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Original Article
Ahmed M. Hamdan*
Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
Liposomes are drug delivery systems that may increase the penetration of lipophilic compounds through the skin, enhancing their topical effect. Voriconazole (VRC) is a broad-spectrum trizole antifungal medication that is active against invasive aspergillosis, candidiasis and certain emerging fungal infections. In this study, we formulated different compositiosof liposomal preparations for VRC and we EVALUATED the physical characteristics of these preparations including vesicular shape, vesicular size, drug entrapment efficiency, drug loading capacity and drug release properties of VRC.
KEYWORDS antifungal, voriconazole (VRC), liposomes, formulation
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*Ahmed Mohsen Hamdan, Department of Pharmaceutics, Faculty of Pharmacy,University of Tabuk, Tabuk, KSA
E-mail: a_hamdan@ut.edu.sa
Article citation: Hamdan AM. Design,formulation and characterization of liposomal preparation of voriconazole (VRC). J Pharm Biomed Sci 2015;05(10):822–827. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: Deanship of Scientific Research (DSR), University of Tabuk, Tabuk,Saudi Arabia, under the grant number S/1436/0102.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Acknowledgement: The authors would like to acknowledge financial support for this work from the Deanship of Scientific Research (DSR), University of Tabuk, Tabuk, Saudi Arabia, under the grant number S/1436/0102.
Review article
Mudiyanse Rasnayaka Mudiyanselage
Department of Pediatrics, Faculty of Medicine,University of Peradeniya, Sri Lanka
Address reprint requests to
Mudiyanse RM,
Department of Pediatrics,
Faculty of Medicine, University of Peradeniya, Sri Lanka
Article citation: Mudiyanse RM. Safe marriage for prevention of thalassaemia:Sri Lankan experience, appraisal of the concepts and challenges of implementation.J Pharm Biomed Sci 2015;05(10):791–796. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all
the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
PManohar B. Kachare1* Sanjay B. Kulkarni2
1 Associate Professor, Bharati Vidyapeeth Medical College, Sangli, Maharastra, India
2 Vishrambag Hospital Sangli, Maharastra, India
Address reprint requests to
*Dr Manohar B. Kachare, MD,
Ultravision diagnostic Centre, Jaysingpur, Tal. Shirol
Dist, Kolhapur, Maharastra 416101, India
Article citation: Manohar BK, Sanjay BK. Ultrasound-guided aspiration and polidocanol foam sclerotherapy of cystic lesions: study of 20 cases. J Pharm Biomed Sci 2015;05(10):777–781. Available at www.jpbms.info
Objectives To perform a retrospective study to eualuate the aspiration and polidocanol sclerotherapy in the management of various cystic lesions in the body.
Materials and Methods Twenty patients with symptomatic cystic lesions in the body were aspirated and injected with Polidocanol foam under ultrasound guidance. Thyroidcyst (2), intraabdominal lymphatic cyst (1), epididymal cyst (1), urachal duct remnant cyst(1), simple liver cyst (1), cystic liver metastasis (1), simple renal cyst (4), adrenal cyst (1),
congenital funicular hernia (1), encysted hydrocele of spermatic cord (1), hydrocele (2), ovarian cysts (2), angular dermoid cyst (1), and hydronephrotic kidney secondary to PU junction obstruction (1). All patients were followed up by ultrasonography up to 6 months
after treatment.
Results In all the patients, sclerotherapy was performed on an outpatient basis under local anesthesia and none of the patients needed postoperative analgesia or admission.
Nineteen out of 20 patients had complete regression of the lesions, one patent with multiple cystic liver mets in postoperative case of jejunal gastrointestinal stromal tumuor (GIST), approximately 70–80% regression of the size of cystic lesions in the liver was
noted. None of the patients had any complication and none required analgesia. All the patients were discharged 1 hour after the procedure.
Conclusion Ultrasound-guided aspiration and foam sclerotherapy with polidocanol is an effective, safe, and minimally invasive therapeutic option for symptomatic cystic lesions
in the body with equal efficacy and lower morbidity and hospital stay as compared with surgical options.
KEYWORDS ultrasound, cystic lesions, polidocanol, sclerosants.
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Sudipta Kar*
Sr. Lecturer, Department of Paedodontics & Preventive Dentistry, Guru Nanak Institute of Dental Sciences & Research, Kolkata 114, West Bengal, India
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*Sudipta Kar,
21F, Charakdanga Road, Uttarpara, Hooghly 712258,
West Bengal, India
Article citation: Sudipta K. A COMPARATIVE PREALENCE STUDY OF ORAL HABIT STATUS AMONG IVF AND SPONTANEOUSLY CONCEIVED CHILDREN OF WEST BENGAL. J Pharm Biomed Sci 2015;05(10):782–786. Available at www.jpbms.info
Objective In-Vitro fertilization is one of the modern treatments modality of infertility. Deleterious oral habits are the common problem often found by the dental surgeons during routine examination. Oral habits are repetitive behaviour in the oral cavity that exhibited in different ways like thumb sucking, lip sucking, nail biting, mouth breathing, tongue thrusting, handkerchief biting, etc. Development of oral habits may cause dentoalveolar and/or skeletal deformation in children and ultimately form, function, and aesthetics of orofacial region may be compromised.
Results The results showed that the PREVALENCE of oral habits in IVF children was 39.3%. Thumb sucking was relatively more common habit and seen in only 16.66% of IVF children.
Nail biting was found in 11.33%, handkerchief biting in 3.33%, and the result was significant at p < 0.05. Tongue thrusting (6%) and mouth breathing (2%) cases was relatively less common of IVF children and the result is not significant at p < 0.05 level. Presence of handkerchief biting is a unique finding of the present study.
Conclusion The deleterious oral habits restrict proper growth and development of orofacial structure of IVF children. So these kinds of habits should be interrupted and treated as early as possible.
KEYWORDS IVF children, oral habits, thumb sucking, mouth breathing, PREVALENCE, tongue thrusting, handkerchief biting
Key Messages: IVF children are more oral habit prone.
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Case Report
Kushal Baidya1, Abdul Wahid Khan1, Ajaz Suhaff1, Asma Manjoor1, Umar Majid2*
1 Department of Psychiatry, SKIMS Medical College and Hospital, Bemina, Srinagar, Kashmir India
2 Department of Pulmonary and Critical Care Medicine, SKIMS MC Hospital, Bemina, Srinagar, India
Address reprint requests to
*Dr. M Umar Majid,
Department of Pulmonary and Critical Care Medicine, SKIMS MC and Hospital Bemina,
Srinagar KMR, India.
Article citation: Baidya K, Khan AW, Suhaff A, Manjoor A, Majid U. Phobia with hallucinations in a patient with implantable cardioverter defibrillator: a case report. J Pharm Biomed Sci 2015;05(10):771–773.
ABSTRACT This case report describes a 21-year-old patient with implantable cardioverter defibrillator (ICD) diagnosed as phobia with prominent visual hallucinations which were incapacitating. He was treated with sertraline 200 mg/d and clonazepam 0.5 mg/d for 1 month after which his symptoms resolved. It was emphasized that patients with ICD are prone to develop psychiatric disorder and require special attention. Visual hallucinations developed may be present across different spectrum of disorders. Treating the underlying condition resolves hallucinations occurring without psychotic features.
KEYWORDS: visual hallucinations, phobia, anxiety disorder, ICD
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.