DocumentsDate added
Original article
Lakshminarasimhaiah* and Rakesh Kumar Meel
Affiliation:
Goenka College of Pharmacy, Village: Ghassu, NH-11, PO: Khuri Bari, Lachhmangarh, Sikar District, Rajasthan, India-332313
The name of the department(s) and institution(s) to which the work should be attributed:
Goenka College Of Pharmacy, Vill: Ghassu, NH-11, PO: Khuri Bari, Lachhmangarh, Sikar District, Rajasthan, India-332313
Address reprint requests to
Lakshminarasimhaiah,
Goenka College OF Pharmacy, Vill: Ghassu, NH-11, PO: Khuri Bari, Lachhmangarh, Sikar District, Rajasthan, India-332313
Article citation: Lakshminarasimhaiah, Meel RK. Isolation of new phytoconstituents from Actiniopteris radiata. J Pharm Biomed Sci. 2015; 05(05):436-439. Available at www.jpbms.info
ABSTRACT:
Two new phytoconstituents have been isolated from petroleum ether extract of the whole plant of Actiniopteris radiata. The petroleum ether extract was subjected to column chromatography and isolated the phytoconstituents. Two new phytoconstituents were characterised by TLC, IR, UV spectral analysis, NMR and Mass spectra. Compound 1 is Dec-3-enyl, 2-(heptyloxy)-1-mercaptpoethyl terephthalate and compound 2 is 1-(Phenylethyl butanoate ether), 2-(3-ene heptanoate) ethane.
KEYWORDS: Actiniopteris radiata; Column chromatography; Polypodiaceae; Terephthalate.
REFERENCES
1.Bhambie S and George C. X. Studies in Pteridophytes. Cur Sci 1972; 41(7), 258-260.
2.Bhambie S, Tiwari H. P and George C. X. Chemical analysis Actiniopteris radiata. Cur Sci 1972;41(21): 788.
3.Taneja S. C and Tiwari H. P. Chemical constituents of Actiniopteris radiata. Cur Sci 1974; 43(23):749-750.
4.Yoshihiro Mimaki, Kazuki Watanabe, Yuka Ando, Chiseko Sakuma and Yutaka Sashida. Flavonol glycosides and steroidal saponins from the leaves of Cestrum nocturnum and their cytotoxicity. J Nat Prod 2001; 64:17-22.
5.Chien-Chih Chen, Yu-Lin Huang, Chu-Wen Wang and Jun-Chih Ou. Water soluble glycosides from Ruta graveolens. J Nat Prod 2001; 64:990-992.
6.Alsuko Itoh, Takao Tanahashi, Naotaka Nagakura, Yukiko Takenaka, Cheng-Chang Chen and Jury Pelletier. Flavonoid glycosides from Adina racemosa and their inhibitory activities on eukaryotic protein synthesis. J Nat Prod 2004; 67:427-431.
7.Nabil Semmar, Bernard Fenet, Katia Gluchoff-Fiasson, Aurangzeb Hasan and Maurice Jay. Four new flavonol glycosides from the leaves of Astragalus caprinus. J Nat Prod 2002;65:576-579.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Lakshminarasimhaiah, Meel RK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
LUO Rui1,†, LUO Xiaojuan2,†, SUN Ning1,†, PU Yumei1, WANG Peihui1, RAN Danni1, XU Zhenxia1, ZHAO Wen1,,NI Peihong3, LI Sha1,*
Affiliation:
1Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2The Fourth People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China
3Guangzhou Toplink Gene Bio-Engineering Co. Ltd.,Guangzhou 510000, China
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2.The Fourth People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China
† Authors contributions: LUO Rui, LUO Xiaojuan and SUN Ning contributed equally to this work.
Address reprint requests to
LI Sha.
Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
Article citation:
R Luo, X Luo, N Sun, Y Pu, P Wang, D Ran, et al. Influence of composition and physical aging treatment on properties of free ethyl cellulose film. J Pharm Biomed Sci. 2015; 05(05):372-379. Available at www.jpbms.info
ABSTRACT:
Film coating by insoluble polymer materials is one of the most commonly used methods to control drug release in sustained and controlled release preparations. The composition, aging process and the stability of coating film significantly affect the drug release behavior. Ethyl cellulose (EC), a derivative of cellulose insoluble in water, is widely used as film coating material to realize sustained and controlled release. In this work, the properties of free EC film, including mechanical properties, water uptake and water vapor transmission (WVT), were investigated for different film composition after treatment under different aging and storage condition. As the concentration of plasticizers in the film increased, the tensile strength descended with a raise of elongation at breakage. Compared with the domestic EC films, imported EC films had a smaller tensile strength and higher elongation at breakage. The water uptake and WVT capacity decreased with the extension of aging time while increased with the enhancement of plasticizer concentration. The imported EC films showed a generally less water uptake and WVT capacity than domestic EC films. With the extension of aging time, the tensile strength of the films prepared with different plasticizers increased while the elongation at breakage decreased. The water uptake and WVT of the films was reduced as well. The sort and concentration of plasticizers, the sort of EC and the aging time had a great impact on the properties of free EC films. The preparations coated with imported EC may be stable than those with domestic EC.
KEYWORDS: Ethyl cellulose film; Plasticizer; Aging time; Mechanical properties; Water uptake; Water vapor transmission.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: This research was supported by the Guangzhou science and technology project (2013J4400061) to LI Sha and the Guangzhou Liwan District science and technology project (20134415049) to LI Sha.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 R Luo,X Luo,N Sun,Y Pu,P Wang,D Ran,et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Adithi S Shetty1 , MS ,Harish Shetty2 , MD , Divya Hegde3 , MS, B. Suresh Kumar Shetty 4, MD , Jagadish Rao Padubidri 5,*, MD, Diplomate NB
Affiliation:
1Assistant Professor, Department of Obstetrics and Gynecology, Kasturba Medical College, Mangaluru (Affiliated to Manipal University), India.
2Professor and Head,Department of Obstetrics and Gynecology, K.S.Hegde Medical Academy, Mangaluru, India.
3Assistant Professor, Department of Obstetrics and Gynecology, A J Institute of Medical Sciences, Mangaluru, India.
4Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Mangaluru (Affiliated to Manipal University), India
5*Associate Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Mangaluru (Affiliated to Manipal University), India
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Obstetrics and Gynecology, Kasturba Medical College, Mangaluru (Affiliated to Manipal University), India.
2.Department of Obstetrics and Gynecology, K.S.Hegde Medical Academy, Mangaluru, India.
3.Department of Obstetrics and Gynecology, A J Institute of Medical Sciences, Mangaluru, India.
4,5Department of Forensic Medicine and Toxicology, Kasturba Medical College, Mangaluru (Affiliated to Manipal University), India
Address reprint requests to
Dr. Jagadish Rao Padubidri.
Associate Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Light House Hill Road, Mangaluru (Affiliated to Manipal University), India or at ppjrao@gmail.com
Article citation: Shetty AS, Shetty H, Hegde D, Shetty BSK, Padubidri JR. Yolk sac abnormalities – Is it a reliable indicator of abortions? – A prospective study in the population residing in rural setup of Mangaluru, Karnataka, India. J Pharm Biomed Sci. 2015; 05(05):380-384. Available at www.jpbms.info
ABSTRACT: Objective: This study was undertaken to determine if there were different abortion rates between normal and abnormal yolk sacs between 5-10 weeks of gestation, its association with pregnancy outcome and correlation with other parameters
Materials and Methods: In this study, the yolk sac characteristics of 95 consecutive pregnant women, of 5-6.5 weeks gestation, with normal body mass index (BMI) were prospectively evaluated. All patients underwent two-dimensional transvaginal ultrasonography, which was performed by the same sonographer. We considered the following yolk sac characteristics as normal for classification: diameter: 2-5 mm; round shape; absence of degenerative changes. Yolk sacs that had diameters smaller than 2 mm or larger than 5 mm; a shape that was not round (i.e., oval or distorted); the presence of degenerative changes. The outcome is statistically analyzed.
