DocumentsDate added
Review article
Uday Nandkishorji Soni1,*,Mayuresh J. Baheti1,Nandlal G. Toshniwal1¥
Affiliation:
1PG Student,1¥Professor and HOD, Department of Orthodontics and Dentofacial Orthopaedics, Rural Dental College, Pravara Institute of Medical Sciences, Loni – 413736,India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Orthodontics and Dentofacial Orthopaedics, Rural Dental College, Pravara Institute of Medical Sciences, Loni – 413736, India
Address reprint requests to
Dr. Uday Nandkishorji Soni.
Dept. of Orthodontics and Dentofacial Orthopaedics,
Rural Dental College, Pravara Institute of Medical Sciences, Loni–413736, India
Article citation: Soni UN,Baheti MJ,Toshniwal NG. Turmeric in dentistry – The hidden potential. J Pharm Biomed Sci.2015;05(01):84-89.Available at www.jpbms.info
ABSTRACT:
Turmeric has been used for thousands of years as a dye, a flavoring, and a medicinal herb. In India, it has been used traditionally as a remedy for stomach and liver ailments, as well as topically to heal sores. Ancient Indian medicine has touted turmeric as an herb with the ability to provide glow and luster to the skin as well as vigor and vitality to the entire body. The main component of turmeric is curcumin. The activity of curcumin derived from its complex chemistry as well as its ability to influence the multiple signalling pathways. Root part of the plant are widely used by different tribal communities as turmeric have been shown to have wide spectrum of biological actions, which include anti-inflammatory, anti-diabetic, analgesic, antibacterial, anti-fungal, anti-protozoal, anti-ulcer, hypocholesteremic activities. Its anti-cancer effect induced mainly mediated through induction of apoptosis and many more medicinal values.
This review article is to highlight the pharmacological action and its therapeutic role of turmeric in dentistry. This article is to illustrate the value of this medicinal spice and to emphasize to make an effective use of this in various dental applications.
KEYWORDS: Turmeric, Ayurveda, herbal medicine, Oral health.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the
manuscript represents honest and original work.
REFERENCES
1.Roberson T, Harald OH, Edward JS. Sturdevant's Art and Science of Operative Dentistry. 10th ed. Elsevier Health Sciences,Australia, 2006.
2.World Health Organization - Global Strategy On Diet, Physical Activity And Health Facts: Dental Diseases And Oral Health .WHO oral health publications, Geneva 2003.
3.Balkland L, Ingle J, Baumgartner C. Ingles Endodontics . 6th edition.PMPH , USA . 2010. pp114.
4.Rapeephan Nagasiri, Chitmongkolsuk MS. Long-term survival of endodontically treated molars without crown coverage: A retrospective cohort study.JPD2003;93(2):164-170.
5.Bairwa M, Rajput M, Sachdeva S. Modified kuppuswamy's socioeconomic scale: social researcher should include updated income criteria, 2012. Indian J Community Med 2013; 38:185-6.
6.Satheesh BH, Omar S. Replacement of Missing Anterior Teeth in a Patient with Temporomandibular Disorder. Case Reports in Dentistry. 2014;39: 4.
Source of funding: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Sisodia N,Yadav S,Nangia T,Singh P,Yadav M,Singh HP. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
J.O. Sule1,*, F.M. Onyije2 and G.E. Onoru1
Affiliation:-
1Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Bayelsa State, Nigeria
2Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Bayelsa State, Nigeria.
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Bayelsa State, Nigeria
2.Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Bayelsa State, Nigeria.
Address reprint requests to
J.O Sule.
Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island,Yenagoa, Bayelsa State, Nigeria
Article citation:
Sule JO, Onyije FM, Onoru GE. The effects of Irvingia gabonensis (Bush mango) flesh and seed extracts on the biochemical and histological parameters of the liver in Wistar albino rats. J Pharm Biomed Sci.2015;05(01):25-30.Available at www.jpbms.info
ABSTRACT
Objective: To evaluate the biochemical and histological effects of Irvingia gabonensis (seeds and flesh) on the liver of male albino rats.
