DocumentsDate added
Original article
Oluwatosin K. Shittu1, Bashir Lawal1,*, Asmau N. Abubakar1, Eustace B. Berinyuy2, ,Busari B. Musa3, Ibrahim A Olalekan4.
Affiliation:
1Tropical Disease Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B.65, Minna, Nigeria
2Faculty of medicine and Biomedical Science, University of Yaounde 1, Cameroon
3Centre for Genetic Engineering and Biotechnology, Global Institute for Bioexploration Unit, Federal University of Technology Minna, Nigeria.
4Forestry Technology Department Federal College of Wild Life Management, New Bussa, Niger State, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
1.Tropical Disease Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B.65, Minna, Nigeria
2.Faculty of medicine and Biomedical Science, University of Yaounde 1, Cameroon
3. Centre for Genetic Engineering and Biotechnology, Global Institute for Bioexploration Unit, Federal University of Technology Minna, Nigeria.
4. Forestry Technology Department Federal College of Wild Life Management, New Bussa, Niger State, Nigeria
Address reprint requests to
* Bashir Lawal.
Department of Biochemistry, Tropical Disease Research Unit, Federal University of Technology, P.M.B. 65, Minna, Nigeria.
Phone no: +234 -8165112378
Article citation: Shittu OK, Lawal B, Abubakar AN, Berinyuy BE, Busari MB, Ibrahim AO. Toxicological implications of methanol extract from Nigerian Bee propolis on some selected rat tissues. J Pharm Biomed Sci. 2015; 05(07):524-531. Available at www.jpbms.info
ABSTRACT: Objectives: The present study investigates the effects of Nigerian bee propolis on some biochemical indices in some selected rat tissues. Methods: A total of Fifteen wistar rats were grouped into 3(A-C) of 5 rats each. Group A rats serve as control groups and received 0.5ml of DMSO, while groups B and C received 300 and 600 ml/kg of methanol extract of honey bee propolis respectively, for 21 days through oral route.
Results: The extract significantly increased (p<0.05) the Spleen and small intestine ALT activities, kidney and small intestine AST activities, kidney ALP activities as well as the level of total protein in Liver and spleen of bee propolis treated rats. In contrast, the Liver and spleen AST activities, and liver ALP activities decrease significantly (p<0.05) in bee propolis treated rats when compared with their corresponding controls. However, the spleen and small intestine ALP activities, level of kidney and small intestine total protein as well as ALT activities in the kidney of bee propolis treated rats compared well (p>0.05) with the normal value at the extract doses studied. The computed liver, kidney, and small intestine body weight ratios of rats treated with the extract does not differ(p>0.05) with those of the control rats, however, increase in spleen/body weight in propolis treated rats than the control group was observe.
Conclusion: The chronic administration of methanol extracts of bee propolis altered the normal values of some biochemical parameters in rat organs. Clinical application of the bee propolis should therefore be carefully controlled as it chronic administration may be relatively unsafe for the integrity of organs.
KEYWORDS: Propolis; Liver; Kidney; Spleen; Small intestine; Biomarker enzyme; Total proteins.
REFERENCES
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Shittu OK, Lawal B, Abubakar AN, Berinyuy BE, Busari MB, Ibrahim AO. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Moumita Mondal1,*, Swamya Soman1,*, Renukaradhya K. Math1,§
Affiliation:
1,*Master of Science in Biotechnology, §Ph.D Department of Biotechnology, Garden City College, 16 KM, Old Madras Road, Bangalore-560049, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biotechnology, Garden City College, 16 KM, Old Madras Road, Bangalore-560049, India
Address reprint requests to
* Renukaradhya K. Math.
Department of Biotechnology, Garden City College, 16 KM, Old Madras Road, Bangalore-560049, India
*Moumita and Swamya contributed equally
Article citation: Mondal M, Soman S, Math RK. Evaluation Of antibacterial activity Of methanol and acetone extracts (different parts) of moringa oleifera and hibiscus rosasinensis. J Pharm Biomed Sci. 2015; 05(07):532-538. Available at www.jpbms.info
ABSTRACT: Methanol and acetone extract of two plant genus; Moringa oleifera and Hibiscus rosa-sinensis was carried out to identify the particular part of plant having antibacterial activities and also analyze phytochemicals constituents. Crude extracts were tested for antibacterial activity with concentrations of 200 and 300μg/ml. Acetone extracts of Moringa oleifera seed (MOS) and Moringa oleifera fruit pulp (MOFP) showed significant antibacterial activity against test organisms; for S.aureus, P.aeroginosa at 20 μg/ml and for E.coli, and S.typhi at 300μg/ml. While, methanol extracts of MOS and MOFP also shown activity against test organism except against S.typhi at 300μg/ml. Meanwhile, among Hibiscus rosa-sinensis leaf (HRL), Hibiscus rosa-sinensis flower petal (HRFP) and Hibiscus rosa-sinensis flower clayx (HRFC), only HRFC of acetone and methanol extracts shown significant activity at 300 μg/ml against S.aureus, E.coli and P.aeroginosa but no activity was shown against S.typhi. Surprisingly, methanol and acetone extracts of leaf extracts from both the plants did not show any activity on test organism. Subsequently, phytochemical analysis of acetone extracts supposed that compounds like, methionine, moringine, nitriles, isothiocynate, thiocarbonates and saponins might be involved in inhibiting the bacterial growth. Thus, seeds and pulp of M. oleifera & calyx of H. rosa-sinensis can be used as potential sources to extract antimicrobial agents possessing medicinal values.
