Property | Value |
Name | Risk Factors And Antibiotic Susceptibility Pattern Among Non-Fermenting Gram Negative Bacilli In A Teaching Hospital |
Description |
Original article MeghnaC1, SevithaBhat2,*,VidyalakshmiK3
Affiliation:- 1Post graduate, 2Associate Professor, 3Additional Professor, Department of Microbiology, Kasturba Medical College, Mangalore-575001, Karnataka, India
The name of the department(s) and institution(s) to which the work should be attributed: Department of Microbiology, Kasturba Medical College, Mangalore-575001, Karnataka, India
Address reprint requests to Dr SevithaBhat. Associate Professor, Department of Microbiology, Kasturba Medical College, Light house Hill road, Mangalore-575001.Karnataka, India.
Article citation: Meghna C, BhatSevitha,Vidyalakshmi K. Risk factors and antibiotic susceptibility pattern among non-fermenting gram negative bacilli in a teaching hospital. J Pharm Biomed Sci 2014;04(08):715-718. Available at www.jpbms.info
ABSTRACT Introduction: Non‑fermenting gram negative bacilli (NFGNB) have emerged as an important health care associated pathogens especially in immune compromised patients. Characterization of NFGNB, the infections, the risk factors associated and study of their antibiogram is important in the management of infections. The aim of the present study was to characterize the NFGNB and to assess the risk factors and the antibiotic susceptibility pattern among the non fermenters. Materials and Methods: A total of 800 isolates of non fermenters from various clinical samples were identified. Antimicrobial susceptibility testing was performed by Kirby Bauer disc diffusion method. The relevant patient data were collected from the patient records. Results: Among 800 NFGNB, Pseudomonas species (59%) and Acinetobacterspecies (28%) were the prevalent pathogens. Levels of resistance to Imipenem, Meropenem were 16%, 12%for Pseudomonas spp., 43%, 62% for Acinetobacter spp. An association of Pseudomonas infection with type II diabetes was significant. Acinetobacter spp. Mostly isolated from patients with aspiration pneumonia and ventilator associated pneumonia. Conclusion: NFGNB are emerging as major nosocomial pathogens. Antibiotic susceptibility testing is necessary as carbapenem resistance is on rise.
KEYWORDS: Non fermenting gram negative bacilli; Acinetobacter; Pseudomonas; risk factors.
REFERENCES 1.In: Winn W Jr, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P, et al., editors. Nonfermenting Gram negative bacilli. In: Koneman’scolorAtlas and textbook of Diagnostic Microbiology. 6th ed. USA: Lippincott Williams and Wilkins Company; 2006.p. 305‑91. 2.Samanta P, Gautam V, Thapar R, Ray P. Emerging resistance of non‑fermenting gram negative bacilli in a tertiary care centre. Indian J PatholMicrobiol 2011; 54:666‑7. 3.Malini A, Deepa EK, Gokul BN, Prasad SR. Nonfermenting Gram-Negative Bacilli Infections in a Tertiary Care Hospital in Kolar, Karnataka. Lab Physicians. 2009, Jul-Dec; 1(2):62–66. 4.CLSI. Performance standards for Antimicrobial susceptibility testing; Twenty-Third Informational supplement. Clin Lab Stand Inst 2013; 33:66-8. 5.Aprameya IV. Non-fermenting Gram-negative bacilli (NFGNB) other than Pseudomonas .J AcadClinMicrobiol 2013;15:59-61. 6.Memish ZA, Shibl AM, Kambal AM, Ohaly YA, Ishaq A, Livermore DM.Antimicrobial resistance among non‑fermenting Gram‑negative bacteria in Saudi Arabia. J Antimicrob Chemother2012;67:1701‑5. 7.Deepak J et al. Prevalence of non fermenting gram negative bacilli and their in vitro susceptibility pattern in a tertiary care hospital of Uttarakhand: A study from foothills of Himalayas. Saudi Journal for Health Sciences. 2013 May-Aug ;Vol 2: Issue 2. 8.Samanta P, Gautam V, Thapar R, Ray P. Emerging resistance of non-fermenting gram negative bacilli in a tertiary care centre. Indian J Pathol Microbiol 2011; 54:666-7. 9.Chang TY1, Lee CH, Liu JW.Clinical characteristics and risk factors for fatality in patients with bloodstream infections caused by glucose non-fermenting gram-negative bacilli. J Microbiol Immunol Infect 2010 Jun; 43(3):233-9. 10.Upgade A, Prabhu N, Gopi V, Soundararajan N. Current status of antibiotic resistant nonfermentative gram negative bacilli among nosocomial infections. AdvApplSci Res. 2012; 3:738-42. 11.SevithaBhat, Renu Sharma, Zenith Euphemia. Carbapenem resistance in clinically significant non fermenting gram negative bacilli. Journal of Evolution of Medical and Dental Sciences. 2013; 2(47):9131-9134. 12.Gladstone P, Rajendran P, Brahmadathan KN. Incidence of carbapenem resistant nonfermenting gram negative bacilli from patients with respiratory infections in the intensive care units. Indian J Med Microbiol 2005; 23:189-91.
Competing interest / Conflict of interest The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Copyright © 2014 Meghna C,BhatSevitha ,Vidyalakshmi K.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Filename | BhatSevitha(715-718).pdf |
Filesize | 1.04 MB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 08/11/2014 01:50 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 2772 Hits |
Last updated on | 08/11/2014 02:30 |
Homepage | |
CRC Checksum | |
MD5 Checksum |