Materials and Methods: Twenty five male albino rats were divided into five groups (1-5), with five rats in each group in a completely randomized design. The treatment regime for the groups were; groups 1-2 received 0.8ml of normal saline, Group 3 received 200mg/Kgbw of I. gabonensis seed extract, Group 4 received 200mg/Kgbw of I. gabonensis flesh extract and Group 5 received 200mg/Kgbw of vitamin E. The treatment was administered once daily by oral intubation for 21 days. After which groups (2-5) received a single dose of 200mg/Kgbw acetaminophen.
Results: There is significant increase (p≤0.05) in the level of AST (44.73± 3.72) in untreated group when compared the treated groups (43.48±1.3 and 43.13± 5.02) for seed and flesh extracts respectively. ALT (18.60± 1.11) in seed extracts was not significantly different from the control (18.35 ± 1.34) but there was a significant decrease when compared with the standard group (19.08± 0.59). However, the flesh extract showed significant increase in the ALT (23.35± 3.88) when compared with the control. The levels of total protein decreased significantly in rat groups pretreated with seed extracts (54.80± 2.67) when compared with the negative control (58.87± 1.98). Also, level of total protein significantly increased (p≤0.05) in rat group pretreated with flesh extract when compared with the negative control. There is no significant difference in the levels of ALP in pretreated rat groups and the control. Photomicrographs of liver showed mild to severe degenerative effects on the histology of the liver investigated. Some of the histopathological effects observed in the liver were partial radial appearance from the Portal triad, total loss of radial appearance from the central vein, sinusoidal dilatation around the portal triad, congestion of portal triad with inflammatory cells, loss of radial appearance and distortion of tissue architecture.
Conclusion: This study provides evidence that I. gabonensis (seeds and flesh) consumption should be with caution.
KEYWORDS: I. gabonensis; Bush mango; Histology; Portal triad; Aminotransferase; BW (Body weight).
Source of support: None.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
REFERENCES
1.Matos L, Nzikou JM, Matouba E, Pandzou-Yembe V N, Mapepoulou TG, Linder M, Desobry S. Studies of Irvingia gabonensisseeds kernels: Oil technological applications. Pak. J, Nutr. 2009 8: 151-157
2.Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CMF, Oben JE.(http://creativecommons.org/licenses/by/2.0) 2009
3.Tchoundjeu Z, Atangana AR. Irvingia gabonensis (Aubry-LecomteexO’Rorke) Baill.Record from Protabase.van der Vossen HAM and Mkamilo G.S (editors). PROTA (Plant Resources of Tropical Africa / Ressources végétalesdel’ Afriquetropicale), Wageningen, The Netherland: http://database.prota.org/ search.htm. 2007
4.Nosiri I, Abdu-Aguye I, Hussaini MI, Abdurahaman E. Leaf Extracts Of Irvingia Gabonensis Increase Urine Output And Electrolytes In Rats. The Internet Journal of Alternative Medicine. 2011 ,8 : 2.
5.Ngondi JL, Oben JE, Minka SR. The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon. Lipids in health and Disease 2005; 4, 12-15.
6.Fajimi O, Sarumi MB, Olayode MN, Gamra EO, Sanusi SI. In vitro propagation of Irvingia gabonensis. African journal of biotechnology, 2007; 6(8): 976-978.
7.Bergemeyer HU, Bent E. Glutamate-oxaloacetate transaminase, glutamate pyruvate transaminase. In: Methods of Enzymatic Analysis (Bergmeyer HU, ed.), Academic Press, New York, 1963; 837–852.
8.Garen A, Levinthal C. A fine-structure genetic and chemical study of the enzyme alkaline phosphatase from E. coli. Purification and characterization of alkaline phosphatase. Biochim Biophys Acta, 1960; 38, 470–483.
9.Baker JF, Silverton ER. Kishaw D. Introduction to Medical Laboratory Technology, Butter worths, London, 1985; 316-369.
10.Smith GS, Nadig DE, Kokoska ER, Solomon H, Tiniakos DG, Miller TA. Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats. J. Surg. Res, 1998; 80, 252-258.
11.Edwards, CRW, Bouchier IAD, Haslet C, Chilvers ER. Davidson’s Principlesand practice of Medicine, 17th edn. Churchill Livingstone, 1995; 488 – 490.
