DocumentsDate added
Original article
Kirti Jaiswal1,*, Sandip Kumar2, Santosh Kumar Sant3, Amit Kant Singh4,
ANG Hyder5, Abid Ahsan6
Affiliation:
1Associate Professor, Department of Physiology, UP RIMS & R, Saifai, Etawah, U.P, India
2AssociateProfessor, Department of Community Medicine, UP RIMS & R, Saifai, Etawah, India
3Associate Professor, Department of Physiology, UP RIMS & R, Saifai, Etawah, U.P, India
4Associate Professor, Department of Physiology, UP RIMS & R, Saifai, Etawah, U.P, India
5Lecturer, Department of Physiology, UP RIMS & R, Saifai, Etawah, U.P, India
6Assistant Professor, Department of Physiology, Hind Institute of Medical Sciences, Barabanki UP, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Physiology, UP RIMS & R, Saifai, Etawah, U.P, India
Department of Community Medicine, UP RIMS & R, Saifai, Etawah, India
Hind Institute of Medical Sciences, Barabanki UP, India
Authors contribution:
Author 1 &3 design the study, 5 & 6 collected the data and 2 & 4 analyse the data.
Address reprint requests to
Dr. Kirti Jaiswal
Associate Professor,
Department of Physiology,
UP Rural Institute of Medical Sciences & Research,
Saifai, Etawah, 206 130 (U.P.), India or at drkirtijaiswal@yahoo.com
Article citation: Jaiswal K,Kumar S,Sant KS,Singh AK,Hyder ANG,Ahsan A. A Study on Pulmonary Function Tests in Bangle workers of a district of central Uttar Pradesh, India J Pharm Biomed Sci.2015;05(02):90-94.Available at www.jpbms.info
ABSTRACT:
The pulmonary function impairment is a common respiratory problem among industrial exposure. Therefore, the present study was undertaken to evaluate the effects of furnace smoke and flue and its duration of exposure on lung function. This is a matched cross-sectional study of Spirometry in 100 bangle workers with age range 20 – 60 years, who worked without smoke control ventilation or respiratory protective devices. Pulmonary function tests were performed by using Digital Spirometer (Spiro-excel). Significant, reduction was observed in the mean values of Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), Forced Expiratory Ratio (FEV1/FVC%), Forced Expiratory Flow (25% -75%) and Peak Expiratory Flow Rate (PEFR) in bangle workers relative to their matched controls. It is concluded that lung functions in bangle workers is impaired.
KEYWORDS: Occupational hazards; pulmonary function; bangle workers.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Jaiswal K, Kumar S, Sant KS, Singh AK, Hyder ANG, Ahsan A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Bouchra Rahmouni1,*, Katim Alaoui2, El Houcine Bouidida1,2,3, Malika chammache4, Mohammed Sghir Taleb5, Yahia Cherrah2, Abdelkader Il Idrissi1
Affiliation:
1Department of Chemistry, Laboratory of Plants Chemistry, Organic and Bio- Organic Synthesis, Faculty of Sciences, University MohammedV, Agdal, Rabat, BP 1014, Morocco
2Pharmacology and Toxicology Laboratory, Faculty of Medicine and Pharmacy, Rabat, Morocco
3National Drug Control Laboratory, Direction of Drug and Pharmacy, Ministry of Health, BP 6203, Rabat-Institutes, Rabat, Morocco
4Department of Chemistry, heterocyclic chemistry Laboratory, Faculty of Sciences, University MohammedV, Agdal, Rabat, Morocco, Rabat, BP 1014, Morocco
Department of Botany and Plant Ecology, Scientific Institute, University Mohammed V, Rabat, Morocco
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Chemistry, Laboratory of Plants chemistry, Organic and Bio- Organic Synthesis, Faculty of Sciences, University MohammedV, Agdal, Rabat, BP 1014, Morocco
Address reprint requests to
* Bouchra Rahmouni
Department of Chemistry, Laboratory of Plants chemistry, Organic and Bio- Organic Synthesis, Faculty of Sciences,University MohammedV, Agdal, Rabat, BP 1014, Morocco
Tel : (+212) 6 63238191
Fax:(+212) 5 37 68 19 31
Article citation:
Rahmouni B,Alaoui K,Bouidida El-H,Chammache M,Taleb MS,Cherrah Y,Idrissi A. Acute toxicity, analgesic activity of Nepetagranatensis essential oil. J Pharm Biomed Sci. 2015; 05(02):110-117. Available at www.jpbms.info
ABSTRACT:
To evaluate the acute toxicity and the peripheral and central analgesic activity of the genus Nepeta, we studied the essential oil of Nepetagranatensis Boiss spontaneous species of Morocco. We have obtained the essential oil of N. granatensis by microwave irradiation and identified by GC-MS.
