DocumentsDate added
Original article
Amna Elhassan Hamad Mohammed1,*, Osama Yosuf Mohammed2, Sania A. Shaddad3,Ahmed Mohammed Ibrahim Hamad4
Affiliation:-
1Phd student, Department of Pharmacology, Medicinal and Aromatic Plant Research Institute, National Centre for Research, Sudan
2Co-supervisor, Department of Pharmacology, Faculty of Pharmacy, University of Mohammed Bin Saud-Riyadh
3Supervisor, Department of Medicine (Pharmacology) Faculty of Medicine, University of Khartoum, Sudan
4Physician of Internal Medicine, U.K. (Statistic analysis)
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Pharmacology, Medicinal and Aromatic Plant Research Institute, National Centre for Research, Sudan
2. Department of Pharmacology, Faculty of Pharmacy, University of Mohammed Bin Saud-Riyadh
3. Department of Medicine (Pharmacology) Faculty of Medicine, University of Khartoum, Sudan
Address reprint requests to
Dr. Amna Elhassan Hamad Mohammed.
Department of Pharmacology, Medicinal and Aromatic Plant Research Institute, National Centre for Research, Sudan
Article citation:
Mohammed Hamad AE, Mohammed OY, Sania Shaddad AI, Hamad Ibrahim AM. Anti-ulcerogenic activity of the crude methanolic extract of Solenostemma argel Hyne. J Pharm Biomed Sci.2014; 04(12):1084-1089. Available at www.jpbms.info
ABSTRACT
This study was carried out to evaluate the anti-ulcerogenic activity of the methanolic extract of Solenostemma argel Hyne to validate its traditional uses in treatment of stomach disturbances. The methanolic extract of Solenostemma argel Hyne herb was screened for its anti-ulcerogenic activity against induced-ulcer in four different models . The phytochemical studies of the plant showed that flavonoids, sterols, alkaloids, Triterpenes, Tannins, Saponins and Cuomarins are the main constituents. of the plant. The results showed that methanolic extract of S. argel Hyne at a dose of 300 mg ∕ kg was markedly decreased the incidence of ulcer that induced by aspirin in rat stomach and reduced ulcer index from 15.18±0.5 that induced by 150 mg/kg aspirin to 11.23±0.4. Also inhibited H+ ion concentration that had been stimulated by administration of histamine (2µg ∕kg) in rat stomach when the plant was given simultaneously at dose 400 µg ∕kg, with histamine and elevate the pH to 2.94±0.98 compared with the pH 2.25±1.09 that induced by administration of 2µg/ml histamine alone. Also S. argel Hyne extract antagonized ulcer induced by HCL/ethanol in mice by 37.9% ulcer inhibition, compared with 50.54% that of sucralfate.The extract reduced water immersion stress induced ulcer in rats by 73.74% ulcer inhibition whereas that of omeprazole was 100%. The results obtained from this study confirmed the antiulcerogenic activity of the methanolic extract of Solenostemma argel Hyne .
KEYWORDS: Anti-ulcer; Solenostemma argel Hyne; water immersion stress -induced ulcer.
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Source of support: None.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Mohammed Hamad AE, Mohammed OY, Sania Shaddad AI, Hamad Ibrahim AM. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article
Rahul Kumar Mishr1,*, Jitender Dhillon2, Rajesh Pandey3, K. S. Sodhi3, Jasbir Singh3
Affiliation:-
1 MSc MLT (Intern), 2MD Student, 3Professor (MD)
Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
Address reprint requests to
Rahul Kumar Mishr.
MSc MLT (Intern), Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India., India
Article citation:
Mishr RK, Dhillon J, Pandey R, Sodhi KS, Singh J. Quantum Dots In Medical Science. J Pharm Biomed Sci. 2014; 04(12):1042-1049. Available at www.jpbms.info
ABSTRACT:
Quantum dots (QDs) are tiny semiconductor crystals of size 1-10 nanometres made up of compounds from group II to VI and III to V. The exceptional photophysical properties of QDs, particularly photostability and emission as a function of size, make them superior to organic dyes for biological applications: microscopy and multiplexed histology, flow cytometry, drug delivery, photodynamic therapy, clinical imaging, real time detection of intracellular events etc. Thus, QDs and their alliance with other aspects of nanotechnology have opened new possibilities for advanced molecular and cellular imaging as well as for ultrasensitive bioassays, diagnostics and therapeutics. However, high-quality and well-controlled trials specifically addressing certain inherent pitfalls of QDs will need to be undertaken before these can be considered for human use.
KEYWORDS: Quantum dots; nanotechnology; medicine; diagnosis; therapy.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Mishr RK ,Dhillon J, Pandey R, Sodhi KS,Singh J. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Deepak Viswanath*, R.Hemalatha, Priya Nagar
Affiliation:-
1Professor and Head, 2Post Graduate Student, 3Reader, Department of Pedodontics and Preventive Dentistry, Krishnadevaraya College of Dental Sciences and Hospital, International airport road, Hunasamaranahalli, via Yelahanka SMVIT Post, Bangalore 562157, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Pedodontics and Preventive Dentistry
Krishnadevaraya College of Dental Sciences and Hospital, International airport road, Hunasamaranahalli, via Yelahanka SMVIT Post, Bangalore 562157, India
Address reprint requests to
Dr.Deepak Viswanath
Professor and Head Department of Pedodontics and Preventive Dentistry, Krishnadevaraya College of Dental Sciences and Hospital, International airport road, Hunasamaranahalli, via Yelahanka SMVIT Post, Bangalore 562157,India
Article citation:
Viswanath D, Hemalatha R, Nagar P. Forensic odontology- knowing the unknown- guidelines to general Dentists. J Pharm Biomed Sci. 2014; 04(12):1106-1111. Available at www.jpbms.info
ABSTRACT
A dentist caries a considerable responsibility since his scientific opinion is of great help when all other paths of forensic identification have been exhausted, a broad background knowledge of general dentistry, encompassing all dental specialties and basic knowledge of the role of the forensic pathologist and the methods used in autopsy is essential.