12.Abatan MO, Arowolo ROA, Olorunsogo O. Pathological Effects of Lantana camara and Dichapet alummada gascasiense in Goats. Trop. Vet. Med, 1996; 14, 127 – 132.
13.Ojiakor OA, Nwanjo HU. Is Vernonia amygdalina hepatotoxic or hepatoprotective? Answers from biochemical and toxiclogical studies in rats. Afr. J. Biotechnol, 2006; 5(18), 1648-1651.
14.Ojekale AB, Ojiakor O A, Saibu GM, Lala A, Olodude OA. Long term effects of aqueous stem bark extract of Cissuspopulnea (Guill. and Per.) on some biochemical parameters in normal rabbits. Afr. J. Biotechnol., 2007; 6(3), 247-251.
15.Lambert JD, Sang S, Yang CS. Possible controversy over dietary polyphenols: Benefits vs risks. Chem. Res. Toxicol, 2007; 20(4), 583-585.
16.Adeline YL, Ignacio LS, Srikumar C, Sufyan A, Judson JP. Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.BMC Pharmacology , 2010; 10:14
17.Rivera L, Moron R, Sánchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity 2008 ;16: 2081-7
18.Mukai K. Synthesis and Kinetic Study of Antioxidant and Prooxidant Actions of Vitamin E Derivates. In: Packer, L. and J. Fuchs, (Eds.), Vitamin E in Health and Disease. Marcel Dekker New York, 1993: 97-119.
19.Thomas SR, Neuzil J, Stocker R. Cosupplementation with coenzyme Q prevents the prooxidant effect of α-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation. Arterioscler.Thromb.Vasc.Biol, 1996; 16, 687-696. 20.Eder K, Flader D, Hirche F, Brandsch C. Nutrient interactions and toxicity: Excess dietary vitamin E lowers the activities of antioxidative enzymes in erythrocytes of rats fed salmon oil. J. Nutr.,2002; 132: 3400-3404.
21.Ladipo DO, Foundun JM, GanagaN. Domestication of bush mango (irvingiagabonensis): some exploitable intraspecific variations in west and central Africa. Food and agriculture organization, Rome. Italy. 1996
22.Ainge L, Brown N. Irvingia gabonensis and Irvingia wombolu.A State of Knowledge Report undertaken for The Central African Regional Program for the Environment. Oxford Forestry Institute. Department of Plant Sciences.University of Oxford. United Kingdom. 2001
23.Albert A. Irvingiagabonensis(African/Bush mango).Global Institute for BioExploration – Gibex. 2010
24.Rosen HR, Keefe EB. Evaluation of abnormal liver enzymes, use of liver tests and the serology of viral hepatitis: Liverdisease, diagnosis and management. 1st Ed. New York; Churchill livingstone publishers, 2000; 24-35.
Copyright © 2014 Sule JO, Onyije FM, Onoru GE. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Neha Sisodia1,Sharda Yadav1,Tanu Nangia2,Preetinder Singh3,*,Manisha Yadav4,HP Singh5
Affiliation:
1Senior Resident (Dental), Dr RML Hospital, New Delhi, India
2Reader, ITS Dental College, Greater Noida, India
3Associate Professor (Periodontics), Swami Devi Dayal Dental College, Barwala, Panchkula (Haryana), India
4Orthodontist, Dental solutions, Gurgaon, India
5Head of Department, Department of dentistry, Dr RML Hospital, New Delhi, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Senior Resident (Dental), Dr RML Hospital, New Delhi, India
2.Reader, ITS Dental College, Greater NOIDA, India
3.Assoc. Professor (Periodontics), Swami Devi Dayal Dental College, Barwala, Panchkula (Haryana),India
4.Orthodontist, Dental solutions, Gurgaon, India
5.Head of Department, Department of dentistry, Dr RML Hospital, New Delhi, India
Address reprint requests to
Dr .Preetinder Singh.
Associate Professor (Periodontics),
Swami Devi Dayal Dental College, Barwala, Panchkula (Haryana), India
Article citation:
Sisodia N,Yadav S,Nangia T,Singh P,Yadav M,Singh HP Dental Patients’ knowledge and attitude towards Endodontics – A survey. J Pharm Biomed Sci.2015;05(01):80-83.Available at www.jpbms.info
ABSTRACT:
Aim: The purpose of this survey was to assess the level and sources of information about root canal treatment in patients visiting a tertiary care hospital in Delhi, India
Materials and methods: Patients’ knowledge and awareness about root canal treatment as an option to retain teeth were evaluated through a standardized questionnaire distributed to patients visiting the dental OPD. The questionnaires were distributed to the patients (n= 300) during their regular dental visits.
