DocumentsDate added
Original article
Vinit Kumar1, Sonam Birtharey1, Neha Gupta1, Krishna K Yadav1,*,Sanjay K Vishwakarma2
Affiliation:
1Institute of Environment and Development Studies, Bundelkhand University, Jhansi, U.P., India
2Department of Biotechnology, Microtek Institute of Technology and Management, Varanasi, U.P., India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Institute of Environment and Development Studies, Bundelkhand University, Jhansi, U.P., India
2.Department of Biotechnology, Microtek Institute of Technology and Management, Varanasi, U.P., India
Address reprint requests to
*Krishna Kumar Yadav.
Institute of Environment and Development Studies, Bundelkhand University, Jhansi, U.P., India
Article citation:
Kumar V, Birtharey S, Gupta N, Yadav KK, Vishwakarma SK. Study of Biomedical waste generation and management by government and private hospitals in Jhansi City(U.P.), India. J Pharm Biomed Sci. 2015; 05(02):122-125. Available at www.jpbms.info
ABSTRACT:
All over the country, unsegregated and untreated biomedical waste is being indiscriminately discarded into municipal bins, dump site, road side and in water bodies or is being incompletely and improperly burnt in open. All this is leading to rapid proliferation and spreading many infectious, dangerous and fatal communicable diseases like hepatitis, AIDS and several types of cancers. In urban and rural areas alike, incidence and prevalence of several such human diseases has increased and the per capita medical expenditure has also gone high several folds. In present study, biomedical waste was collected from different government and private hospitals of Jhansi city. After collection, different method of safe disposal of these wastes are tried and found suitable for biomedical waste management.
KEYWORDS: Biomedical waste; Government; Health Care, Hospital;Jhansi, Management; Private.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2015. Kumar V, Birtharey S, Gupta N, Yadav KK, Vishwakarma SK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Guo Chen1, Zhenghua Ni2, Qingge Chen1, Xiongbiao Wang1,*
Affiliation:
1Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, PR China
2Central lab, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, PR China
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine &
2. Central lab, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China
Address reprint requests to
Xiongbiao Wang.
Central lab, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062,PR China
Article citation:
Wang et al. Gene silencing of IL-13 by siRNA aerosol inhalation inhibits asthma phenotype in the murine model of asthma. J Pharm Biomed Sci. 2015; 05(02):126-130. Available at www.jpbms.info
ABSTRACT:
Background: interleukin-13 has been shown to be a critical mediator of the asthma phenotype. It was reported that intravenously administration of the IL-13 siRNA in vivo reduced airway resistance significantly in the murine asthma model.
Objectives: This study was intended to investigate whether aerosol inhalation of IL-13 siRNA was effective in reduce IL-13 expression and thus attenuated asthma phenotype.
Methods: The ovalbumin (OVA)-challenged mouse model of asthma was used to assess the effect of IL-13 interference. Airway inflammation in lung tissue was assessed using hematoxylin and eosin (H&E). The mRNA expression of IL-13 gene was determined using real-time PCR.
Results: Aerosol inhalation of the IL-13 siRNA was shown to reduce the expression of IL-13 and reduced airway inflammation in lung tissues compared with control group.
Conclusion: Our results demonstrated the effectiveness of aerosol inhalation of IL-13 siRNA in preventing airway inflammation in vivo and suggested potential therapeutic applications.
KEYWORDS: IL-13; siRNA; asthma; aerosol inhalation.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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13.Huang HY, Lee CC, Chiang BL (2008) Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness. Gene Ther 15: 660-667.
14.Darcan-Nicolaisen Y, Meinicke H, Fels G, Hegend O, Haberland A, et al. (2009) Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice. J Immunol 182: 7501-7508.
Source of funding: This work was supported by the Shanghai Science and Technology Committee (No.10411969100, No.12401900404).
