DocumentsDate added
Original article
Mangal S Pawar*, YS Tawar
Affiliation:-
Department of Pharmaceutics, Bhupal Nobles, College of Pharmacy, Udaipur, Rajasthan, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Pharmaceutics, Bhupal Nobles, College of Pharmacy, Udaipur, Rajasthan, India
Address reprint requests to
Mangal S Pawar.
Department of Pharmaceutics, Bhupal Nobles, College of Pharmacy, Udaipur, Rajasthan,India
Article citation:
Panwar MS,Tanwar YS. Evaluation of stability of diltiazem hydrochloride floating microspheres at normal and accelerated conditions. J Pharm Biomed Sci.2015;05(01):57-60.Available at www.jpbms.info
ABSTRACT
The floating microspheres formulation containing diltiazem hydrochloride was prepared by non aqueous solvent evaporation method. With the recent trend towards globalization of manufacturing operation, it is imperative that the final product be sufficiently rugged for marketing worldwide under various climatic conditions including tropical, sub tropical and temperate. Stability studies were carried out as per ICH guidelines. The floating microspheres were placed in a screw capped glass containers and stored at room temperature, (25 ± 2°C) and humidity chamber (40°C, 75 % RH) for a period of 90 days. The product was evaluated for appearance every 10 days. Drug polymer compatibility and drug release studies were conducted as per the planned scheduled.
KEYWORDS: Diltiazem hydrochloride, Floating microspheres, Stability studies.
REFERENCES
1.ICH-International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use, Stability testing: photostability testing of new drug sub-stances and products, Q1B, 1996.
2.World Health Organization, Annex 2: Stability Testing of Active Pharmaceutical Ingredients and Finished Pharmaceutical Prod-ucts, vol. 953 of WHO Technical Report Series, 2009.
3.Indian Pharmacopoeia, Delhi. Government of India, Ministry of Health & Family welfare, published by controller of publications, 1996; 2:797.
4.Jain NK et al. Controlled and Novel Drug Delivery. 1st ed. New Delhi: CBS Publishers and Distributors; 1997.
5.Robinson JR, Lee VHL, Controlled Drug Delivery: Fundamentals andApplications. 2nd ed. New York: Marcel Dekker; 1978.
6.Yeole PG, Khan Shagufta, Patel VF, Floating drug delivery systems: Need and development. Indian J. Pharm. Sci. 2005;67(3):265-72.
7.Ryden T, Jonsson UE. A study of the absorption of diltiazem from the distal parts of the gastrointestinal tract. Eur J Clin Pharmacol, 1989; 36 (suppl):A243.
8.Menon A, Ritschel WA, Sarkar A, development and evaluation of a monolithic floating dosage form for furosemide. J. Pharm Sci. 1994; 83:239-45.
9.Costa P and Lobo JMS, “Modeling and comparison of dis-solution profiles,” European Journal of Pharmaceutical Sciences, vol. 13, pp. 123–133, 2001.
10.Bajaj S., Singhla Dinesh, Sakhuja Neha, “Stability testing of pharmaceutical products”, Journal of applied pharmaceutical science ,Vol.2 (3):129-138.
11.Zhenqiu Yang, Baozhen Song, Qiaoxia Li, Honglei Fan, Fan Ouyang. Preparation of Microspheres with microballoons inside for floating drug delivery systems. J Appl Polymer Sci 2004;94:197-202
12.Martin AN, Swarbrick J, Commarata A. Physical pharmacy. 3 rd ed. Philadelphia: Lea and Febiger; 1983. p. 423-5.
13.Kiyoyama S, Shiomori K, Kawano Y, Hatate Y. Preparation of microcapsules and control of their morphology. J Microencapsul 2003;20:497-508.