Results: The results of this study indicate that (52%) of the subjects knew about root canals. Multiple visits, High cost were the major factors preventing patients from choosing root canal treatment for management of a painful tooth over extraction.
Conclusion: The results of this survey showed a moderate level of awareness about root canal treatment among the selected sample of dental patients. It also highlighted the need for providing more information to the patients about the advantages of retaining teeth via Endodontic therapy..
KEYWORDS: Dentists; dental caries; Education, Questionnaire; Root canal therapy.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
REFERENCES
1.Roberson T, Harald OH, Edward JS. Sturdevant's Art and Science of Operative Dentistry. 10th ed. Elsevier Health Sciences,Australia, 2006.
2.World Health Organization - Global Strategy On Diet, Physical Activity And Health Facts: Dental Diseases And Oral Health .WHO oral health publications, Geneva 2003.
3.Balkland L, Ingle J, Baumgartner C. Ingles Endodontics . 6th edition.PMPH , USA . 2010. pp114.
4.Rapeephan Nagasiri, Chitmongkolsuk MS. Long-term survival of endodontically treated molars without crown coverage: A retrospective cohort study.JPD2003;93(2):164-170.
5.Bairwa M, Rajput M, Sachdeva S. Modified kuppuswamy's socioeconomic scale: social researcher should include updated income criteria, 2012. Indian J Community Med 2013; 38:185-6.
6.Satheesh BH, Omar S. Replacement of Missing Anterior Teeth in a Patient with Temporomandibular Disorder. Case Reports in Dentistry. 2014;39: 4.
Source of funding: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Sisodia N,Yadav S,Nangia T,Singh P,Yadav M,Singh HP. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article
Pankaj Aapaliya1,*, Surina Sinha,2 Lavina Sinha3, Vikas Malik4
Affiliation:-
1MDS, Post Graduate student, Department of Public Health Dentistry, Pacific Dental College and Hospital, Airport Road, Debari, Udaipur, Rajasthan, India
2MDS, Post Graduate student, Department of Orthodontics & Dentofacial Orthopaedics, Pacific Dental College and Hospital, Airport Road, Debari, Udaipur, Rajasthan, India
3MD, Post Graduate student, Department of Medicine, C U Shah Medical College, Surendranagar, Gujarat, India
4MDS, Associate Professor, Department of Orthodontics & Dentofacial Orthopaedics, SGT Dental College, Budhera, Gurgeon, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Public Health Dentistry, Pacific Dental College and Hospital, Airport Road, Debari, Udaipur, Rajasthan, India
2.Department of Medicine, C U Shah Medical College, Surendranagar, Gujarat, India
3.Department of Orthodontics & Dentofacial Orthopaedics, SGT Dental College, Budhera, Gurgeon, India
Address reprint requests to
Dr. Pankaj Aapaliya.
MDS, Post Graduate student,
Department of Public Health Dentistry,
Pacific Dental College and Hospital, Airport Road, Debari, Udaipur–313024,Rajasthan,India
Phone Number: +919428746380; Fax: +912942491508
Article citation:
Aapaliya P,Sinha S,Sinha L,Malik V. Ethno-dentistry: Tapping the potential of indigenous plants for therapeutic dentistry. J Pharm Biomed Sci. 2015; 05(01):31-38. Available at www.jpbms.info
ABSTRACT:
Oral diseases, including dental caries and periodontal diseases are major health problems worldwide. Oral health is integrated to the general quality of life that extends beyond the functions of the craniofacial complex. Traditional medicine can treat various infections and chronic conditions. Problems such as deformities of the oral cavity and oral infections were cured in ancient India. Ayurvedic medication been used for various ailments since immemorial time. Scientific validations of the Ayurveda in dental health practices could justify their incorporation into modern dental care. The ethnomedical system rooted in rich biodiversity associated knowledge, particularly in Asia is well known. Publicity of these systems would benefit the general population by imparting more confidence in the ancient practices. This review shows plants products are currently gaining attention for treatment of various ailments in dentistry.