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Veeranjaneyulu.P1,*.,MS(ENT),DLO, Ajay K Yadlapalli1,¥.,MS(ENT), Santosh K Batchu1,¥.,MS(ENT), Amjad Khan1,£.,MBBS, Rachana Chollangi1,£.,MBBS
Affiliation:
1Professor &Head,1,¥ Assistant Professor,1,£Junior resident, Department of ENT, GSL medical college, Rajahmundry, Andhra Pradesh, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of ENT, GSL medical college, Rajahmundry, Andhra Pradesh, India
Address reprint requests to
Dr. Veeranjaneyulu .P,
Professor and Head, Dept of ENT, GSL medical college, Rajanagaram, Rajahmundry, Andhrapradesh–533 296, India
Article citation:
Veeranjaneyulu P,Yadlapalli AK, Batchu SK, Khan A, Chollangi R. Recurrent nasopharyngeal angiofibroma: Endoscopic excision. J Pharm Biomed Sci. 2015; 05(02):104-109. Available at www.jpbms.info
ABSTRACT:
Juvenile Nasopharyngeal Angiofibroma (JNA) is a benign vascular neoplasm, the etiologic origin of which remains elusive. It comprises less than 0.5 % of all head and neck tumours. It occurs exclusively in males usually in the adolescent age.
Surgical excision, preferably with a preoperative embolisation,is the complete treatment of choice though recurrences are a rare possibility. Recurrence rate ranges from 6% to 27.5 %.
Endoscopic excision is done in some tumours of limited extension because of the benign nature of the neoplasm and its location in a cosmetically sensitive zone.
Here, we present a case of recurrent nasopharyngeal angiofibroma in a male patient of 16 yrs for whom endoscopic excision was done and there was no further recurrence, followed by the discussion on the etiologies, clinical features and the treatment modalities of nasopharyngeal angiofibroma.
KEYWORDS: Angiofibroma; Benign; Gammaknife surgery; Juvenile nasopharyngeal angiofibroma; Endoscopic excision; Nasopharynx; Recurrence; Vascular neoplasm; lasers; coblation; radiation therapy.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
REFERENCES
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4.Madhavan Nirmal R, Veeravarmal V, Santha Devy A, Ramachandran CR., Unusual presentation of nasopharyngeal (juvenile) angiofibroma in a 45 year old female, Indian J Dent Res. 2004 Oct-Dec;15(4):145-8.
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8.Paris J1, Guelfucci B, Moulin G, Zanaret M, Triglia JM, Diagnosis and treatment of juvenile nasopharyngeal angiofibroma., Eur Arch Otorhinolaryngol. 2001 Mar;258(3):120-4.
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Source of funding: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Veeranjaneyulu P,Yadlapalli AK, Batchu SK, Khan A, Chollangi R.. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Bouchra Rahmouni1,*, Katim Alaoui2, El Houcine Bouidida1,2,3, Malika chammache4, Mohammed Sghir Taleb5, Yahia Cherrah2, Abdelkader Il Idrissi1
Affiliation:
1Department of Chemistry, Laboratory of Plants Chemistry, Organic and Bio- Organic Synthesis, Faculty of Sciences, University MohammedV, Agdal, Rabat, BP 1014, Morocco
2Pharmacology and Toxicology Laboratory, Faculty of Medicine and Pharmacy, Rabat, Morocco
3National Drug Control Laboratory, Direction of Drug and Pharmacy, Ministry of Health, BP 6203, Rabat-Institutes, Rabat, Morocco
4Department of Chemistry, heterocyclic chemistry Laboratory, Faculty of Sciences, University MohammedV, Agdal, Rabat, Morocco, Rabat, BP 1014, Morocco
Department of Botany and Plant Ecology, Scientific Institute, University Mohammed V, Rabat, Morocco
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Chemistry, Laboratory of Plants chemistry, Organic and Bio- Organic Synthesis, Faculty of Sciences, University MohammedV, Agdal, Rabat, BP 1014, Morocco
Address reprint requests to
* Bouchra Rahmouni
Department of Chemistry, Laboratory of Plants chemistry, Organic and Bio- Organic Synthesis, Faculty of Sciences,University MohammedV, Agdal, Rabat, BP 1014, Morocco
Tel : (+212) 6 63238191
Fax:(+212) 5 37 68 19 31
Article citation:
Rahmouni B,Alaoui K,Bouidida El-H,Chammache M,Taleb MS,Cherrah Y,Idrissi A. Acute toxicity, analgesic activity of Nepetagranatensis essential oil. J Pharm Biomed Sci. 2015; 05(02):110-117. Available at www.jpbms.info
ABSTRACT:
To evaluate the acute toxicity and the peripheral and central analgesic activity of the genus Nepeta, we studied the essential oil of Nepetagranatensis Boiss spontaneous species of Morocco. We have obtained the essential oil of N. granatensis by microwave irradiation and identified by GC-MS.