14.Streubel A, Siepmann J, Bodmeier R. Floating microparticles based on low density foam powder. Int J Pharma 2002;241:279-82.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2015. Panwar MS, Tanwar YS. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Sougata Kumar Burman1,*,Debasis Das2,Subrata Das3,Ronita Roy Chowdhury4,Jayita Mukherjee4,Jayanta Nandi5
Affiliation:-
1Assistant Professor, 4Clinical Tutor, Obstetrics & Gynaecology, College of Medicine & J N M Hospital, WBUHS, Kalyani, Nadia,India
2Associate Professor, Community Medicine, Malda Medical College, Malda,India
3R M O cum Clinical Tutor, Obstetrics & Gynaecology, Burdwan Medical College, Burdwan,India
5R M O cum Clinical Tutor, Obstetrics & Gynaecology, North Bengal Medical College,Sushrut Nagar, Darjeeling,WB,India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Obstetrics & Gynaecology, College of Medicine & J N M Hospital, WBUHS, Kalyani, Nadia, India
2.Malda Medical College, Malda,India
3.Obstetrics & Gynaecology, Burdwan Medical College, Burdwan,India
4.Obstetrics & Gynaecology, North Bengal Medical College, Sushrut Nagar, Darjeeling, WB, India
Address reprint requests to
Dr.Sougata Kumar Burman
Assistant Professor, Obstetrics & Gynaecology, College of Medicine & J N M Hospital, WBUHS, Kalyani, Nadia,India
Article citation:
Burman SK,Das D,Das S,Chowdhury RR,Mukherjee J,Nandi J. Efficacy of misoprostol and dilatation & evacuation in early pregnancy, abortion: A prospective Randomized Control Trial in a Tertiary care Institution of Kolkata, West Bengal.J Pharm Biomed Sci. 2015; 05(01):19-24. Available at www.jpbms.info
ABSTRACT: Objectives: Assessing the efficacy of misoprostol(800 µg p/v) with surgical evacuation in the treatment of early pregnancy failure (<12 week period of gestation), adverse effects of misoprostol compared to surgical evacuation for early pregnancy failure and comparing the treatment outcome (bleeding pattern). Methodology: It is a prospective Randomized Controlled Trail conducted in the department of obstetrics and gynaecology at the Nilratan Sircar Medical College & Hospital,Kolkata 700014 during April 2011 to March 2012. Applying inclusion & exclusion criteria, consecutive 100 patients carrying pregnancy of 12 weeks or less with early pregnancy failure were selected for the study. Selected patients were randomly assigned either in Misoprostol or surgical evacuation, group keeping equal no. of cases in both the group. Participants assigned to medical treatment received 800µg of Misoprostol inserted into the posterior vaginal fornix on the day of enrollment, i.e., Day 1st . If expulsion was not complete by Day 3rd ,they will receive a second dose of Misoprostol (800µg). If by the Day 8 expulsion were not complete then surgical evacuation or dilatation and evacuation was done.Participants assigned to dilatation and evacuation, group would undergo the procedure in operation theatre.Primary outcome measured was completeness of evacuation without the need for additional surgery, confirmed with ultrasonography. Secondary outcome variables were bleeding pattern following treatment,patients requiring blood transfusion,acceptability of misoprostol versus dilatation and evacuation. Hb% on Day 1st & 5th , Safety evaluation in terms of maternal subjective complaints like, lower abdominal pain, fever, diarrhoea were also judged.Result:In Misoprostol group induction-abortion interval (between first dose of the drug to evacuation) was 6-8 hours among 20(40%) cases, 9-10 hours in 12(24%) cases and more than 11 hours in 10(20%) cases.23 patients receiving misoprostol experienced side effects with no incidence of rupture uterus. 10(20%) cases found nausea, 3(6%) – vomiting and 10(20%) found with fever(1000F). In Misoprostol group mean Haemoglobin level on Day 1 & Day 15 were 11.7±0.82 & 10.3±0.51gm% respectively and the difference was found statistically significant. In D& E group, Hb% were11.8±.66&10.6±.51gm% respectively.
Conclusion: Medical management represents an efficacious and safe alternative for women preferring non-surgical treatment of EPF.
KEYWORDS: Misoprostol; Dilatation & Evacuation; Early pregnancy abortion; Comparison; Kolkata.
REFERENCES
1.Semin Reprod Med .Medical management of early pregnancy failure.2008;9(5):401-410.
