DocumentsDate added
Research article
WEN Shaohong1,†, OU Jinlai2,†, LUO Rui1, LIANG Wenli1, OUYANG Ping1,
ZENG Fen1, CHEN Yanwen1, XU Zhenxia1, ZHAO Wen1, LI Sha1,*
Affiliation:
1Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2Department of Preparation, Sunshinelake Pharma co., LTD., Shenzhen 523871, Guangdong, China
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2. Department of Preparation, Sunshinelake Pharma co., LTD., Shenzhen 523871, Guangdong, China
† Authors contributions: Both WEN Shaohong and OU Jinlai contributed equally to this work.
Address reprint requests to
LI Sha.
Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China or at tlisha@jnu.edu.cn
Article citation:
Shaohong W, Jinlai OU,R Luo, Wenli L, Ping O, Fen Z,Yanwen C,et al. Preparation and release behavior of pectin nanoparticles loading doxorubicin. J Pharm Biomed Sci. 2015; 05(05):385-393. Available at www.jpbms.info
ABSTRACT: Doxorubicin (DOX) is a highly efficient and broad-spectrum antitumor drug in the treatment of solid tumors. However, DOX can lead to a wide range of biochemical effects on human including inevitable toxicity to the normal tissues which has limited its clinical application. Nanoparticles, as a new kind of vehicle for antitumor drug delivery, can greatly enhance the theraputic effect and reduce the drug toxicity. In this work, we chose pectin (PEC) as carrier material to prepare DOX loading nanoparticles. The blank PEC nanoparticles (PEC-NPs) were prepared by emulsification-ionotropic gelation method and the formulation was optimized by central composite design and response surface method. The drug was loaded in PEC-NPs to obtain DOX loading pectin nanoparticles (DOX-PEC-NPs) by adsorption. The drug loading capacity of PEC-NPs was chiefly affected by ratio of DOX to PEC. The time, pH value and temperature of adsorption showed some influence on drug loading. Both PEC-NPs and DOX-PEC-NPs were sphere-like in shape with a mean diameter of (266.93 ± 1.70) nm and (287.70 ± 1.21) nm, respectively. The entrapment efficiency and drug loading rate of DOX-PEC-NPs was (91.71 ± 0.50)% and (17.17 ± 0.24) %, respectively. Compared with DOX, DOX-PEC-NPs showed apparent sustained release behavior with a burst release, which followed the double exponential diphase kinetics equation well.
KEYWORDS: Doxorubicin; Pectin; Nanoparticles; Drug loading; Drug release.
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Shaohong W,Jinlai OU,R Luo,Wenli L,Ping O,Fen Z,Yanwen C, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
LIANG Wenli1,†, LI Linlin2,†, LUO Rui1, XU Weihao1, TANG Yu1, XU Zhenxia1, ZHAO Wen1,NI Peihong3, LI Sha1,*
Affiliation:
1Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2The Fourth People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China
3Guangzhou Toplink Gene Bio-Engineering Co. Ltd.,Guangzhou 510000, China
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2.The Fourth People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China
† Authors contributions: Both LIANG Wenli and LI Linlin contributed equally to this work.
Address reprint requests to
LI Sha.
Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
Article citation: W Liang, L Li, R Luo, W Xu, Y Tang, Z Xu, et al. Preparation and characterization of diclofenac sodium sustained-release solid dispersion. J Pharm Biomed Sci. 2015; 05(05):394-402.Available at www.jpbms.info
Original article
Rajendra K Gupta1,*, MD, Gautam L Nagori2.,MD, Poonam Nagori3.,MSc, Ram P Patidar4.,DCH
Affiliation:
1,2Associate Professor Pediatrics Jhalawar Medical College Jhalawar Rajasthan India 326001
3Demonstrator Physiology, Jhalawar Medical College Jhalawar Rajasthan India 326001
4Senior Resident Pediatrics, Jhalawar Medical College Jhalawar Rajasthan India 326001
The name of the department(s) and institution(s) to which the work should be attributed:
Jhalawar Medical College, Jhalawar, Rajasthan India 326001
Address reprint requests to
Dr Rajendra Kumar Gupta.
III/1 Medical College Residence
Near IMA Hall, Jhalawar Rajasthan India 326001 or at rajdrchild@rediffmail.com
Article citation:
Gupta RK, Nagori GL, Nagori P, Patidar RP. Pattern of co-morbidities in children with severe acute malnutrition admitted in MTC of a teaching hospital of south east Rajasthan, India. J Pharm Biomed Sci. 2015; 05(05):403-407. Available at www.jpbms.info
ABSTRACT: Objective: To study the pattern of co-morbidities in children having Severe Acute Malnutrition in MTC attached to a teaching hospital.
Methods: In a span of two years all the children (421), admitted in MTC of SRG Hospital Medical College Jhalawar, were studied for presence of one or more co-morbid conditions along with severe acute malnutrition.
Results: Out of the 421 children who were admitted to Malnutrition Treatment Corner (MTC), acute respiratory infection is the most common (37.3%) co-morbidity in children with Severe Acute Malnutrition. Followed by acute gastrointestinal infection. Significant number of children was having urinary tract infections. Tuberculosis was diagnosed in 23% of children. Pyogenic skin infections were found in 14.7% cases. As micronutrient deficiencies present as part of Protein Energy Malnutrition, vitamin deficiencies of all vitamins A, C, D and B group were found in 28% of children and 87% of children were having anemia. Malaria and measles were also diagnosed in few study subjects, but they were not considered as significant co-morbid conditions
Conclusions: It is imperative to suspect and anticipate co-morbid condition in these children. High index of suspicion for these co-morbidities is the key to reduce mortality and better outcome in children having acute severe malnutrition.