KEYWORDS: Ethnomedicine; herbs; Plants; Oral disease.
REFERENCES
1.Sheiham A. Oral health, general health and quality of life. Bull World Health Organ. 2005;83(9):644.
2.Kanwar P, Sharma N, Rekha A. Medicinal plants use in traditional healthcare systems prevalent in Western Himalayas. Indian Journal of Traditional Knowledge. 2006;5:300-9.
3.Bapuji JL, Ratnam SV. Traditional uses of some medicinal plants by tribals of Gangaraju Madugula Mandal of Visakhapatnam district, Andhra Pradesh. Ethnobotanical Leaflets. 2009;13:388-98.
4.Sharma V, Joshi BD. Bio-diversity of medicinal plants in some selected areas of Almora district. J Env Bio Sci. 2008;22:39-42.
5.Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period of 1981–2002. Journal of Natural Products. 2003:66:1022–33.
6.Acharya D, Shrivastava A. Indigenous Herbal Medicines: Tribal Formulations and Traditional Herbal Practices. India: Aavishkar Publishers Distributor; 2008.
7.Mukherjee PK. Quality control of herbal drugs–an approach to evaluation of botanicals. Business Horizons, New Delhi, 2002.
8.Kshirsagar RD, Singh NP. Some less known ethnomedicinal uses from Mysore and Coorg districts, Karnataka state, India. J Ethnopharmacol. 2001;75:231-8.
9.Anyinam C. Ecology and ethnomedicine: Exploring links between current environmental crisis and indigenous medical practices. Soc Sci Med. 1995;40(3):321-9.
10.Gesler WM. Therapeutic landscapes: medical Issues in Light of the new cultural geography. Soc Sci Med. 1992;34(7):735-46.
11.Rai PK, Lalramnghinglova H. Threatened and less known ethnomedicinal plants of an Indo-Burma hotspot region: conservation implications. Environ Monit Assess. 2011;178(1-4):53-62.
12.Mukherjee PK, Suresh B, Verpoorte R. CNS active potentials of some Hypericum species of India. Phytomedicine. 2001;8:331−7.
13.Kumar V. Potential medicinal plants for CNS disorders: an overview. Phytother Res. 2006;20(12):1023-35.
14.Ali SS, Kasoju N, Luthra A, Singh A, Sharanabasava H, Sahu A, Bora U. Indian medicinal herbs as sources of antioxidants. Food Research International. 2008;4(1):1-15.
15.Bhatia AL, Jain M. Amaranthus paniculatus (Linn.) improves learning after radiation stress. J Ethnopharmacol. 2003; 85:73–9.
16.Nagpal M, Sood S. Role of curcumin in systemic and oral health: An overview. J Nat Sc Biol Med. 2013;4:3-7.
17.Kumaran A, Karunakaran RJ. In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India LWT. Food Science and Technology. 2007;40:344-52.
18.Neelakantan P, Jagannathan N, Nazar N. Ethnopharmacological approach in endodontic treatment: a focused review. International Journal of Drug Development and Research. 2011;3(4):68-77.
19.Pandranki J, Rao NV, Vijayalakshmib G, Dorothy K. Ethnobotanical approach against resistant endodontic pathogens using Morinda Species–an antimicrobial study. Int J Biol Med Res. 2013;4(4):3661-6.
20.Sawangjaroen N, Phongpaichit S, Subhadhirasakul S, Visutthi S, Srisuwan N, Thammapalerd N. The anti-amoebic activity of some medicinal plants used by AIDS patients in southern Thailand. Parasitol Res. 2006;98(6):588-92.
21.Katewa SS. Indigenous people and forests: Perspectives of an ethnobotanical study from Rajasthan (India). Herbal Drugs: Ethnomedicine to modern medicine. 2009;33-56.
22.Jagtap SD, Deokule SS, Bhosle SV. Some unique ethnomedicinal uses of plants used by the Korku tribe of Amravati district of Maharashtra, India. J Ethnopharmacol. 2006;107(3):463-9.