Results: A total of 100 cases were evaluated. Five cases were excluded. 81(85.3%) continued beyond 20 weeks and the rest 14(14.7%) ended in abortions. About 95.7% of the pregnancies showed the presence of a yolk sac, while in 4.3% of them a yolk sac was absent. Pregnancies with large yolk sac diameter ended with abortions. The sensitivity of predicting normal outcome with regular yolk sac is as high as 94.2%, while specificity is 34.5%.
Conclusions: Abnormalities of the yolk sac size or shape, and absence can be used as a reliable indicators of early pregnancy.
KEYWORDS: Normal Yolk Sac; Abnormal Yolk Sac; Spontaneous Abortion; Transvaginal Ultrasound.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
REFERENCES
1.Cepni I, Bese T, Os cal P, Budak E,IdiM,AksuMF, Significanceof yolk sac with vaginal sonography in the first trimester in the prediction of pregnancy outcome. Acta Obstetriciaet Gynacologca Scandenevia 1997; 76:969-972.
2.Lindsay DJ, Lovett IS, Lyons EA et al. Yolk sac diameter and shape at endovaginal US: predictors of pregnancy outcome in the first trimester. Radiology. 1992; 183:115-118.
3.Küçük T, Duru NK, Yenen MC, Dede M, Ergün A, Başer I. Yolk sac size and shape as predictors of poor pregnancy outcome. J Perinat Med. 1999; 27: 316-320.
4.Khaled S. Mousa, Amr Mohamed El- Helaly and Mahmoud Abd El-Aziz. The Value of Yolk Sac Diameter at Vaginal Ultrasonography as a Predictor of the First Trimester Pregnancy Outcome. Life Sci J. 2014; 11:236-240.
5.Tan S, Ipek A, Pektas MK, Arifoğlu M, Teber MA, Karaoğlanoğlu M. Irregular yolk sac shape: is it really associated with an increased risk of spontaneous abortion? J Ultrasound Med. 2011; 30:31-36.
6.Varelas FK, Prapas NM, Liang RI, Prapas IM, Makedos GA. Yolk sac size and embryonic heart rate as prognostic factors of first trimester pregnancy outcome. Eur J Obstet Gynecol Reprod Biol. 2008; 138:10-13.
7.Cho FN, Kan YY, Chen SN, Yang TL, Hsu PH. Very large yolk sac and bicornuate uterus in a live birth. J Chin Med Assoc. 2005; 68:535-537.
8.Tongsong T, Wanapirak C, Srisomboon J, Sirichotiyakul S, Polsrisuthikul T, Pongsatha S.Transvaginal ultrasound in threatened abortions with empty gestational sacs. Int J Gynaecol Obstet.1994; 46: 297-301.
9. Chama CM, Marupa JY, Obed JY. The value of the secondary yolk sac in predicting pregnancy outcome. J Obstet Gynaecol.2005; 25: 245-247.
10.Berdahl DM, Blaine J, Van Voorhis B, Dokras A. Detection of enlarged yolk sac on early ultrasound is associated with adverse pregnancy outcomes. Fertil Steril. 2010; 94: 1535-1537.
11.Malinowski W. Yolk sacs in twin pregnancy. Ginekol Pol. 2000; 71:815-818.
12.Błaszczyk K, Wojcieszyn M, Biernat M, Lukasik A, Wilk M, Poreba R. Predicting the risk of poor pregnancy outcome by ultrasound examination of yolk sac diameter. Ginekol Pol. 2000; 71: 699-703.
13.Nyberg DA, Mack LA, Laing FC, Patten RM. Distinguishing normal from abnormal gestational sac growth in early pregnancy. J Ultrasound Med 1987; 6:23-27.