Forensic dentistry is a collaboration of law enforcement officials, forensic pathologists, forensic odontologists, forensic anthropathologists, serologists, criminalistics, & other specialists as per necessity. This gives article gives a in details explanation of the applications of forensic odontology like the identification of unknown decedents, recognition of victims of mass disasters, age estimation of both living and deceased including neo natal remains, analysis of bite marks and attack and weapon marks, investigation of family violence, contribution in anthropological and archaeological research and dental jurisprudence including expert witness testimony. In India, probably due to the lack of proper awareness, neither the government nor the people have completely understood the role that can be played by a forensic dentist.
KEYWORDS: Forensic Dentistry; Dental Identification; Dental Evidence.
REFERENCES
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2014. Deepak Viswanath, R.Hemalatha, Priya Nagar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Raquel Melo Vieira, Eudes Alves Simões Neto, José Mauricio Pereira Lopes, Raul Rodrigues Barros, Bernardo Nogueira Faé, Jucier Gonçalves Junior, Modesto Leite Rolim Neto*, Maria do Socorro Vieira dos Santos*, Claudio Gleidiston Lima da Silva*, Regis Santana Figueiredo**
Affiliation:-
* Faculty of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil
** Faculty of Medicine, Estacio - FMJ, Juazeiro do Norte, Ceará, Brazil
The name of the department(s) and institution(s) to which the work should be attributed:
1. Faculty of Medicine,Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil
2. Faculty of Medicine, Estacio - FMJ, Juazeiro do Norte, Ceará, Brazil
Address reprint requests to
Maria do Socorro Vieira dos Santos.
284, Divine Savior Street, Downtown, Barbalha, Ceará, Brazil, 63180000.
Phone Number: +055(88)98214066
ABSTRACT:
Background: Diabetes and HIV infection are common co-morbid conditions of disseminated Histoplasmosis. Case report: This study reports a case of disseminated histoplasmosis in a 4 year old boy with type 1 diabetes mellitus history diagnosed a year before. He was admitted with high fever and cough in pediatric emergency. The child evaluated with more productive cough, hepatosplenomegaly, generalized painful lymph node, whitish plaques in the oral cavity, angular cheilitis and ocular disease (erythema in the sclera and bilateral conjunctiva, leftmost). Diagnosis was based on histopathological examination, culture, bacterioscopy and PCR. Despites the adequate treatment, patient developed blinds in the left eye. Conclusion: After all, we conclude that histoplasmosis became an important public health problem due to the high number of immunocompromised patients, what makes it important the attention on differential diagnosis.
KEYWORDS: Case Report; Child preschool; Histoplasmosis; Type 1 Diabetes Mellitus.
Article citation:
Raquel Melo Vieira, Eudes Alves Simões Neto, José Mauricio Pereira Lopes, Raul Rodrigues Barros, Bernardo Nogueira Faé, Jucier Gonçalves Junior, et al. Disseminated Histoplasmosis in the Child With Diabetes Mellitus: Case Report. J Pharm Biomed Sci 2014; 04(12):1153-1159.
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23.Adenis, A.A., Aznar, C., Couppié, P.Histoplasmosis in HIV-Infected Patients: A Review of New Developments and Remaining Gaps. Curr Trop Med Rep. 2014; 1(2): 119–128.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014. Raquel Melo Vieira, Eudes Alves Simões Neto, José Mauricio Pereira Lopes, Raul Rodrigues Barros, Bernardo Nogueira Faé, Jucier Gonçalves Junior, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Hitesh R Ahir*,Niraj Kumar Biswas, Parimal H Patel, Mehul R Patel
Affiliation:-
Department of Microbiology, GMERS Medical College & Hospital, Valsad, Gujarat, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, GMERS Medical College & Hospital, Valsad, Gujarat, India
Address reprint requests to
Hitesh R Ahir,
Department of Microbiology GMERS Medical College & Hospital, Valsad, Gujarat, India
Article citation:
Ahir HR, Bisvas NK, Patel PH, Patel MR. Prevalence of Pseudomonas infection and its antibiotic susceptibility pattern isolated from various clinical samples at tertiary care hospital, Valsad, Gujarat. J Pharm Biomed Sci. 2014;04(12):1039-1041. Available at www.jpbms.info
ABSTRACT
Objectives: Pseudomonas is one of the important bacterial pathogens isolated from various clinical samples. Several studies indicate that resistance patterns are increasing nowadays. The present study was done to assess the Prevalence of Pseudomonas infection and antibiotic susceptibility pattern of pseudomonas isolated from various clinical samples.
Materials and Methods: A total of 697 samples were cultured out of them 71 pseudomonas isolates from different clinical samples, e.g. urine, pus.csf, sputum, and blood were tested for antibiotic susceptibility pattern using modified disk diffusion method as per Clinical and Laboratory Standards Institute guideline (CLSI)
Results: Prevalence of Pseudomonas infection is 10.18% detected at GMERS medical college and Hospital, Valsad, Gujarat, India. Major part of Pseudomonas isolates were detected from wounds.
Conclusion: Prevalence of Pseudomonas is higher in surgical patients and Multi-drug resistant isolates are also present in this institute.
KEYWORDS: Pseudomonas, Kirbey bour disk diffusion method, Antibiotic susceptibility pattern.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2014 Ahir HR, Biswas NK, Patel PH, Patel MR. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.