23.Pattanaik C, Reddy CS. Medicinal plant wealth of local communities in Kuldiha Wildlife Sanctuary, Orissa, India. Journal of Herbs, Spices and Medicinal Plants 2008; 14(3):175-184.
24.Global Market Global Herbal Market - Department of Indian System of Medicine. Available at www.dsir.gov.in/reports/ittp_tedo/ism/ISM_AS_Market.pdf.
25.Sharma A, Shanker C, Tyagi LK, Singh M, Rao ChV. Herbal medicine for market potential in India: an overview. Academic Journal of Plant Sciences. 2008;1(2):26-36.
26.Dhar U, Rawal RS, Upreti J. Setting priorities for conservation of medicinal plants-A case study in the Indian Himalaya. Biological Conservation 2000; 95: 57-65. DOI:10.1016/S0006-3207(00)00010-0.
27.Singh D, Dhakre JS. Some medicinal plants of Mathura district (UP). Mendel 1989; 6(1): 60-66.
28.Arya KR, Prakash V. Ethnomedicinal study of a remote tribal area of Almora district: A survey report- Part I. In: Ethnobotany and Medicinal plants of Indian Subcontinent. Scientific Publishers (India), Jodhpur, 2003, Pp: 247-52.
29.Zakavi F, Golpasand Hagh L, Daraeighadikolaei A, Farajzadeh Sheikh A, Daraeighadikolaei A, Leilavi Shooshtari Z. Antibacterial Effect of Juglans Regia Bark against Oral Pathologic Bacteria. Int J Dent 2013;2013:854765. doi: 10.1155/2013/854765.
30.Idu M. Umweni A, Odaro T, Ojelede L. Ethnobotanical plants used for oral healthcare among the Esan Tribe of Edo State, Nigeria. Ethnobotanical Leaflets. 2009;13:548-63.
31.Kumar N, Choyal R. Ethno-Medicinal uses of some plants of lower foot hills of Himachal Pradesh for the treatment of oral health problems and other mouth disorders. International Journal of Advanced Research. 2013;1(5):1-7.
32.Tomar A. Folk medicinal uses of some plants in Toothache. Ad Plant Sci. 2007;20:239-40.
33.Hebber SS, Harsha VH, Shripathi V, Hegde GR. Ethnomedicine of Dharwad district in Karnataka India – plants used in oral health care. J Ethnopharmacol. 2004;94(2-3):261-6.
34.Deepa KC, Mari J, Prabhu V. Ethnomedicinal practices for oral health and hygiene of tribal population of Wayanad, Kerala. International Journal of Research in Ayurveda and Pharmacy. 2011;2(4):1246-50.
35.Bhavin V. Oral health behavior among Bhils of Rajasthan. Journal of social science 2004;8(4):1-5.
36.Kelmanson JE, Jager AK, Staden J. Zulu medicinal plants with antibacterial activity. J Ethnopharmacol. 2000;69(3):241-6.
37.Saeki Y, Ito Y, Shibata M, Sato Y, Okuda K, Takazoe I. Antibacterial action of natural substances on oral bacteria. Bull Tokyo Dent Col. 1989;30(3):129-35.
38.Dzink JL, Socransky SS. Comparitive in vitro activity of sanguinariane against oral microbial isolates. Antimicrob Agents chemother. 1985;27(4):663-5.
39.Kumar G, Jalaluddin M, Rout P, Mohanty R, Dileep CL. Emerging trends of herbal care in dentistry. J Clin Diagn Res. 2013;7(8):1827-9. doi: 10.7860/JCDR/ 2013/6339.3282.
40.Vanka A, Tandon S, Rao SR, Udupa N, Ramkumar P. The effect of indigenous Neem Azadirachta indica mouth wash on Streptococcus mutans and lactobacilli growth. Indian J Dent Res. 2001;12:133–44.
41.Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous drugs of India. 2nd Edition, Calcutta: UN Dhur and Sons, 1958.
42.Yamamoto H, Ogawa T. Antimicrobial activity of perilla seed poyphenols against oral pathogenic bacteria. Biosci Biotechnol Biochem. 2002;66(4):921-4.
43.Ayub F, Thomas B, Paulaian B, Emil J. Herbs and dental caries-a review. Universal Journal of Pharmacy. 2013;2(5):18-21.