14.Rowling SE, Coleman BG, Langer JE, Arger PH, Nisenbaum HL, Horii SC. First-trimester US parameters of failed pregnancy. Radiology. 1997; 203:211-217.
Source of funding: No Funding
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Shetty AS, Shetty H, Hegde D, Shetty BSK, Padubidri JR. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
WEN Shaohong1,†, OU Jinlai2,†, LUO Rui1, LIANG Wenli1, OUYANG Ping1,
ZENG Fen1, CHEN Yanwen1, XU Zhenxia1, ZHAO Wen1, LI Sha1,*
Affiliation:
1Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2Department of Preparation, Sunshinelake Pharma co., LTD., Shenzhen 523871, Guangdong, China
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
2. Department of Preparation, Sunshinelake Pharma co., LTD., Shenzhen 523871, Guangdong, China
† Authors contributions: Both WEN Shaohong and OU Jinlai contributed equally to this work.
Address reprint requests to
LI Sha.
Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China or at tlisha@jnu.edu.cn
Article citation:
Shaohong W, Jinlai OU,R Luo, Wenli L, Ping O, Fen Z,Yanwen C,et al. Preparation and release behavior of pectin nanoparticles loading doxorubicin. J Pharm Biomed Sci. 2015; 05(05):385-393. Available at www.jpbms.info
ABSTRACT: Doxorubicin (DOX) is a highly efficient and broad-spectrum antitumor drug in the treatment of solid tumors. However, DOX can lead to a wide range of biochemical effects on human including inevitable toxicity to the normal tissues which has limited its clinical application. Nanoparticles, as a new kind of vehicle for antitumor drug delivery, can greatly enhance the theraputic effect and reduce the drug toxicity. In this work, we chose pectin (PEC) as carrier material to prepare DOX loading nanoparticles. The blank PEC nanoparticles (PEC-NPs) were prepared by emulsification-ionotropic gelation method and the formulation was optimized by central composite design and response surface method. The drug was loaded in PEC-NPs to obtain DOX loading pectin nanoparticles (DOX-PEC-NPs) by adsorption. The drug loading capacity of PEC-NPs was chiefly affected by ratio of DOX to PEC. The time, pH value and temperature of adsorption showed some influence on drug loading. Both PEC-NPs and DOX-PEC-NPs were sphere-like in shape with a mean diameter of (266.93 ± 1.70) nm and (287.70 ± 1.21) nm, respectively. The entrapment efficiency and drug loading rate of DOX-PEC-NPs was (91.71 ± 0.50)% and (17.17 ± 0.24) %, respectively. Compared with DOX, DOX-PEC-NPs showed apparent sustained release behavior with a burst release, which followed the double exponential diphase kinetics equation well.
KEYWORDS: Doxorubicin; Pectin; Nanoparticles; Drug loading; Drug release.
REFERENCES
1.Gong LS, Zhang YD, Zhou SB. The Biodistribution of magnetic albumin nanoparticles containing doxorubicin in rats[J]. China Journal of Modern Medicine. 2001;11(3):8-10.
2.Menon SK, Mistry BR, Joshi KV, et a1. Analytical detection and method development of anticancer drug Gemcitabine HCl using gold nanoparticles[J]. Spectrochim Acta A Mol Biomol Spectrosc. 2012; 10(94A):235-242.
3.Stein W, Bates S, Fojo T. Intractable cancers: the many faces of multidrug resistance and the many targets it presents for therapeutic attack. Current Drug Targets. 2004;5(4):333-346.
4.Kingsley JD, Dou H, Morehead J, et al. Nanotechnology: a focus on nanoparticles as a drug delivery system[J]. Journal of Neuroimmune Pharmacology. 2006;1(3):340-350.
5.Joseph MM, Aravind SR, George SK, et al. Anticancer activity of galactoxyloglucan polysaccharide-conjugated doxorubicin nanoparticles: Mechanistic insights and interactome analysis. Eur J Pharm Biopharm. 2015; 93:183-195.
