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Review article
Mudiyanse Rasnayaka Mudiyanselage
Department of Pediatrics, Faculty of Medicine,University of Peradeniya, Sri Lanka
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Mudiyanse RM,
Department of Pediatrics,
Faculty of Medicine, University of Peradeniya, Sri Lanka
Article citation: Mudiyanse RM. Safe marriage for prevention of thalassaemia:Sri Lankan experience, appraisal of the concepts and challenges of implementation.J Pharm Biomed Sci 2015;05(10):791–796. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all
the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
REFERENCES
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11.Ginsberg G, Tulchinsky T, Filon D, et al. Cost-benefit analysis of a national thalassaemia prevention programme in Israel. J Med Screen. 1998;5(3):120–6.
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13.Nasri NW, Jamal AR, Abdullah NC, et al. Preimplantation genetic diagnosis for beta-thalassemia using single-cell DNA analysis for codons 17 and 26 of beta-globin gene. Arch Med Res.2009;40(1):1–9.
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17.Yeo GS, Tan KH, Liu TC. Screening for beta thalassemia and HbE traits with the mean red cell volume in pregnant women. Ann Acad Med Singapore. 1994;23(3):363–6.
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Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
PManohar B. Kachare1* Sanjay B. Kulkarni2
1 Associate Professor, Bharati Vidyapeeth Medical College, Sangli, Maharastra, India
2 Vishrambag Hospital Sangli, Maharastra, India
Address reprint requests to
*Dr Manohar B. Kachare, MD,
Ultravision diagnostic Centre, Jaysingpur, Tal. Shirol
Dist, Kolhapur, Maharastra 416101, India
Article citation: Manohar BK, Sanjay BK. Ultrasound-guided aspiration and polidocanol foam sclerotherapy of cystic lesions: study of 20 cases. J Pharm Biomed Sci 2015;05(10):777–781. Available at www.jpbms.info
Objectives To perform a retrospective study to eualuate the aspiration and polidocanol sclerotherapy in the management of various cystic lesions in the body.
Materials and Methods Twenty patients with symptomatic cystic lesions in the body were aspirated and injected with Polidocanol foam under ultrasound guidance. Thyroidcyst (2), intraabdominal lymphatic cyst (1), epididymal cyst (1), urachal duct remnant cyst(1), simple liver cyst (1), cystic liver metastasis (1), simple renal cyst (4), adrenal cyst (1),
congenital funicular hernia (1), encysted hydrocele of spermatic cord (1), hydrocele (2), ovarian cysts (2), angular dermoid cyst (1), and hydronephrotic kidney secondary to PU junction obstruction (1). All patients were followed up by ultrasonography up to 6 months
after treatment.
Results In all the patients, sclerotherapy was performed on an outpatient basis under local anesthesia and none of the patients needed postoperative analgesia or admission.
Nineteen out of 20 patients had complete regression of the lesions, one patent with multiple cystic liver mets in postoperative case of jejunal gastrointestinal stromal tumuor (GIST), approximately 70–80% regression of the size of cystic lesions in the liver was
noted. None of the patients had any complication and none required analgesia. All the patients were discharged 1 hour after the procedure.
Conclusion Ultrasound-guided aspiration and foam sclerotherapy with polidocanol is an effective, safe, and minimally invasive therapeutic option for symptomatic cystic lesions
in the body with equal efficacy and lower morbidity and hospital stay as compared with surgical options.
KEYWORDS ultrasound, cystic lesions, polidocanol, sclerosants.