Female mice IOPS ofa,20-30g,were used to study the acute toxicity, as well as for the peripheral analgesic activity (Koster test). However, the study of the central analgesic activity (tail flick test) was conducted on rats Waster 250-350g. Doses of 25mg/kg and 50mg/kg of EO were administered intraperitoneally for both peripheral and central analgesic activities.The identification of the EO led to 25 constituent whose nepetalactone is the major product.The essential oil revealed a LD50 of 1000mg/kg. Koster test has shown a major protective power against abdominal cramps 74, 11 % at 25mg/kg and reached 86.77 % at 50mg/kg. However, the reflex time in the tail flick test exceeded the threshold of pain inhibition, which reached 8.46 s for the 50mg/kg dose.
EO had proved a low acute toxicity, and a great potential analgesic activity type ASA and morphine- like at 50mg/kg, which is probably due to its richness in nepetalactone
KEYWORDS: Acute toxicity; Analgesic activity; Essential oil; Microwave; Nepetagranatensis; nepetalactone.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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10.Srifi A, Rahmouni B, Bouidida El H, Alaoui K, Y Cherrah Y, Il Idrissi A, et al.Etude phytochimique et activité antifongique in vitro des huiles essentielles de quatre espèces du genre Nepeta du Maroc. Phytothérapie.2013; 11: 161-71.
11.Nizam B, Sajid N, Sajid B. In vitro antileishmanial,cytotoxic activity and phytochemical Analysis of Nepetapraetervisa leaves extract and its fractions.Int J Pharm PharmSci.2013;5(4) : 475-8.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015. Rahmouni B, Alaoui K, Bouidida El-H, Chammache M, Taleb MS, Cherrah Y, IL Idrissi A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Sushma Katkuri1,*,Shaheda Begum2
Affiliation:
1Assistant Professor, Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, India
2Medical Intern, Deccan College of Medical Sciences, Hyderabad, India
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, India
2.Deccan College of Medical Sciences, Hyderabad, India
Address reprint requests to
Dr Sushma Katkuri.
House No-9 Bhavya Shri Krishna Avenue,
Pragathi Nagar, Quthbulapur Mandal, Hyderabad-500090, India
Article citation:
Katkuri S,Begum S. Occupational exposure to blood and body fluids among health care workers in teaching hospital, Hyderabad, India. J Pharm Biomed Sci.2015;05(02):95-99. Available at www.jpbms.info
ABSTRACT:
Occupational Exposure to blood and body fluids among health care workers in teaching hospital in Hyderabad
Background: Needle stick injury means penetrating stab wound, introducing blood or other potentially hazardous material into the body of healthcare worker, during the performance of their duties, by a hollow bore needle or sharp instruments, including, needles, lancets, scalpels, and contaminated broken glass. According to the WHO, out of 35 million health workers worldwide, about 3 million receive percutaneous exposures to blood borne pathogens each year; two million of those to HBV, 0.9 million to HCV and 170 000 to HIV. Aims & Objectives: To determine the incidence of occupational exposures to blood and body fluids.
Materials & Methods: A cross-sectional study was conducted at Owaisi and Princess Esra Hospital, a Tertiary level, teaching hospital of Deccan College of Medical Sciences, Hyderabad, Andhra Pradesh, India. The study was done over a period of two months from April 2013-May 2013 with a sample of 150 health workers.
Results: Majority of the subjects were doctors contributing to 58.6% in which 33.3% were surgeons and 25.3% were non-surgeons were as 21% were nurses, 10% lab technicians, 7% operation theater assistants and 4% vaccinators. Out of 150 subjects 56% had needle stick injury in the past was as 44% didn’t have injury. The vaccination status about hepatitis B was good nearly 3/4th was vaccinated with hepatitis B & 1/4th were non-vaccinated.
Conclusion: A infection control committee should be formed in each and every health institute where medical staff can report their injuries and can get adequate counseling and guidance from them in handling the sharps.
KEYWORDS: Needle sticks injury; health care workers; blood borne.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the
manuscript represents honest and original work.
REFERENCES
1.NIOSH. Preventing needle stick injuries in health care settings. U.S. Department of health and human services. Cincinnati: DHHS (NIOSH) publication 1999.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
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Copyright © 2015. Katkuri S, Begum S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.