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Original article
Megha Pawar*, Rabindra N. Misra, Nageswari R. Gandham, Kalpana Angadi, Savita Jadhav,Chanda Vyawahare, Swarupa Hatolkar
Department of Microbiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune 411018, Maharashtra, India
Address reprint requests to
*Megha Pawar,
Research scholar,
Department of Microbiology
Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune 411018,Maharashtra, India
Article citation: Pawar M, Misra RN,Gandham NR, Angadi K, Jadhav S,Vyawahare C, Hatolkar S. PREVALENCE AND ANTIFUNGAL SUSCEPTIBILITY PROFILE OF CANDIDA SPECIES ISOLATED FROM TERTIARY CARE HOSPITAL, INDIA. J Pharm Biomed Sci 2015;05(10):812–816.Available at www.jpbms.info
Abstract
Background The change in epidemiology and antifungal susceptibility has generated interest among clinical microbiologists in the identification of Candida up to species level along with antifungal susceptibility patterns. Objectives This study was undertaken to INVESTIGATE the PREVALANCE of Candida spp and its antifungal susceptibility from the various clinical samples.Materials and Methods Total of 317 clinical samples from various suspected fungal infections were received in the Department of Microbiology to investigate suspected Candidal infections. Isolation, identification and antifungal susceptibility were done by standard conventional methods.Results A total of 104 non-duplicate Candida species were isolated, out of which 37 (35.6%) were C. albicans and 67 (64.4) were non-C. albicans, and the remaining were C. tropicalis 35 (33.7%), C. glabrata 18 (17.3%) and C. parapsilosis 6 (5.8%). Maximum isolates were from sputum as well as body fluids followed by pus, tissue and urine. Antifungal susceptibility showed higher degree of resistance to Fluconazole (4%), followed by Clotrimazole (2%) and lower degree to Amphotericin B (1%). All isolates were susceptible to Ketoconazole, Voriconazole and Nystatin.
Conclusion An increase in the infections was caused by non-candida albicans species. Candida species identification and antifungal susceptibility are important for the treatment especially for those who hospitalise with serious underlying disease.
KEYWORDS antifungal susceptibility testing, Candida species, CHROM agar, Sabouraud’s dextrose agar (SDA)
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Review article
Mudiyanse Rasnayaka Mudiyanselage
Department of Pediatrics, Faculty of Medicine,University of Peradeniya, Sri Lanka
Address reprint requests to
Mudiyanse RM,
Department of Pediatrics,
Faculty of Medicine, University of Peradeniya, Sri Lanka
Article citation: Mudiyanse RM. Safe marriage for prevention of thalassaemia:Sri Lankan experience, appraisal of the concepts and challenges of implementation.J Pharm Biomed Sci 2015;05(10):791–796. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all
the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
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Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
PManohar B. Kachare1* Sanjay B. Kulkarni2
1 Associate Professor, Bharati Vidyapeeth Medical College, Sangli, Maharastra, India
2 Vishrambag Hospital Sangli, Maharastra, India
Address reprint requests to
*Dr Manohar B. Kachare, MD,
Ultravision diagnostic Centre, Jaysingpur, Tal. Shirol
Dist, Kolhapur, Maharastra 416101, India
Article citation: Manohar BK, Sanjay BK. Ultrasound-guided aspiration and polidocanol foam sclerotherapy of cystic lesions: study of 20 cases. J Pharm Biomed Sci 2015;05(10):777–781. Available at www.jpbms.info
Objectives To perform a retrospective study to eualuate the aspiration and polidocanol sclerotherapy in the management of various cystic lesions in the body.
Materials and Methods Twenty patients with symptomatic cystic lesions in the body were aspirated and injected with Polidocanol foam under ultrasound guidance. Thyroidcyst (2), intraabdominal lymphatic cyst (1), epididymal cyst (1), urachal duct remnant cyst(1), simple liver cyst (1), cystic liver metastasis (1), simple renal cyst (4), adrenal cyst (1),
congenital funicular hernia (1), encysted hydrocele of spermatic cord (1), hydrocele (2), ovarian cysts (2), angular dermoid cyst (1), and hydronephrotic kidney secondary to PU junction obstruction (1). All patients were followed up by ultrasonography up to 6 months
after treatment.
Results In all the patients, sclerotherapy was performed on an outpatient basis under local anesthesia and none of the patients needed postoperative analgesia or admission.
Nineteen out of 20 patients had complete regression of the lesions, one patent with multiple cystic liver mets in postoperative case of jejunal gastrointestinal stromal tumuor (GIST), approximately 70–80% regression of the size of cystic lesions in the liver was
noted. None of the patients had any complication and none required analgesia. All the patients were discharged 1 hour after the procedure.
Conclusion Ultrasound-guided aspiration and foam sclerotherapy with polidocanol is an effective, safe, and minimally invasive therapeutic option for symptomatic cystic lesions
in the body with equal efficacy and lower morbidity and hospital stay as compared with surgical options.
KEYWORDS ultrasound, cystic lesions, polidocanol, sclerosants.
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.