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Name | Distribution of Sickle Cell Disease in Different Communities of Patient Visiting Out Patient Department |
Description | Original article: Jayesh Warade MD1,*, Aparna Pandey2 PhD.
Affiliation:- 1Meenakshi Mission Hospital and Research Centre, Madurai, 625107 Tamilnadu, India 2Apollo Specialty Hospital, Madurai, 625107 Tamilnadu, India
The name of the department(s) and institution(s) to which the work should be attributed: Indira Gandhi Goverment Medical College,Nagpur, Maharastra,India
Address reprint requests to Dr. Jayesh Warade MD. Meenakshi Mission Hospital and Research Centre, Madurai, 625107 Tamilnadu, India
Article citation: Warade J, Pandey A. Distribution of Sickle Cell Disease in Different Communities of Patient Visiting Out Patient Department. J Pharm Biomed Sci. 2014; 04(08):728-732. Available at www.jpbms.info
ABSTRACT Background: The highest prevalence of Hb S is in tropical Africa and among blacks in the countries that participated in the slave trade. Results of studies of DNA polymorphisms linked to the ßs gene suggest that it arose from three independent mutations in tropical Africa. The sickle cell anemia and sickle cell trait are observed to occur in relatively high frequencies among the endogamous population of India. Here in this study, we have screened the sickle cell patients visiting OPD at our institution to find the cast - wise prevalence of sickle cell disease. Materials and Method: Subjects included are diagnosed cases of sickle cell disease taken from OPD. Detailed histories of every individual was obtained. Permission was taken from institutional ethical committee. Results: Most of the cases in our study are found to be from a Mahar community with decreasing frequencies in kunbi, otkar, halbi, koshti. Very few cases are also fund from teli muslim maheshwari, brhamin community. Conclusion: It is well known that sickle cell gene is widely prevalent in tribal populations. Due to recent activities of globalization, migration of population, inter-caste marriages and mixing of gene pool it has been seen that the disease which was once thought to be limited to the tribal communities is now also spreading in other communities of the society.
KEYWORDS: Sickle Cell; Tribal population; globalization; Mahar, Mutation.
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Copyright © 2014 Warade J., Pandey A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Competing interest / Conflict of interest The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
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