KEYWORDS: Co-morbidities; Infections; MTC; SAM.
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Source of funding: None
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Gupta RK,Nagori GL,Nagori P,Patidar RP. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Lakshminarasimhaiah* and Rakesh Kumar Meel
Affiliation:
Goenka College of Pharmacy, Village: Ghassu, NH-11, PO: Khuri Bari, Lachhmangarh, Sikar District, Rajasthan, India-332313
The name of the department(s) and institution(s) to which the work should be attributed:
Goenka College Of Pharmacy, Vill: Ghassu, NH-11, PO: Khuri Bari, Lachhmangarh, Sikar District, Rajasthan, India-332313
Address reprint requests to
Lakshminarasimhaiah,
Goenka College OF Pharmacy, Vill: Ghassu, NH-11, PO: Khuri Bari, Lachhmangarh, Sikar District, Rajasthan, India-332313
Article citation: Lakshminarasimhaiah, Meel RK. Isolation of new phytoconstituents from Actiniopteris radiata. J Pharm Biomed Sci. 2015; 05(05):436-439. Available at www.jpbms.info
ABSTRACT:
Two new phytoconstituents have been isolated from petroleum ether extract of the whole plant of Actiniopteris radiata. The petroleum ether extract was subjected to column chromatography and isolated the phytoconstituents. Two new phytoconstituents were characterised by TLC, IR, UV spectral analysis, NMR and Mass spectra. Compound 1 is Dec-3-enyl, 2-(heptyloxy)-1-mercaptpoethyl terephthalate and compound 2 is 1-(Phenylethyl butanoate ether), 2-(3-ene heptanoate) ethane.
KEYWORDS: Actiniopteris radiata; Column chromatography; Polypodiaceae; Terephthalate.
REFERENCES
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2.Bhambie S, Tiwari H. P and George C. X. Chemical analysis Actiniopteris radiata. Cur Sci 1972;41(21): 788.
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4.Yoshihiro Mimaki, Kazuki Watanabe, Yuka Ando, Chiseko Sakuma and Yutaka Sashida. Flavonol glycosides and steroidal saponins from the leaves of Cestrum nocturnum and their cytotoxicity. J Nat Prod 2001; 64:17-22.
5.Chien-Chih Chen, Yu-Lin Huang, Chu-Wen Wang and Jun-Chih Ou. Water soluble glycosides from Ruta graveolens. J Nat Prod 2001; 64:990-992.
6.Alsuko Itoh, Takao Tanahashi, Naotaka Nagakura, Yukiko Takenaka, Cheng-Chang Chen and Jury Pelletier. Flavonoid glycosides from Adina racemosa and their inhibitory activities on eukaryotic protein synthesis. J Nat Prod 2004; 67:427-431.
7.Nabil Semmar, Bernard Fenet, Katia Gluchoff-Fiasson, Aurangzeb Hasan and Maurice Jay. Four new flavonol glycosides from the leaves of Astragalus caprinus. J Nat Prod 2002;65:576-579.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Lakshminarasimhaiah, Meel RK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
LUO Rui1,†, LUO Xiaojuan2,†, SUN Ning1,†, PU Yumei1, WANG Peihui1, RAN Danni1, XU Zhenxia1, ZHAO Wen1,,NI Peihong3, LI Sha1,*
Affiliation:
1Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2The Fourth People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China
3Guangzhou Toplink Gene Bio-Engineering Co. Ltd.,Guangzhou 510000, China
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2.The Fourth People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China
† Authors contributions: LUO Rui, LUO Xiaojuan and SUN Ning contributed equally to this work.
Address reprint requests to
LI Sha.
Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
Article citation:
R Luo, X Luo, N Sun, Y Pu, P Wang, D Ran, et al. Influence of composition and physical aging treatment on properties of free ethyl cellulose film. J Pharm Biomed Sci. 2015; 05(05):372-379. Available at www.jpbms.info
ABSTRACT:
Film coating by insoluble polymer materials is one of the most commonly used methods to control drug release in sustained and controlled release preparations. The composition, aging process and the stability of coating film significantly affect the drug release behavior. Ethyl cellulose (EC), a derivative of cellulose insoluble in water, is widely used as film coating material to realize sustained and controlled release. In this work, the properties of free EC film, including mechanical properties, water uptake and water vapor transmission (WVT), were investigated for different film composition after treatment under different aging and storage condition. As the concentration of plasticizers in the film increased, the tensile strength descended with a raise of elongation at breakage. Compared with the domestic EC films, imported EC films had a smaller tensile strength and higher elongation at breakage. The water uptake and WVT capacity decreased with the extension of aging time while increased with the enhancement of plasticizer concentration. The imported EC films showed a generally less water uptake and WVT capacity than domestic EC films. With the extension of aging time, the tensile strength of the films prepared with different plasticizers increased while the elongation at breakage decreased. The water uptake and WVT of the films was reduced as well. The sort and concentration of plasticizers, the sort of EC and the aging time had a great impact on the properties of free EC films. The preparations coated with imported EC may be stable than those with domestic EC.
KEYWORDS: Ethyl cellulose film; Plasticizer; Aging time; Mechanical properties; Water uptake; Water vapor transmission.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: This research was supported by the Guangzhou science and technology project (2013J4400061) to LI Sha and the Guangzhou Liwan District science and technology project (20134415049) to LI Sha.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 R Luo,X Luo,N Sun,Y Pu,P Wang,D Ran,et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.