6.You JO. Efficient gene delivery with calcium-alginate nanoparticles[D]. University of Southern California. 2006.
7.Mao SJ, Hou SX, Zhang LK. Preparation and liver targeting properties of glycyrrhizic acid surface modified Valaciclovir albumin nanoparticles[J]. Journal of Biomedical Engineering. 2004;21(4):570-574.
8.Chen J, Hu Q, Hou ZQ, et al. Chitosan nanoparticles prepared by ion induction combined with chemical crosslinking method and preliminary studies about its being a targeting control-released carrier for drugs[J]. Chinese Pharmaceutical Journal. 2010; (18): 1400-1403.
9.Xu H, Hu FQ, Ying XY, et al. Preparation of evaluation of in vitro and in vivo of alginate nanoparticles loading insulin[J]. Chinese Pharmaceutical Journal. 2006; 41(6): 434-437.
10.Zhou XY, Shen Q, Li ML, et al. Preparation of Saussurea nanoparticles by multiple emulsion method[J]. Lishizhen Medicine and Materia Medica Research. 2010; 21(7):1726-1727.
11.Vanderwaal RP, Griffith CL, Wright WD. Delaying S-phase progression rescues cells from heat-induced S-phase hypertoxicity[J]. Journal of Cellular Physiology. 2001;14(2):81-82.
12.Taheri A, Dinarvand R, Atyabi F, et al. Targeted delivery of methotrexate to tumor cells using biotin functionalized methotrexate human serum albumin conjugated nanoparticles[J]. J Biomed Nanotechnol. 2011;7(6):743-753.
13.Widder KJ, Marino PA, Morris RM. Selective targeting of magnetic albumn microspheres to the yoshida Sarcoma: Ultrastructural evaluation of microsphere disposition[J]. European Journal of Cancer & Clinical Oncology. 1983;(1):96-98.
14.Brusentsov NA, Gogosov VV, Brusentsova TN. Evaluation of ferromagnetic fluids and suspensions for the site-specific radiofrequency-induced hyperthermia of MX11 sarcoma cells in vitro[J]. Journal of Magnetism and Magnetic Materials. 2001;11(2):934-940. 15.Ashford M, Fell J, Attwood D. Enhanced pectin degradation in the presence of calcium-implications for colonic delivery[J]. Proc Int Symp Controlled Release Bioact Mater. 1994; 21:750-751.
16.Sriamornsak P. Chemistry of pectin and its pharmaceutical uses: A review[J]. Silpakorn University International Journal. 2003;3(1-2):206-228.
17.Mishra R, Banthia A, Majeed A. Pectin based formulations for biomedical applications: A review[J]. Asian Journal of Pharmaceutical & Clinical Research. 2012;5(4):1-7.
18.Liu L, Fishman ML, Kost J, et al. Pectin-based systems for colon-specific drug delivery via oral route[J]. Biomaterials. 2003;24(19):3333-3343.
19.Sriamornsak P. Application of pectin in oral drug delivery[J]. Expert opinion on drug delivery. 2011; 8(8):1009-1023.
20.Yoshimura T, Sengoku K, Fujioka R. Pectin-based surperabsorbent hydrogels crosslinked by some chemicals: Synthesis and characterization[J]. Polymer bulletin. 2005; 55(1-2):123-129.
21.Cheng K, Lim L-Y. Insulin-loaded calcium pectinate nanoparticles: Effects of pectin molecular weight and formulation pH[J]. Drug development and industrial pharmacy. 2004;30(4):359-367.
22.Glinsky VV, Raz A. Modified citrus pectin anti-metastatic properties: One bullet, multiple targets[J]. Carbohydrate research. 2009; 344(14):1788-1791.
23.Li S, Wang XT, Zhang XB, et al. Studies on alginate-chitosan microcapsules and renal arterial embolization in rabbits[J]. Journal of Controlled Releaase. 2002;84(3):87-98.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Shaohong W,Jinlai OU,R Luo,Wenli L,Ping O,Fen Z,Yanwen C, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
M.Bharathi1,*, MD (Microbiology), M.Radha2, M.Sc(Geography), M.Sc.(Botany),B.Ed.