Female mice IOPS ofa,20-30g,were used to study the acute toxicity, as well as for the peripheral analgesic activity (Koster test). However, the study of the central analgesic activity (tail flick test) was conducted on rats Waster 250-350g. Doses of 25mg/kg and 50mg/kg of EO were administered intraperitoneally for both peripheral and central analgesic activities.The identification of the EO led to 25 constituent whose nepetalactone is the major product.The essential oil revealed a LD50 of 1000mg/kg. Koster test has shown a major protective power against abdominal cramps 74, 11 % at 25mg/kg and reached 86.77 % at 50mg/kg. However, the reflex time in the tail flick test exceeded the threshold of pain inhibition, which reached 8.46 s for the 50mg/kg dose.
EO had proved a low acute toxicity, and a great potential analgesic activity type ASA and morphine- like at 50mg/kg, which is probably due to its richness in nepetalactone
KEYWORDS: Acute toxicity; Analgesic activity; Essential oil; Microwave; Nepetagranatensis; nepetalactone.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Rahmouni B, Alaoui K, Bouidida El-H, Chammache M, Taleb MS, Cherrah Y, IL Idrissi A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mini review
Shubham Singh, Supraj Raja Sangam, Venkateswara Rao Joginapalli, Senthilkumar Rajagopal*
Affiliation:
Department of Zoology, Nizam College, Hyderabad, Telangana, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Zoology, Nizam College, Hyderabad, Telangana, India
Address reprint requests to
*Dr. Senthilkumar Rajagopal.
Department of Zoology, Nizam College, Hyderabad, Telangana, INDIA
Article citation: Singh S, Sangam SR, Joginapalli VR, Rajagopal S. Alcohol-induced gastric inflammation. J Pharm Biomed Sci. 2015; 05(02):174-177. Available at www.jpbms.info
ABSTRACT:
Accumulating evident suggests that gastrointestinal systems (GI) is more vulnerable to the oxidative stress, exposure to Reactive oxygen species (ROS) and is a prospective diseases like fatty liver, cirrhosis, diarrhea, vomiting, and inflammatory bowel diseases (IBD). GI tract plays a particularly important role in the alcohol metabolism and absorption among the many other organ systems in the body. Alcohol/acetaldehyde is an oxidative stress inducer on gastric epithelial cells. Alcohol-induced damage to the mucosal lining of the stomach also increases the risk of gastric inflammation and gastric cancer. Moreover, increasing evidences suggests that investigating the important genes involving the gastric cancer are very intrigue. This article communicates the molecular aspects of gastritis and gastric cancer.
KEYWORDS: Alcohol, glycine; gut microbiota; inflammatory bowl diseases; reactive oxygen species.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: Department of Biotechnology, Ministry of Science & Technology, and Government of India to R.S
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Singh S, Sangam SR, Joginapalli VR, Rajagopal S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Simarpreet V.Sandhu1., MDS, MAMS., Rajeev Tiwari2 ., MD., Preetinder Kaur3,*.,BDS., RamanPreet K Bhullar4., MDS., Rajat Bhandari5., MDS., Shivani Garg6.,BDS.
