1992 Ray(278):121-7
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13.Mannarino F,Maples D,Colwill JC &Swanson AB,Bateman Bipolar Hip Arthroplasty;A Review of 44 cases.Orthopaedics 1986 March;9(3):357-60.
Source of support: None.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Prasad VM, Sunkad VM, Gopal J, Chetnana KV. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Sunil Kumar1,*, VaibhaoGabhane2, Sanjay K Diwan1
Affiliation:-
1Professor,2Resident, Department of Medicine, Jawaharlal Nehru Medical College, DMIMS (DU), Sawangi (Meghe), Wardha, Maharashtra, India.
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Medicine, Jawaharlal Nehru Medical College, DMIMS (DU), Sawangi (Meghe), Wardha, Maharashtra, India
Address reprint requests to
Sunil Kumar.
Professor, Department of Medicine, Jawaharlal Nehru Medical College, DMIMS (DU), Sawangi (Meghe), Wardha, Maharashtra, India
Article citation: Kumar S, Vaibhao GS, Sanjay DK. Leptospirosis induced acute kidney injury in elderly: It’s different?. J Pharm Biomed Sci.2014; 04(12):1103-1105. Available at www.jpbms.info
ABSTRACT:
Leptospirosis is very important zoonosis in the world. Patients are typically young men. Here we report a 68-year-old healthy elderly man presented to our hospital with flu like syndrome and acute kidney injury. Eventually, Ig M Antibody for leptospira was found positive. Antibiotic treatment is efficient in the early and late or severe phases. In this case early and daily hemodialysis leads to rapid recovery of the patient.
KEYWORDS: Leptospirosis, acute kidney injury, elderly.
REFERENCES
1.Vijayachari P, Sugunan AP, Shriram AN. Leptospirosis: an emerging global public health problem. J Biosci. 2008;33:557–656.
2.Kobayashi Y. Human leptospirosis: management and prognosis. J Postgrad Med.2005;51:201–4.
3.Gancheva G I. Leptospirosis in elderly patients. braz j infect dis. 2013;17(5):592–595.
4.Sambasiva RR, Naveen G, Bhalla P, Agarwal SK. Leptospirosis in India and the rest of the world. Braz J Infect Dis. 2003;7:178-93.
5.Muthusethupathi M A, Shivakumar S, Vijayakumar R, Jayakumar M. Renal involvement in leptospirosis--our experience in Madras City. J Postgrad Med 1994;40:127
6.Abdulkader RCRM, Silva MV. The kidney in leptospirosis. PediatrNephrol 2008;23:2111-20.
7.Sitprija V, Losuwanrak K, Kanjanabuch T. Leptospiral nephropathy. SeminNephrol 2003;23:42-8.
8.L. Andrade, E. de Francesco Daher, A.C. Seguro. Seminars in Nephrology 2008;28(4):383-394.
Source of support: None.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Kumar S, Vaibhao GS, Sanjay DK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Sushma S Gore1, *, Sarang Tarak2
Affiliation:-
1Assistant Professor, Department of Obstetrics and Gynecology, Shri Vasantrao Naik Government Medical College Yavatmal, Maharashtra, India
2Consultant Paediatrician, Maharashtra, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Obstetrics and Gynecology, Shri Vasantrao Naik Government Medical College Yavatmal, Maharashtra, India
Address reprint requests to
Dr Sushma Gore.
C/o: Dr Prataprao Tarak
Marudra House, Shastri Nagar Society, Behind Date College Yavatmal: 445001 Maharashtra, India
Article citation:
Gore SS,Tarak S. A case report of fertility outcome after abdominal myomectomy in patient of uterine fibroids. J Pharm Biomed Sci. 2014;04(12):1097-1099. Available at www.jpbms.info
ABSTRACT
Uterine fibroids are the most common tumors of the female genital tract. Risk factors include nulliparity, obesity, family history, black race, and hypertension. Fibroids are estimated to be the sole cause of infertility in less than 3% of cases. In women desiring fertility who require treatment of fibroids, myomectomy is the preferred approach. Removal of cavity-distorting intramural and sub mucous myomas is generally recommended prior to proceeding with the infertility treatment. In this case report two intramural fibroids of 59х49х47 mm and 41х30 х 33mm and two small subserosal fibroid were found on ultrasonography which was the cause for infertility. Myomectomy was performed and after 9 months of myomectomy she conceived and delivered a live born boy, 2.75 kg in about 1 year of abdominal myomectomy.
KEYWORDS: Fibroid; infertility; myomectomy; uterine.
REFERENCES
1.Evans P, Brunsell S. Uterine fibroid tumors :diagnosis and treatment. Am Fam Physician. 2007 May 15;75(10):1503-1508.
2.Cynthia Farquhar. Do uterine fibroids cause infertility and should they be removed to increase fertility? BMJ 2009;338.
3.Bajekal N, Li TC. Fibroids, infertility and pregnancy wastage. Hum Reprod Update Dec;6(6):614-20.
4.Garcia CR, Tureck RW. Submucosal Leiomyomas and infertility. Fertil Steril 1984 42(1):16-9.
5.Dogra Y, Bagga R, Saha S. Successful Pregnancy Outcome Following Abdominal Myomectomy: A Case Report. Gynecol Obstet.2012;2:133. doi:10.4172/2161-0932.1000133.
Source of support: None.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Gore SS, Tarak S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.