Affiliation:
1Associate Professor, Department of Microbiology, Rajeev Gandhi Institute of Medical Sciences (RIMS), Kadapa, AP, India
2School Assistant, Biology, Queen Mary’s Government High School for Girls, Visakhapatnam, AP, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, Rajeev Gandhi Institute of Medical Sciences (RIMS), Kadapa, AP, India
Address reprint requests to
Dr.M.Bharathi
Associate Professor, Department of Microbiology, Rajeev Gandhi Institute of Medical Sciences (RIMS), Kadapa, AP, India
Article citation:
Bharathi M, Radha M. Awareness & knowledge of adolescent girl students from a government high school for girls on HIV/AIDS. J Pharm Biomed Sci. 2015; 05(05):408-414.Available at www.jpbms.info
ABSTRACT:
India has the 3rd highest number of estimated people living with HIV/AIDS (PLHA) in the world. It is estimated that over 35% of all reported HIV incidences in India occur among young people of 15-24yrs of age. Despite norms prohibiting premarital sex relations, opportunities to form premarital relations did exist and 4% young women had engaged in premarital sex. Adolescent girls are at far greater risk of contracting HIV than boys, as a result of their greater physiological susceptibility and their vulnerability to sexual violence, rape and marriages at an early age.
Aim: 1.To evaluate awareness and knowledge of adolescent girl students about HIV/AIDS.
2.To assess the impact of curriculum on HIV/AIDS, on the knowledge of students about HIV/AIDS.
Material & Methods: 150 students from 10th standard, having a lesson on HIV/AIDS ( group one) and 150 students from 9th standard, not having a lesson on HIV/AIDS (group two) were included. Formative evaluation was done. Selection type, closed ended, objective type schedule in Telugu language, was administered. Schedule contained 12 items.
Statistical Analysis: Chi square test was used.
Results: General awareness as, HIV is a virus and it causes AIDS was high in both groups. 59.33% & 66.66% from group one and 29.33% & 44% of group two knew how HIV spreads and how it does not spread, respectively. Group one had more knowledge on symptoms than group two. Above all are with significant P values. There was not much difference in the knowledge of two groups about its non-curability and lack of vaccine. Only 16.66% from both groups has positive attitude towards PLHA. Group one had more awareness about high risk group. Text books/Teachers were the main source of information.
Conclusions: (1)The awareness and knowledge of 10th Std. students on HIV/AIDS was higher than that of 9th Std. students.(2)Curriculum on HIV/AIDS played an important role on the awareness and knowledge of students on HIV/AIDS. (3)Positive attitude towards PLHA was less. (4)The awareness, as HIV/AIDS has no cure and no vaccine was also less.
(5)Teachers & Text books were on top as source of information.
KEYWORDS: Adolescents; Attitude; adolescent education programme; Curriculum; Reproductive health.
REFERENCES
1.Anurag Srivastava, Syed Esam Mahmood, Payal Mishra, V.P.Shrotria, Iram Shaifali “Adolescenc Awareness: A Better tool to combat HIV/AIDS” National Journal of Community Medicine, 2011, 2(1): 86-90.
2.NACO Annual Report 2013-14 (30-6-14): India’s voice against AIDS, Dept. of AIDS control, Ministry of H&FW, GOI.
3.NACP Phase 4 “Youth and Adolescent : Working Group” Draft Report June 2011 G).
4.Smriti Naswa and Y.S.Marfatia “Adolescnt HIV/AIDS: Issues and Challenges. Indian J Sex Transm Dis 2010 Jan-June; 31 (1): 1-10.
5.The State of The World’s Children 2011 UNICEF (2011).
6.United Nations: General Assembly, 65th Session, Political Declaration on HIV & AIDS on 8-7-2011 (A/RES/65/277.
