Property | Value |
Name | Synthesis and Antimicrobial Activity of New Heterocyclic Compounds |
Description | Research article
Lakshminarasimhaiah1,*, S. Alexander2
In the present investigation a series of pyrazole derivatives were synthesized by condensation of 8-acetyl, 7-hydroxy, 4-methyl coumarin (I) with substituted benzaldehyde to form chalkone (II). The obtained chalkone was treated with phenyl hydrazine to form pyrazole derivatives(IIIa-h). The synthesized compounds were characterized by IR, NMR, Mass spectra and Elemental analysis. New compounds were screened for their antimicrobial studies against S. aureus, B. subtilis, E. coli and P. aeruginosa. The results revealed that compound IIIe has ortho chlorophenyl substituent showed significant antibacterial activity against all tested microorganisms as compared to the standard drug Ceftriaxone. Keywords: Antimicrobial activity; chalkone; pyrazole; substituted benzaldehyde; spectral data.
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Filename | Lakshminarasimhaiah(422-426).pdf |
Filesize | 1.22 MB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 05/08/2014 00:00 |
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Maintained by | Editor |
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Last updated on | 05/12/2014 01:33 |
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