2.Kuldip Singh,Y F Fong,F Dong.A viable alternative to surgical vacuum aspiration:repeated doses of Intravaginal misoprostol over 9 hours for medical treatment of pregnancies upto 8 weeks.BJOG:February 2003;10:175-80.
3.Thomas Betsy, HabeebullahS.Vaginalmisorostol for medical evacuation of early pregnancy failure.JGOG India,2004;54(4):340-2.
4.David Stockhein et al.Misoprostol for early pregnancy failure.IMAJ2010;12:375-6.
5.Davis AR, HendlishSK,Westhoff C et al. Bleeding patterns after misoprostol vs. surgical treatment of early pregnancy failure, results from an RCT.Am J ObstetGynecol 2007;196:31.e 1-31.e7.
6.R Chawdhary, Arana,N Pradhan.Mifepristone plus vaginal misoprostol vs. vaginal misoprostol alone for medical abortion in gestation 63 days or less in Nepalese Women.A quasi randomized trial.JOGR, 2009;35(1):78-85.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014. Burman SK,Das D,Das S,Chowdhury RR,Mukherjee J,Nandi J. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Monika Srivastava1,*, Vandana Sharma2, Asha Dixit3, Abhijeet Yadav4,Deepak Sharma5, Dhiraj Kumar Srivastava6
Affiliation:-
1-5Department of Anatomy, Gandhi Medical College, Bhopal (MP), India
6Department of Community Medicine, UP Rural Institute of Medical Sciences & Research, Saifai, U.P, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Anatomy, Gandhi Medical College, Bhopal (MP),India
2.Department of Community Medicine, UP Rural Institute of Medical Sciences & Research, Saifai, U.P, India
Address reprint requests to
Dr. Monika Srivastava.
C/o Mr. R.K Srivastava
H.no 1532, Near Ebnezer School, Bhagat Singh Nagar, Bhind Road, Gola Ka Mandir, Gwalior (MP)-474005
Article citation:
Srivastava M, Sharma V, Dixit A, Yadav A, Sharma D, Srivastava DK. Morphological analysis of myocardial bridges in formalin fixed hearts. J Pharm Biomed Sci.2015;05(01):01-05.Available at www.jpbms.info
ABSTRACT
Background: The fibers overlying the intramyocardial segment of an epicardial coronary artery are then termed as myocardial bridges. Although myocardial bridges may protect the covered arterial segment, in man there is a significant increase in the incidence of atherosclerosis in the vessel segment proximal to the myocardial bridges
Objectives: 1.Incidence of myocardial bridges. 2. Morphological distribution of myocardial bridges over the various branches of coronary arteries.
Material and Method: The present study was a Dissection (Hospital) based Cross sectional Descriptive study.. A total 60 hearts were dissected. The hearts were cleaned and numbered. They were dissected and Coronary Vessels were then traced from the aortic sinus to their termination by cleaning the epicardium and perivascular fat tissues by using different type’s forceps and scalpel. The origins and courses of two coronary arteries were thus cleared, colored and all the measurements were taken with the help of thread and ruler. Result: Out of total 60 hearts, 22 hearts showed the presence of myocardial bridges (36.7%). A higher incidence of myocardial bridges was noted in the left coronary artery as compared to right coronary artery. In the left coronary artery maximum incidence was noted in the anterior interventricluar artery followed the posterior interventricular branch.
Conclusion:The present study concludes that myocardial bridges are common in human hearts. They are more common in the left coronary artery and its branches. An anterior Interventricular branch of left coronary artery is most commonly affected.
KEYWORDS: Myocardial Bridges; Coronary arteries; Left Coronary artery.
