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Case Report
Ambarisha Bhandiwad1, Surakshith L. Gowda2*
1Professor and Head, Department of OBG,JSS Medical College, JSS University,Mysore, Karnataka, India
2Junior Resident, Department of OBG, JSS Medical College, JSS University, Mysore,Karnataka, India
Address reprint requests to
*Dr. Surakshith L. Gowda,
No. 140/4, 2nd Cross, Shankarmutt road, Fort Mohalla,Mysore 570004, Karnataka, India
Article citation: Bhandiwad A, Gowda SL.Hepatitis E in pregnancy: a case report.J Pharm Biomed Sci 2015;05(10):797–798.Available at www.jpbms.info
ABSTRACT Viral hepatitis is one of the most common infectious diseases in developing countries. Hepatitis E in particular has a wide geographical variation and it either occur
as epidemics or seen as sporadic cases. Mainly when pregnant women are affected with Hepatitis E, the disease will be more severe if the women is in second or third trimester,
particularly in third trimester, where chances of fulminant hepatic failure is more with high mortality rates. Here we are presenting a case of acute viral hepatitis complicating pregnancy
where the women goes into spontaneous labour and almost ends in postpartum hemorrhage. Due to timely intervention by transfusing blood components the possible
harm was prevented. Each patient can behave in different way so the plan of management should be tailor made to each patient.
KEYWORDS Viral hepatitis, hepatitis E, pregnancy, fulminant hepatic failure, postpartum haemorrhage, component therapy
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Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Loudjedi Salim1*, Bereksi Amian1, Khemis Kamila2, Dib Fadel3, Toaba Toaba1,
Taouagh Nacereddine1, Kherbouche Mouffok1
1 Hospital of Tlemcen, Department of Medicine, University of Tlemcen, Algeria
2 Department of GBM, University of Tlemcen, Algeria
3 Hospital of Tlemcen Gastroenterology,Department of Medicine, University of Tlemcen, Algeria
Address reprint requests to
*Dr. Loudjedi Salim,
Hospital of Tlemcen,
Department of Medicine, University of Tlemcen, Algeria
Article citation: Salim L, Amian B, Kamila K, Fadel D, Toaba T, Nacereddine T, Mouffok K. Evidence-based medicine in biliary surgery: a model of applicability. J Pharm Biomed Sci 2015;05(10):807–811.Available at www.jpbms.info
Abstract:
Background Evidence-based medicine (EBM) is the conscientious and judicious use of the best data in the literature for optimal care of patients. This must go through four steps: (1) formulation of a clear clinical question, (2) research documented facts, (3) analysis of results and (4) application of results in clinical practice.
Methods Our choice of application was gallstones and complications because it is a frequent and complex pathology that requires several clinical questions. The experimental design was considered to be a non-comparative cohort study (patients were exposed to evidence-based medicine). It can also be considered as a feasibility study. In our application we took the following steps: (1) formulation of several clinical questions, (2) literature search in medline using MeSH and Cochrane library, (3) analysis of results through critical reading of collected articles, (4) calculation of percentage of patients for each clinical situation and correlating it with the levels of evidence. Then we estimated the matching of our application with EBM by calculating the number of positive responses.
Conclusion As a conclusion we were able to apply EBM with some degrees of confidence.
However, some limitations related to environmental factors are still present. We can overcome this problem by introducing an educational learning model.
KEYWORDS EVIDENCE-based medicine, gallstones, non-comparative, cohort, education
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Moulshree Kohli1,Puneet Ahuja2, Amit Gupta3*
1 Post graduate student, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
2 Prof & Head, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
3Senior Lecturer, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
Address reprint requests to
*Dr. Amit Gupta,
Department of Oral and Maxillofacial Pathology and Microbiology, ITS Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
Article citation: Kohli M, Ahuja P, Gupta A. EVALUATION OF DIFFERENT DECALCIFYING AGENTS ON ORAL HARD TISSUES:A COMPARATIVE STUDY.J Pharm Biomed Sci 2015;05(10):804–806. Available at www.jpbms.info
Introduction Decalcification of bone and teeth is often an essential and important step during tissue processing. The rate of decalcification and the effect of various decalcifying agents on the tissue and their staining characteristics are two important parameters influencing the selection of decalcifying solutions. Some decalcifying agents, although they completely and rapidly remove the calcium ions also adversely affect the staining characteristics and may cause damage to the organic components. This study aimed to EVALUATE the efficacy of the commonly used demineralizing agents to identify the best decalcifying agent. Materials and Methods Three decalcifying agents namely, 10 percent nitric acid, 10 percent hydrochloric acid and 10 percent formic acid were used to decalcify 30 natural teeth.The endpoint of decalcification was EVALUATED by physical and chemical methods. The decalcified teeth were subjected to routine processing and staining with hematoxylin and eosin stains.