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Moulshree Kohli1,Puneet Ahuja2, Amit Gupta3*
1 Post graduate student, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
2 Prof & Head, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
3Senior Lecturer, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
Address reprint requests to
*Dr. Amit Gupta,
Department of Oral and Maxillofacial Pathology and Microbiology, ITS Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India
Article citation: Kohli M, Ahuja P, Gupta A. EVALUATION OF DIFFERENT DECALCIFYING AGENTS ON ORAL HARD TISSUES:A COMPARATIVE STUDY.J Pharm Biomed Sci 2015;05(10):804–806. Available at www.jpbms.info
Introduction Decalcification of bone and teeth is often an essential and important step during tissue processing. The rate of decalcification and the effect of various decalcifying agents on the tissue and their staining characteristics are two important parameters influencing the selection of decalcifying solutions. Some decalcifying agents, although they completely and rapidly remove the calcium ions also adversely affect the staining characteristics and may cause damage to the organic components. This study aimed to EVALUATE the efficacy of the commonly used demineralizing agents to identify the best decalcifying agent. Materials and Methods Three decalcifying agents namely, 10 percent nitric acid, 10 percent hydrochloric acid and 10 percent formic acid were used to decalcify 30 natural teeth.The endpoint of decalcification was EVALUATED by physical and chemical methods. The decalcified teeth were subjected to routine processing and staining with hematoxylin and eosin stains.
Result Formic acid of 10% was the most considerate to the hard tissues and 10% hydrochloric acid was the least considerate to the tooth structure.
Conclusion Formic acid of 10% though being the slowest decalcifying agent, gave excellent results for soft-tissue integrity and staining characteristics.
KEYWORDS 10% nitric acid, 10% hydrochloric acid, 10% formic acid, decalcifying agents
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original Article
Ahmed M. Hamdan*
Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
Liposomes are drug delivery systems that may increase the penetration of lipophilic compounds through the skin, enhancing their topical effect. Voriconazole (VRC) is a broad-spectrum trizole antifungal medication that is active against invasive aspergillosis, candidiasis and certain emerging fungal infections. In this study, we formulated different compositiosof liposomal preparations for VRC and we EVALUATED the physical characteristics of these preparations including vesicular shape, vesicular size, drug entrapment efficiency, drug loading capacity and drug release properties of VRC.
KEYWORDS antifungal, voriconazole (VRC), liposomes, formulation
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*Ahmed Mohsen Hamdan, Department of Pharmaceutics, Faculty of Pharmacy,University of Tabuk, Tabuk, KSA
E-mail: a_hamdan@ut.edu.sa
Article citation: Hamdan AM. Design,formulation and characterization of liposomal preparation of voriconazole (VRC). J Pharm Biomed Sci 2015;05(10):822–827. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: Deanship of Scientific Research (DSR), University of Tabuk, Tabuk,Saudi Arabia, under the grant number S/1436/0102.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Acknowledgement: The authors would like to acknowledge financial support for this work from the Deanship of Scientific Research (DSR), University of Tabuk, Tabuk, Saudi Arabia, under the grant number S/1436/0102.
Case Report
Mahendra Wawhal1,Vajed Mogal2*,Sandeep Sanap3,Atul Jadhav4
1 Associate Professor and Consultant,2,3 Senior Resident, 4Junior Resident Department of Medicine, MGM Medical College and Hospital, Aurangabad431003, Maharashtra, India
Address reprint requests to
*Dr. Vajed Mogal, Senior Resident,
Department of Medicine, M.G.M. Medical college and Hospital, Aurangabad 431003, Maharashtra, India
Article citation: Wawhal M, Mogal V,Sanap S, Jadhav A. Post-streptococcal reactive arthritis: a rare case report and a brief review of literature. J Pharm Biomed Sci 2015;05(10):774–776.Available at www.jpbms.info
ABSTRACT: We report the case of a 30-year-old woman who developed severe post-streptococcal reactive arthritis (PSRA) after a subclinical streptococcal infection. Anti-streptococcal antibody titres and clinical course confirmed the diagnosis. Coincidence of PSRA is rare in the adult population and the potential for misdiagnosis exists, particularly when prior streptococcal infection is not apparent. The clinical manifestations of post-streptococcal syndromes are highly variable, and the diagnosis of concomitant PSRA should be considered when patients present with inflammatory arthritis. Factors from both the host and the pathogen are probably important in determining disease expression in post-streptococcal syndromes.
KEYWORDS: post-streptococcal reactive arthritis, streptococcal infection
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.