Property | Value |
Name | Crimean Congo Hemorrhagic Fever Virus (Cchfv) |
Description | Review article:- *Jain Hitesh 1, Gediya Shweta K.1, Thakkar Dadhichi K.1, Mansuri Nasimabanu Y.1, Ashar Komal M.2, Pasha T.Y.3 1.Sigma Institute of Pharmacy, Baroda, Gujarat, India. 2.Baroda medical College, Baroda, Gujarat, India. 3.Pioneer Pharmacy College, Baroda, Gujarat, India.
Abstract:-Crimean Congo hemorrhagic fever (CCHF) has the most extensive geographic distribution of the medically significant tick-borne viruses. Its causative agent is a negative-sense, single-stranded RNA virus belonging to the family Bunyaviridae, genus Nairovirus. The virus can be transmitted mainly through direct contact with blood or tissues from infected livestock or through bites of Hyalomma ticks. CCHF is a public health problem in many regions of the world, including Africa, Middle East, southern and Eastern Europe, and Western Asia. Crimean-Congo hemorrhagic fever (CCHF) virus causes a hemorrhagic and toxic syndrome disease in humans and high mortality rates of up to 50%. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase are raised, and bleeding markers are prolonged. Infection of the endothelium has a major pathogenic role. Besides direct infection of the endothelium, indirect damage by viral factors or virus-mediated host-derived soluble factors that cause endothelial activations and dysfunction are thought to occur. In diagnosis, enzyme-linked immunoassay and real-time reverse transcriptase polymerase chain reaction are used.
Key Words: Crimean haemorrhagic fever (CCHF), Nairovirus, Ribavirin. |
Filename | Jain Hitesh et.al..pdf |
Filesize | 221.94 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 04/17/2011 00:00 |
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Last updated on | 04/21/2011 17:17 |
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