Result Formic acid of 10% was the most considerate to the hard tissues and 10% hydrochloric acid was the least considerate to the tooth structure.
Conclusion Formic acid of 10% though being the slowest decalcifying agent, gave excellent results for soft-tissue integrity and staining characteristics.
KEYWORDS 10% nitric acid, 10% hydrochloric acid, 10% formic acid, decalcifying agents
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original Article
Ahmed M. Hamdan*
Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
Liposomes are drug delivery systems that may increase the penetration of lipophilic compounds through the skin, enhancing their topical effect. Voriconazole (VRC) is a broad-spectrum trizole antifungal medication that is active against invasive aspergillosis, candidiasis and certain emerging fungal infections. In this study, we formulated different compositiosof liposomal preparations for VRC and we EVALUATED the physical characteristics of these preparations including vesicular shape, vesicular size, drug entrapment efficiency, drug loading capacity and drug release properties of VRC.
KEYWORDS antifungal, voriconazole (VRC), liposomes, formulation
Address reprint requests to
*Ahmed Mohsen Hamdan, Department of Pharmaceutics, Faculty of Pharmacy,University of Tabuk, Tabuk, KSA
E-mail: a_hamdan@ut.edu.sa
Article citation: Hamdan AM. Design,formulation and characterization of liposomal preparation of voriconazole (VRC). J Pharm Biomed Sci 2015;05(10):822–827. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: Deanship of Scientific Research (DSR), University of Tabuk, Tabuk,Saudi Arabia, under the grant number S/1436/0102.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Acknowledgement: The authors would like to acknowledge financial support for this work from the Deanship of Scientific Research (DSR), University of Tabuk, Tabuk, Saudi Arabia, under the grant number S/1436/0102.
Case Report
Amit Gupta1*, Puneet Ahuja2, Swyeta Jain Gupta3,Vivek Gautam4,Vivek Rai5
1Senior Lecturer, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
2 Prof & Head, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
3Senior Lecturer, Department of Periodontics and Implantology, I.T.S.Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India
4MDS,Prosthodontics (Private practitioner),Gautam Multispeciality Dental Clinic,P N Plaza Complex, Below Bank Of India,Sigra, Varanasi, Uttar Pradesh, India
5 MDS, Endodontics, Private Practitioner,Lucknow,Uttar Pradesh, India
Address reprint requests to
Dr. Amit Gupta,
Department of Oral and Maxillofacial Pathology and Microbiology,
I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
Article citation: Gupta A, Ahuja P,Gupta SJ, Gautam V, Rai V. Critical role of tumor marker biology in the assessment of radiotherapy as a therapeutic modality in oral squamous cell carcinoma. J Pharm Biomed Sci 2015;05(10):799–806. Available at www.jpbms.info
ABSTRACT Despite advances in oncology therapeutics and biomedical research that have transformed since the turn of this century and deepened our understanding of cancer hallmarks, resulting in the discovery and development of targeted therapies, the success rates of oncology drug development remain low. Opportunities have increased with the understanding of molecular basis of the cancer translating to the discovery, development and availability of targeted therapies that have brought meaningful benefit to patients with diverse malignancies. One of the most challenging aspects of head and neck oncology is the selection of the most appropriate treatment for an individual patient with squamous cell carcinoma. The encouraging results from neoadjuvant chemotherapy and radiotherapy for patients with larger tumours, call for the identification of new accurate predictors of response to radiotherapy so that the appropriate therapy can be tailored better for individual patients.
KEYWORDS radiotherapy, squamous cell carcinoma, tumour markers
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Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.