Affiliation:
1Professor and Head, Department of Oral & Maxillofacial Pathology, Genesis Institute of Dental Sciences & Research, Ferozepur-Moga Road, Ferozepur-152001, Punjab, India
2Professor and Head, Department of Microbiology, Genesis Institute of Dental Sciences & Research, Ferozepur-Moga Road, Ferozepur,152001, Punjab, India
3PG Student, Department of Oral & Maxillofacial Pathology, Genesis Institute of Dental Sciences & Research, Ferozepur-Moga Road, Ferozepur-152001, Punjab, India
4,5Reader, Department of Oral & Maxillofacial Pathology, Genesis Institute of Dental Sciences & Research, Ferozepur-Moga Road, Ferozepur-152001, Punjab, India
6PG Student, Department of Oral & Maxillofacial Pathology, Genesis Institute of Dental Sciences & Research, Ferozepur-Moga Road, Ferozepur-152001, Punjab, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Oral & Maxillofacial Pathology, Genesis Institute of Dental Sciences & Research, Ferozepur-Moga Road, Ferozepur-152001, Punjab, India
Address reprint requests to
* Preetinder Kaur.
Department of Oral & Maxillofacial Pathology, Genesis Institute of Dental Sciences & Research, Ferozepur-Moga Road, Ferozepur152001, Punjab, India
Article citation:
Sandhu SV, Tiwari R, Kaur P, Bhullar RamanPreet K, Bhandari R, Garg S. Antifungal activity of commonly used spices in indian households against oral candidiasis: An In vitro study. J Pharm Biomed Sci. 2015;05(02):160-165.Available at www.jpbms.info
ABSTRACT:
Background: The frequency of life-threatening infections caused by pathogenic microorganisms has increased worldwide. Due to the increasing development of drug resistance in human pathogens as well as the appearance of undesirable effect of certain antimicrobial agents, there is a need to search for new agents without toxicity and side effects. Research on antimicrobial effects of plants assumes certain importance because of fewer side effects and being economically cost effective.
Aim: To evaluate the anticandidal effects of alcoholic and aqueous extracts of Cinnamomum zeylanicum (cinnamon), Eugenia aromatica (clove) and Curcuma longa (turmeric).
Material & methods: Candida obtained from the palate of a denture wearing patient was inoculated on the Sabouraud Dextrose Agar (SDA) medium. Streaking was done on petri dishes containing SDA medium with respective plant extracts and which were incubated at 37°C for 48 hours. The anticandidal activity of the extracts and their potency was qualitatively assessed by the presence or absence of growth on the culture plates.
Results: The results showed that both alcoholic and aqueous plant extracts of clove and alcoholic extract of cinnamon exhibited inhibitory effect on candidal growth.
Conclusion: Plant extracts could be used as a good alternative to overcome the unavoidable side effects of available antifungals.
KEYWORDS: Antimicrobial; Candida; plant extracts; Sabouraud Dextrose Agar (SDA).
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Sandhu Sv,Tiwari R,Kaur P,Bhullar RamanPreet K,Bhandari R,Garg S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
P.Vijayalakshmi* M.D (Microbiology)
Affiliation:
Department of Microbiology, Malla Reddy Medical College for Women, Suraram, Hyderabad, Telangana, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, Malla Reddy Medical College for Women, Suraram, Hyderabad, Telangana, India
Address reprint requests to
*Dr.P.Vijayalakshmi.
Professor & H.O.D
Department of Microbiology
Malla Reddy Medical College for Women
Suraram, Hyderabad, Telangana, India
Article citation: Vijayalakshmi P. Association of STD with HIV. J Pharm Biomed Sci. 2015; 05(02):166-167. Available at www.jpbms.info
ABSTRACT: Background: STDs such as genital ulcer disease and possibly chlamydia trachomatis genital infections, facilitate the sexual transmission of HIV infection, thus making STD clinic attenders potentially more susceptible to HIV transmission.
Objective:To determine the prevalence of HIV in STD patients.
Methods: Data was collected from 200 patients suffering from STDs for a period of one year.
Blood samples were collected from 100 normal, healthy, voluntary blood donors to serve as a control for the present study. The diagnosis of the various STDs was established by standard laboratory investigations done with blood, urine, cervical, vaginal and urethral swabs and exudates from the lesions.
The VDRL test was routinely performed on all the sera collected.
ELISA test was employed for HIV screening. The ELISA test was repeated in positive cases and confirmation was done by the Western Blot test, at the National Institute of Virology, Pune.
Results: Of the 20 reactive cases, 17 were found to be suffering from genital ulcerative disease, predominantly syphilis and chancroid .
Conclusion: HIV infection was found to be more in younger age groups, more in males than in females.
KEYWORDS: HIV; STD; Prevalence.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Vijayalakshmi P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.