Property | Value |
Name | Characterization of Prulifloxacin-Salicylic Acid Complex by IR, DSC and PXRD |
Description | Original research article:- *Veerendra K. Nanjwade1, F. V. Manvi1, Shamrez Ali. M2, Basavaraj K. Nanjwade1 1.Department of Pharmaceutics, KLE University College of Pharmacy, JN Medical College Campus, Belgaum – 590010, Karnataka, India. 2.Simpex Pharma Pvt. Ltd, Sigaadi, Kotdwara – 246149, Pauri Garhwal, Uttarakhand, India.
Abstract:-Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development. Objective: In this study, we aimed to characterize the of Prulifloxacin-salicylic acid cocrystals by IR, DSC and PXRD in comparision with the pure drug. Materials and Methods: Pharmaceutical cocrystals were prepared by the kneading method with aid of salicylic acid and urea as coformer. The cocrystals were subjected to various physicochemical studies and thermal methods. Results and Discussion: The cocrystal of prulifloxacin , with salisylic acid (SA) has been shown to have higher solubility than prulifloxacin. In this study, we aimed to characterize the pure drug and the cocrystals with the salicylic acid and urea. Remarkably, two new cocrystals of prulifloxacin were discovered in this study. The study indicates that the improved aqueous solubility of the cocrystals leads to improved dissolution of Prulifloxacin. Thus, the cocrystals are a viable alternative solid form that can improve the dissolution rate and bioavailability of poorly soluble drugs. Conclusion: Subsequently, differential scanning calorimetry was used to investigate the cocrystal formation. The formation of cocrystals was also verified using liquid-assisted grinding. The spectral patterns of prulifloxacin , salicylic acid and the complex were different.The physicochemical properties such as solubility and dissolution rate of this complex will be further investigated.
Key words: Pharmaceutical cocrystlas, Prulifloxacin, Salicylic acid, Complex. |
Filename | Nanjwade K Veerendra et.al..pdf |
Filesize | 417.64 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 04/17/2011 00:00 |
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Last updated on | 04/22/2011 16:36 |
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