DocumentsDate added
Original article
Pujar Chaitra1*, Patil Brijesh2, Nayana KS3
1* Assistant professor, Department of Ophthalmology, S Nijalingappa Medical College and Hanagal Shri Kumareshwar Hospital and Research Center, Navanagar, Bagalkot
2 Associate professor, Department of
Ophthalmology, S Nijalingappa Medical College and Hanagal Shri Kumareshwar Hospital and Research Center, Navanagar,Bagalkot
3 Junior resident, Department of Ophthalmology, S Nijalingappa Medical College and Hanagal Shri Kumareshwar Hospital and Research Center, Navanagar, Bagalkot
Address reprint requests to
*Pujar Chaitra,
Assistant professor, Department of Ophthalmology, S Nijalingappa Medical College and
Hanagal Shri Kumareshwar Hospital and Research Center, Navanagar, Bagalkot.
Article citation: Pujar C, Patil B, Nayana SK. What patients want to know before they undergo cataract surgery: a prospective study. J Pharm Biomed Sci 2015;05(09): 760–764. Available at www.jpbms.info
Purpose: To determine what patients want to know before undergoing cataract surgery in our hospital where most patients come from surrounding rural areas.
Materials and Methods A written questionnaire translated in local language was answered by 200 patients who were booked for cataract surgery.
Results Our study included 54%male and 46% female patients. Information regarding chances of vision improvement, when will the vision improve, overall risk of losing vision
and types of serious complication were given importance. Ninety-eight per cent patients wanted to be warned about complications happening in 1 in 50 and 51% wanted to be warned about complication happening in 1 in 1000. Ninety-eight per cent patients wanted all information verbally explained, only 9.5% wanted to be informed through videos. It was observed in our study that most patients of age 51–60 preferred to get information about the surgery and its complication before surgery. Most female patients felt it was not important to give information about the surgery and its complication.
Conclusion Most patients wanted to know about the chances of vision improvement and serious complications. Female patients wanted the doctor to decide their treatment
and did not desire information prior to surgery which explains illiteracy and ignorance of health in women of rural areas.
KEYWORDS cataract surgery, complications, information, losing vision, risk, rural area,
visual improvement
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Swathimutyam Pallerla, Bala Prabhakar*
Affiliation:
Department of Pharmaceutics, Shobhaben Pratapbhai Patel, School of Pharmacy & Technology Management SVKM’S NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai – 400056 India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Pharmaceutics, Shobhaben Pratapbhai Patel, School of Pharmacy & Technology Management SVKM’S NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai – 400056 India
Address reprint requests to
*Dr. Bala Prabhakar.
Associate Dean & Senior Professor
Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management SVKM’S NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai – 400056
Article citation: Pallerla, S.,Prabhakar, B. Development and validation of Temozolomide solid lipid nanoparticle formulation by RP-HPLC method. J Pharm Biomed Sci. 2015;05(09):745-749. Available at www.jpbms.info
ABSTRACT: The present study was designed to develop newer method forsolid lipid nanoparticles with Temozolomide as anti-cancer drug. The method was carried out using C-18 kromasil (ODS column 250mm × 4.6 mm I.D.; particle size 5μm with mobile phase consisting of methanol: 0.5% glacial acetic acid in the ratio (20:80). The flow rate at 1.0 ml/min and effluent was detected at 316 nm. The retention time of temozolomide was observed at 6.32 minutes. The method was validated for specificity, accuracy, precision, linearity, and limit of detection, limit of quantification, robustness and solubility. LOD and LOQ of solid lipid nanoparticles temozolomide were 0.8µg/ml and 2µg/ml respectively. The calibration curve was linear in the concentration range of 10-70 μg/ml with coefficient correlation of 0.999. The percentage recovery for the temozolomide was 99.8% and % RSD was less than 1 %. There are scanty reports with relation to determination of temozolomide in solid lipid nanoparticle formulation. The proposed method was used for quantitative determination of temozolomide in solid lipid nanoparticles and is validated using various parameters.
KEYWORDS: Temozolomide, anti-cancer drug, methanol,0.5% glacial acetic acid, solid lipid nanoparticles, HPLC; validation.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Pallerla, S., Prabhakar, B. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Famurewa Ademola C1,*, Kanu Shedrach C1, Uzoegwu Peter N2, Ogugua Victor N2
Affiliation:
1Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria, PMB 1010 Abakaliki, Nigeria
2Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria, PMB 1010 Abakaliki, Nigeria
2.Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria
Address reprint requests to
* Famurewa, Ademola Clement.