44.Pourabbas R, Delazar A, Chitsaz MT. The effect of German chamomile mouthwash on dental plaque and gingival inflammation. Iranian Journal of Pharmaceutical Research. 2005;2:105-9.
45.Pahlajani A, Pathak A, Thadani J. Commonly used plants in India to maintain oral hygiene- a review. Nat J Med Dent Res. 2013;1(2):22-5.
46.Swami Sadashiva Thirtha. The ayurveda in encyclopedia. Natural‘s secrets to healing, prevention, and longevity. 1st edition. Satguru publictions, 1998.
47.Mishra LC, Singh BB, Dagenais S. Ayurveda: a holistical perspective and principles of the traditional health care system of India. Altern Ther Health Med. 2001;7(2):36-42.
48.Nathan Occasio DD. Natural remedies recommended for the management of oral health. NYSDJ 1999.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2015. Lima Aapaliya P, Sinha S, Sinha L, Malik V. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Alyaa Hussein Hammadi1,*, Ali Abd-Alamer Jwad2, Ibrahim Adham Majeed3, Ehab Mudher Mikhael3
Affiliation:-
1Al-Diwaniya Teaching Hospital, Alqadisya, Iraq
2Lecturer of Otolaryngology, Department of General of Surgery, College of Medicine, University of AIqadisa, Al-Diwaniya, Iraq
3Clinical Pharmacy Department-College of Pharmacy- Baghdad University, Baghdad, Iraq
The name of the department(s) and institution(s) to which the work should be attributed:
Department of General of Surgery, College of Medicine, University of AIqadisa, Al-Diwaniya, Iraq
Author’s contributions:
Author 1 contributed towards concepts, design, literature survey, data acquisition, manuscript editing and preparation. Author 2& 3 contributed in Design, literature search and data acquisition.
Address reprint requests to
Alyaa H. Hammmdi.
Al-Diwaniya Teaching Hospital, Al-Diwaniya, Iraq
Article citation:
Hammmdi AH,Jwad AA,Majeed IA,Mikhae EM. The effectiveness, safety and cost of different intranasal steroid sprays in treating Iraqi patients with allergic rhinitis: A comparative study. J Pharm Biomed Sci.2015;05(01):61-66.Available at www.jpbms.info
ABSTRACT
Background: Allergic rhinitis is a common disease that associated with inflammation of the nasal airways resulting in symptoms of sneezing, nasal obstruction, and mucous discharge. Intranasal steroids are the first option for treatment of patients with mild – moderate AR. At which all available intranasal corticosteroids are safe and effective for this indication, differences in efficacy, side effects, and clinical attributes must be considered. So this study aimed to assess and compare the efficacy, safety and cost of different intranasal steroids (beclomethasone dipropinate, budesonide and mometasone furoate monohydrate) that available in Iraqi pharmacies for the treatment of allergic rhinitis patients.
Subjects & Methods: A randomized single blind clinical trial was done in Al-Diwaniya Teaching Hospital at ENT Unit at which sixty patients of both sexes with allergic rhinitis for at least 1 year were included in this study. The patients were divided into three groups with 20 patients in each group to receive either Beclomethasone dipropionate or mometasone furoate or Budesonide intranasal spray daily for 1 month. Clinical assessment of the allergic rhinitis is done by measuring symptom through the use of visual analog scales at beginning and at the end of the study. Blood samples of AR patients were collected at the beginning and at the end of the study to measure serum Immunoglublin E (IGE), Interleukin 5(IL5), Eocinophil cationic protein (ECP), Mast cell tryptase (MCT), T-Lymphocyte count.
Results: This study showed a non significant difference among intranasal steroids by their effect on lymphocyte count, IL5, MCT and ECP; however there was a significant difference in the effect of intranasal steroids on VAS, and IGE, at which VAS was significantly reduced by Beclomethasone; while IGE was significantly reduced by mometasone. Additionally there is a non significant difference in the topical side effects among all topical intranasal steroids. Furthermore there is a significantly higher monthly cost for the treatment of allergic rhinitis patients with mometasone nasal spray.