7.Girls, HIV/AIDS and Education: UNICEF December 2004 (www.unicef.org).
8.National Family Health Survey-3 conducted in 2005-2006 by IIPS under the aegis of GOI.
9.Dr.Shikha Trivedi. HIV/AIDS Awareness level in Secondary Schools of India after twenty seven years. IOSR Journal of Humanities and Social Science, March 2014;19(3):ver2:pp 71-75.
10.A.E.Oyo-Ita, B.M.Ikpeme, A.J.Etokidem, J.B.Offor, E.O.Okokon, and S.J.Etuk. Knowledge of HIV/AIDS Among Secondary School Adolescents in Calabar- Nigeria. Annals of African Medicine, 2005; 4 (1): 2-6.
11.S.Bhalla, H.Chandwani, D.Singh, C.Somasundaram, S.K.Rasania and S.Singh. Knowledge about HIV/AIDS Among Senior Secondary School Students in Jamnagar, Gujarat. Health and Population – Perspectives and Issues, 2005; 28 (4): 178-188.
12.P.Lal, Anita Nath, S.Badhan and Gopal K Ingle. A Study of Awareness about HIV/AIDS Among Senior Secondary School Children of Delhi. Indian J Community Med, July 2008; 33(3): 190-192.
13.Jannu Raja Mouli, Bolla Chandra Sekhar Reddy, A.Rajeswara Rao, and K.Mallikharjuna Rao. To Assess the Knowledge regarding HIV/AIDS Among Secondary School and Junior College Students in Khammam town of Andhra Pradesh Int J Res Health Sci (IJHRS), April 2014; 2(2): 511-6.
14.Suneeth Pramanik, Maggie Chartier and Cheryl Koopman “HIV/AIDS Stigma & Knowledge among Predominantly Middle class High School Students in New Delhi, India. J Commun. Dis, 2006; 38 (1): 57-69.
15.Basir Gaash, Muzaffar Ahmad, Rehana Kasur and Shabnam Bashir. Knowledge, Attitude and Belief on HIV/AIDS Among Female Senior Secondary School Students in Srinagar district of Kashmir. Health and Population–Perspectives and Issues 2003; 26 (3): 101-109.
16.Arindam Chakrovarty, Saswati Nandy, Rabindranadh Roy, Bhaswati Sengupta, Sukanta Chatterjee, Ramendra Narayan Choudhuri. A Study of Awareness on HIV/AIDS Among higher Secondary School Students in Central Kolkata.Indian J Community Med, 2007;32(3):228-229.
17.R T Sudha, DT Vijay, V Lakshmi. Awareness, Attitudes and Beliefs of the General Public towards HIV/AIDS in Hyderabad, a Capital city from South India. Indian J Med Sci 2005; 59 (7): 307-16.
18.Bounbouly Thanavanh, Md Harun-Or-Rashid, Hideki Kasuya and Junichi Sakamoto. Knowledge, Attitudes and Practices regarding HIV/AIDS among male High School Students in Lao Peoples Democratic Republic. Journal of International AIDS Society 2013; 16:17387. (http://www.jiasociety.org/index.php/jias/article/view/17387.
19.Sanam Jindal. Awareness about HIV/AIDS in selected Pre-university colleges in Moodbidri: A cross sectional study. Asian Journal of Pharmaceutical and Clinical Research 2003; 6(1):208-210.
20.Alexndra McManus and Lipi Dhar. Study of Knowledge, Perception and Attitude of Adolescent girls towards STIs/HIV, Safer Sex and Sex Education: (A Cross Sectional Survey of urban Adolescent girls in South Delhi, India). BMC Women’s Health, 2008; 8:12 doi:10.1186/1472-6874-8-12.
21.Murtala Mohammad Ruma. Knowledge and Awareness of HIV/AIDS Among Some Senior Secondary School Children in Katsina, Nigeria. Bayero Journal of Pure and Applied Sciences 2009; 2(2):121-126.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Bharathi M, Radha M. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.