KEYWORDS: Moringa oleifera; Hibiscus rosa-sinensis; organic solvents; antimicrobial activity; phytochemicals.
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: Garden City Education Trust, Bangalore-560049, India
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Mondal M, Soman S,Math RK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Shetgar Anupama1, Patil Brijesh2, Anandi Vinut3 ,Gill Kanwarpal Singh4
Affiliation:
1Assistant Professor, Department of Ophthalmology, 2Associate Professor, Department of Ophthalmology, 3Resident, Department of Ophthalmology,4Resident, Department of Ophthalmology S.Nijalingappa Medical College, Bagalkot, Karnataka, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Ophthalmology S.Nijalingappa Medical College, Bagalkot, Karnataka, India
Abstract:
Aim: To determine the epidemiological characteristics and risk factors predisposing to infective keratitis in Bagalkot, Karnataka, India.
Methods: All patients with suspected infective keratitis attending ophthalmology outpatient department at Hanagal Shri Kumareshwar hospital from First of October 2014 were accessed. Sociodemographic data and risk factors were recorded. Corneal scrapings and samples were sent for microbiological assessment.
Results: In 3 month period 50 cases with infective keratitis were documented and accessed. 64% males being the majority with middle aged working population as prime section.
65% had predisposing trauma as history with 43% attended hospital within 1st week of event.76% sought medical help. Among them 52% had fungal pathogen, 43% had bacterial pathogen, 5% had mixed aetiological agents.
Conclusion: Infective keratitis being the commonest cause for corneal opacity, most oftenly occurs after an episode of trauma with agricultural products or tools.
KEYWORDS: Infective keratitis; Risk factors; Health facility; Bagalkot.
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Shetgar A, Patil B, Anandi B,Gill KS. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report and review of literature
Jigar M Dhuvad1,*,Rajesh A Kshirsagar2,Mukesh M Dhuvad3
Affiliation:
1Assistant Professor, Government Dental College and Hospital, Ahmedabad, India.
2Professor and Head, Bharati Vidyapeeth Dental College and Hospital, Pune, India
3Private practiconer, Ahmedabad, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune, India
Address reprint requests to
* Dr Jigar M Dhuvad (MDS)
D-34; Ishan-1; Behind Seema Hall, Satellite, Ahmedabad, India or at drjigardhuvad1981@gmail.com
Article citation: Dhuvad JM, Kshirsagar RA, Dhuvad MM. Mucormycosis: An opportunistic fungal infection in uncontrolled diabetic patients: Experience of two cases and a review of literature. J Pharm Biomed Sci. 2015; 05(07):583-588. Available at www.jpbms.info
ABSTRACT: Mucormycosis, also known as zygomycosis, is an opportunistic fulminant fungal infection, which mainly affects the immunocompromised patients. The infection begins in the nose and paranasal sinuses due to inhalation of fungal spores. It has six predominant clinical forms: rhinocerebral, central nervous system, pulmonary, cutaneous, gastrointestinal, disseminated, and uncommon (i.e., heart, bone, kidney, mediastinum, bladder, and oral). Although oral involvement of this condition has been reported relatively frequently in the literature, we report two cases of mucormycosis in an uncontrolled diabetic patient. Because of its rapid progression and high mortality, early diagnosis of this potentially fatal fungal infection along with aggressive treatment offers the only chance to increase the survival rates. The purpose of this article is to report our clinical experience with two cases of mucormycosis of the maxilla in relation with uncontrolled diabetes mellitus and a review of the literature in relation to various types of mucormycosis.
KEYWORDS: Central nervous system; fungal infections; maxilla; mucormycosis.
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Copyright © 2015 Dhuvad JM, Kshirsagar RA, Dhuvad MM. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.