Conclusion: Beclomethasone dipropionate intranasal spray is an effective and cheap therapy when used for short periods for young adult allergic rhinitis patients without any risk from systemic side effects of steroids; while budesonide is a best alternative cheap therapy for Beclomethasone in allergic rhinitis with risk from systemic steroid side effects or who have compliance problems in using nasal steroids twice daily.
KEYWORDS: Allergic rhinitis; intranasal steroids; effectiveness, safety; cost.
REFERENCES
1.Passali D, Bellussi L, Damiani V, etal. Allergic rhinitis in Italy: epidemiology and definition of most commonly used diagnostic and therapeutic modalities. Acta Otorhinolaryngol Ital. 2003 Aug;23(4):257-64.
2.Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA). Allergy .2008; 63 (suppl 86):8–160.
3.Herman H. Once-daily administration of intranasal corticosteroids for allergic rhinitis: a comparative review of efficacy, safety, patient preference, and cost. Am J Rhinol. 2007;21:70–9.
4.Sur DK, Scandale S. Treatment of Allergic Rhinitis. Am Fam Physician. 2010 Jun 15; 81(12):1440-1446.
5.Wallace DV, Dykewics MS, Bernstein DI, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008;122(2 suppl):S1–S84.
6.Lee BJ, Kim YJ , Kim JH, Shin HS, Chung YS. A comparative study of intranasal budesonide and oral terfenadine in perennial allergic rhinitics: effect on the symptom score and nasal secretion eosinophils. J Asthma Allergy Clin Immunol. 2001; 21:216-22.
7.Stempel D. Improving the value of care for allergic rhinitis. Drug Benefit Trends. 1996; 8(1):11-2.
8.Mygind N, Lund V. Topical corticosteroid therapy of rhinitis. Clin Immunother .1996;5:122-36.
9.Lumry WR. A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis. J Allergy Clin Immunol. 1999;105:150-8.
10.Wallace DV, Dykewicz MS, Bernstein DI; Joint Task Force on Practice; American Academy of Allergy, Asthma & Immunology; American College of Allergy, Asthma & Immunology; Joint Council of Allergy, Asthma & Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008;122(2 suppl):S1-S84.
11.Erin EM, Leaker BR, Zacharasiewicz AS, etal. Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge. Allergy. 2005 Dec;60(12):1524-9.
12.Fokkens WJ, Rinia B, van Drunen CM, etal. No mucosal atrophy and reduced inflammatory cells: active-controlled trial with yearlong fluticasone furoatenasal spray. Am J Rhinol Allergy. 2012 Jan-Feb;26(1):36-44. doi: 10.2500/ajra.2012.26.3675.
13.Nielsen LP, Bjerke T, Christensen MB, Skamling M, etal. Eosinophil markers in seasonal allergic rhinitis. Intranasal fluticasone propionate inhibits local and systemic increases during the pollen season. Allergy. 1998 Aug ; 53(8):778-85.
14.Di Lorenzo G, Pacor ML, Pellitteri ME, Morici G, etal. Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in monotherapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis. Clin Exp Allergy. 2004 Feb;34(2):259-67.
15.G. K. Scadding, S. R. Durham, R. Mirakian, etal. BSACI guidelines for the management of allergic and non-allergic rhinitis. Clin Exp Allergy. 2008 Jan;38(1):19-42.
16.Bryan Wong. A REVIEW OF INTRANASAL CORTICOSTEROIDS IN THE TREATMENT OF ALLERGIC RHINITIS. Pharmanote 2013; 28(10).
17.Corren J. Intranasal corticosteroids for allergic rhinitis: how do different agents compare? J Allergy Clin Immunol. 1999;2 :S144–S149. doi: 10.1016/S0091-6749(99)70310-6.
18.Peter Small, and Harold Kim. Allergic rhinitis: review. Allergy, Asthma & Clinical Immunology. 2011, 7(Suppl 1):S3.
19.J Sastre, R Mosges. Local and Systemic Safety of Intranasal Corticosteroids. J Investig Allergol Clin Immunol. 2012; 22(1): 1-12.
20.Lynn Lambert. Intranasal corticosteroids.S Afr Pharm J 2013; 80(6):22-24.
21.Waddell AN , Patel SK, Toma AG, Maw AR. Intranasal steroid sprays in the treatment of rhinitis: is one better than another? J Laryngol Otol. 2003;117(11):843-5.
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