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo, Ebonyi State
Article citation: Famurewa, A.C., Kanu, S.C., Uzoegwu, P.N., Ogugua, V.N. Ameliorative effects of hibiscus sabdariffa extract against carbon tetrachloride-induced lipid peroxidation, oxidative stress and hepatic damage in rats. J Pharm Biomed Sci. 2015;05(09):725-732. Available at www.jpbms.info
ABSTRACT: Objective: Hibiscus sabdariffais a medicinal plant associated with beneficial health effects. The leaves and flowers are used as traditional drinks and medicines in countries. The current study aimed to investigate Hibiscus sabdariffa Linn methanolic extract ameliorative potential against carbon tetrachloride-induced lipid peroxidation, hepatic damage and oxidative stress.
Methods: Adult male Wistar rats were administered 2.5ml/kg body weight of CCl4 by oral gavage to induce oxidative stress 48 hours before administration of 200, 600 to 1000mg/kg doses of Hibiscus sabdariffa methanolic extract to group 3, 4 and 5, respectively for 10 days (n=5). Group 1 was used as negative control, while group 2 was used as positive-comparative control (2.5ml/kg CCl4). At the end of the experiment, serum glutathione (GSH), vitamin C and E, MDA, liver damage markers and antioxidant enzymes were analysed in all the groups.
Results: Carbon tetrachloride-induced oxidative stress in experimental rats was evidenced by increase in malondialdehyde (MDA) and reduction in SOD, catalase and reduced glutathione (GSH).Hibiscus sabdariffa extract treatment at 600 and 1000mg/kg doses resulted in significant modulation of antioxidant indices and alkaline phosphatase (p<0.05), but failed to demonstrate significant effects in AST, ALT and MDA. There were significant increases (p<0.05) in the serum vitamin C and E at 600 and 1000mg/kg doses of the extract.
Conclusion: The overall results suggest that hibiscus sabdariffa contains bioactive phytochemicals that may improve hepatic status and ameliorate oxidative damage at high doses in carbon tetrachloride intoxication.
KEYWORDS: Hibiscus sabdariffa; hepatic damage; lipid peroxidation; oxidative stress; phytochemicals.
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Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Original article
Brijesh A Patil1,*, Anupama C Shettgar1,€,Nanditha Arekal1,¥
Affiliation:
1,*Associate professor,1,€Assistant Professor,1,¥ 2nd year Post graduate, Department of Ophthalmology, SNMC, Bagalkot, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Ophthalmology, SNMC, Bagalkot, India
Address reprint requests to
* Dr Nanditha A M.
Post graduate, Department of Ophthalmology, SNMC, Bagalkot, India
Article citation: Patil, B.A.,Shettgar A.C.,Nanditha, A.M. A clinical study to determine the efficacy of ultrasonic biometry and SRK II formula in calculation of IOL power. J Pharm Biomed Sci. 2015;05(09):719-724. Available at www.jpbms.info
ABSTRACT: The aim of the study was to estimate the post-operative refraction with IOL implanted by using A-scan biometry and SRK II formula, to determine the difference between estimated and actual post-operative refractive error,to determine the range of deviation of post-operative refractive error from expected refraction encountered by using this method.
Methods: The study was carried out in 100 patients admitted in HSK hospital, Bagalkot undergoing extracapsular cataract extraction with posterior chamber intraocular lens implantation. IOL power was calculated using SRK II formula. The aim was to make the patient slightly myopic. The expected post-operative refraction was subtracted from the spherical correction for distance. This gives deviation of post-operative refraction from expected value. The results thus obtained were tabulated in the proforma and master table and analysed.
Results: Using A scan biometry and SRK II formula the accuracy of IOL prediction was as follows-76 percent patients had errors within ±1D, Ninety five within± 2D and ninety eight within ±3D.
Conclusion: A Scan biometry with SRK II formula is recommended as an accurate method of IOL power calculation for desired postoperative refraction.
KEYWORDS: a-scan biometry; intraocular lens power calculation; SRK II formula.
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5.Sanders DR, Retzlaff JA, Kraff MC, et al. Comparison of SRK/T formula and other theoretical and regression formulas. J Cat and Refract Surg 1990;16:341-46.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Majority of the information gathered are from media sources which don’t reflect the author’s own opinion.
Copyright © 2015 Patil B.A.,Shettgar A.C.,Nanditha A.M. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.