DocumentsDate added
Original article
Hitesh R Ahir*,Niraj Kumar Biswas, Parimal H Patel, Mehul R Patel
Affiliation:-
Department of Microbiology, GMERS Medical College & Hospital, Valsad, Gujarat, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, GMERS Medical College & Hospital, Valsad, Gujarat, India
Address reprint requests to
Hitesh R Ahir,
Department of Microbiology GMERS Medical College & Hospital, Valsad, Gujarat, India
Article citation:
Ahir HR, Bisvas NK, Patel PH, Patel MR. Prevalence of Pseudomonas infection and its antibiotic susceptibility pattern isolated from various clinical samples at tertiary care hospital, Valsad, Gujarat. J Pharm Biomed Sci. 2014;04(12):1039-1041. Available at www.jpbms.info
ABSTRACT
Objectives: Pseudomonas is one of the important bacterial pathogens isolated from various clinical samples. Several studies indicate that resistance patterns are increasing nowadays. The present study was done to assess the Prevalence of Pseudomonas infection and antibiotic susceptibility pattern of pseudomonas isolated from various clinical samples.
Materials and Methods: A total of 697 samples were cultured out of them 71 pseudomonas isolates from different clinical samples, e.g. urine, pus.csf, sputum, and blood were tested for antibiotic susceptibility pattern using modified disk diffusion method as per Clinical and Laboratory Standards Institute guideline (CLSI)
Results: Prevalence of Pseudomonas infection is 10.18% detected at GMERS medical college and Hospital, Valsad, Gujarat, India. Major part of Pseudomonas isolates were detected from wounds.
Conclusion: Prevalence of Pseudomonas is higher in surgical patients and Multi-drug resistant isolates are also present in this institute.
KEYWORDS: Pseudomonas, Kirbey bour disk diffusion method, Antibiotic susceptibility pattern.
REFERENCES
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2014 Ahir HR, Biswas NK, Patel PH, Patel MR. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Amna Elhassan Hamad Mohammed1,*, Osama Yosuf Mohammed2, Sania A. Shaddad3,Ahmed Mohammed Ibrahim Hamad4
Affiliation:-
1Phd student, Department of Pharmacology, Medicinal and Aromatic Plant Research Institute, National Centre for Research, Sudan
2Co-supervisor, Department of Pharmacology, Faculty of Pharmacy, University of Mohammed Bin Saud-Riyadh
3Supervisor, Department of Medicine (Pharmacology) Faculty of Medicine, University of Khartoum, Sudan
4Physician of Internal Medicine, U.K. (Statistic analysis)
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Pharmacology, Medicinal and Aromatic Plant Research Institute, National Centre for Research, Sudan
2. Department of Pharmacology, Faculty of Pharmacy, University of Mohammed Bin Saud-Riyadh
3. Department of Medicine (Pharmacology) Faculty of Medicine, University of Khartoum, Sudan
Address reprint requests to
Dr. Amna Elhassan Hamad Mohammed.
Department of Pharmacology, Medicinal and Aromatic Plant Research Institute, National Centre for Research, Sudan
Article citation:
Mohammed Hamad AE, Mohammed OY, Sania Shaddad AI, Hamad Ibrahim AM. Anti-ulcerogenic activity of the crude methanolic extract of Solenostemma argel Hyne. J Pharm Biomed Sci.2014; 04(12):1084-1089. Available at www.jpbms.info
ABSTRACT
This study was carried out to evaluate the anti-ulcerogenic activity of the methanolic extract of Solenostemma argel Hyne to validate its traditional uses in treatment of stomach disturbances. The methanolic extract of Solenostemma argel Hyne herb was screened for its anti-ulcerogenic activity against induced-ulcer in four different models . The phytochemical studies of the plant showed that flavonoids, sterols, alkaloids, Triterpenes, Tannins, Saponins and Cuomarins are the main constituents. of the plant. The results showed that methanolic extract of S. argel Hyne at a dose of 300 mg ∕ kg was markedly decreased the incidence of ulcer that induced by aspirin in rat stomach and reduced ulcer index from 15.18±0.5 that induced by 150 mg/kg aspirin to 11.23±0.4. Also inhibited H+ ion concentration that had been stimulated by administration of histamine (2µg ∕kg) in rat stomach when the plant was given simultaneously at dose 400 µg ∕kg, with histamine and elevate the pH to 2.94±0.98 compared with the pH 2.25±1.09 that induced by administration of 2µg/ml histamine alone. Also S. argel Hyne extract antagonized ulcer induced by HCL/ethanol in mice by 37.9% ulcer inhibition, compared with 50.54% that of sucralfate.The extract reduced water immersion stress induced ulcer in rats by 73.74% ulcer inhibition whereas that of omeprazole was 100%. The results obtained from this study confirmed the antiulcerogenic activity of the methanolic extract of Solenostemma argel Hyne .
KEYWORDS: Anti-ulcer; Solenostemma argel Hyne; water immersion stress -induced ulcer.
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Source of support: None.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Mohammed Hamad AE, Mohammed OY, Sania Shaddad AI, Hamad Ibrahim AM. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.