REFERENCES
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2015. Srivastava M, Sharma V, Dixit A, Yadav A, Sharma D, Srivastava DK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Review article
Pankaj Aapaliya1,*, Surina Sinha,2 Lavina Sinha3, Vikas Malik4
Affiliation:-
1MDS, Post Graduate student, Department of Public Health Dentistry, Pacific Dental College and Hospital, Airport Road, Debari, Udaipur, Rajasthan, India
2MDS, Post Graduate student, Department of Orthodontics & Dentofacial Orthopaedics, Pacific Dental College and Hospital, Airport Road, Debari, Udaipur, Rajasthan, India
3MD, Post Graduate student, Department of Medicine, C U Shah Medical College, Surendranagar, Gujarat, India
4MDS, Associate Professor, Department of Orthodontics & Dentofacial Orthopaedics, SGT Dental College, Budhera, Gurgeon, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Public Health Dentistry, Pacific Dental College and Hospital, Airport Road, Debari, Udaipur, Rajasthan, India
2.Department of Medicine, C U Shah Medical College, Surendranagar, Gujarat, India
3.Department of Orthodontics & Dentofacial Orthopaedics, SGT Dental College, Budhera, Gurgeon, India
Address reprint requests to
Dr. Pankaj Aapaliya.
MDS, Post Graduate student,
Department of Public Health Dentistry,
Pacific Dental College and Hospital, Airport Road, Debari, Udaipur–313024,Rajasthan,India
Phone Number: +919428746380; Fax: +912942491508
Article citation:
Aapaliya P,Sinha S,Sinha L,Malik V. Ethno-dentistry: Tapping the potential of indigenous plants for therapeutic dentistry. J Pharm Biomed Sci. 2015; 05(01):31-38. Available at www.jpbms.info
ABSTRACT:
Oral diseases, including dental caries and periodontal diseases are major health problems worldwide. Oral health is integrated to the general quality of life that extends beyond the functions of the craniofacial complex. Traditional medicine can treat various infections and chronic conditions. Problems such as deformities of the oral cavity and oral infections were cured in ancient India. Ayurvedic medication been used for various ailments since immemorial time. Scientific validations of the Ayurveda in dental health practices could justify their incorporation into modern dental care. The ethnomedical system rooted in rich biodiversity associated knowledge, particularly in Asia is well known. Publicity of these systems would benefit the general population by imparting more confidence in the ancient practices. This review shows plants products are currently gaining attention for treatment of various ailments in dentistry.
KEYWORDS: Ethnomedicine; herbs; Plants; Oral disease.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2015. Lima Aapaliya P, Sinha S, Sinha L, Malik V. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Cláudio Gleidiston Lima da Silva, Raul Rodrigues Barros, Bernardo Nogueira Faé, Jucier Gonçalves Júnior, João Vitor Cândido Pimentel, Modesto Leite Rolim Neto, Maria do Socorro Vieira dos Santos*
Affiliation:-
Faculty of Medicine,Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil.
The name of the department(s) and institution(s) to which the work should be attributed:
Faculty of Medicine,Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil.
Address reprint requests to
Maria do Socorro Vieira dos Santos.
284, Divine Savior Street, Downtown, Barbalha, Ceará, Brazil, 63180000.
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ABSTRACT:
Background: Strongyloidiasis is a parasitic infection caused most commonly by Strongyloides stercoralis, an endemic helminth in rural populations of tropical and subtropical climates. There are many clinical presentations, but most infected patient presents asymptomatically or with classic symptoms of helminthiasis; however, atypical presentations are occasionally seen. Case report: We report a case of strongyloidiasis simulating a gastric tumor, in a dyspeptic patient with risk factors for stomach cancer. Diagnosis was achieved through histopathology examination of the lesions, which showed larvae of S. stercoralis. This case was treated by Albendazole. Conclusions: After all, we concluded that gastrointestinal cancers must have strongyloidiasis as a differential diagnosis. And our case is important for (re-)estimating the burden of helminth infections and highlights the need for integrating epidemiological surveys, rigorous diagnostic approaches and clinical assessments in the developing world.
KEYWORDS: Atypical presentation; Case report; Strongyloidiasis.
Article citation:
Lima da Silva CG, Rodrigues RB, Faé BN, Gonçalve J, Pimentel Cândido JV, Rolim-Neto ML, et al. Strongyloidis stercoralis simulating gastric tumor: A case report. J Pharm Biomed Sci. 2014;05(01):06-09. Available at www.jpbms.info
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014. Lima da Silva CG,Rodrigues RB,Faé BN,Gonçalve J,Pimentel Cândido JV,Rolim-Neto ML, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.