Property | Value |
Name | Needs of Floating Drug Delivery system for Diltiazem Hydrochloride: Formulation & In-Vitro evaluation |
Description | Original research article:- 1Siddiqui Aslam Iqbal*,M.Pharm(Pharmaceutics),1Bakde Bharti Vidya,M.Pharm (Pharmaceutic), 3Dr. Kiran K Tappar (Ph.D.) 1.Pataldhamal Wadhwani College of pharmacy, SGB Amravati University, Yavatmal-445001, Maharashtra, India. 2.Vidya Bharati College of pharmacy, Amravati, Maharashtra, India.
Abstract:-The present research work aimed to design a gastro retentive floating drug delivery system for sustained release of Diltiazem Hydrochloride. Diltiazem HCl has site specific drug absorption from upper part of gastrointestinal tract and it is insoluble at higher pH (i.e. lower part of GI tract), therefore poorly absorbed from lower part of GI tract. Unabsorbed drug causes impaired therapeutic effect, increases frequency of dose administration and contributes to more side effects. Therefore a gastro retentive dosage form is required to ensure the controlled drug delivery of Diltiazem HCl within a drug absorbable region. Various grades of low density polymers (HPMC K4M, HPMC K15M, HPMC K100M and Xanthan gum) were used for formulation of this system. They were prepared by physical blending of Diltiazem HCl, polymers and effervescent agent in varying ratios. The formulation was optimized on the basis of In vitro bouncy and In vitro release in 0.1 N HCL buffer solutions. In vitro buoyancy was found to be in the range of 10 to 25 seconds and percent swelling index in the range of 130 to 332 %. Floating time was more than 12 hrs. In vitro drug release of the optimized batch (F5) was found to be 94.15 % at the end of 12th hr and it show the best fit model as matrix and it shows non-fickian type of drug release. The floating tablets were also evaluated for uniformity of weight, hardness, friability, drug content and effect of hardness on floating lag time.
Keywords: Effect of Hardness on Floating Lag Time and Total, Floating time, In vitro, Buoyancy studies, Mechanism of release, Water uptake study. |
Filename | Siddiqui et.al..pdf |
Filesize | 270.8 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 04/18/2011 00:00 |
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Last updated on | 04/26/2011 16:00 |
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