Property | Value |
Name | Ameliorative Effects of Hibiscus Sabdariffa Extract Against Carbon tetrachloride-Induced Lipid Peroxidation, Oxidative Stress and Hepatic Damage in Rats |
Description | Original article
Famurewa Ademola C1,*, Kanu Shedrach C1, Uzoegwu Peter N2, Ogugua Victor N2
Affiliation: 1Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria, PMB 1010 Abakaliki, Nigeria
2Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed: 1.Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria, PMB 1010 Abakaliki, Nigeria
2.Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria
Address reprint requests to * Famurewa, Ademola Clement. Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo, Ebonyi State
Article citation: Famurewa, A.C., Kanu, S.C., Uzoegwu, P.N., Ogugua, V.N. Ameliorative effects of hibiscus sabdariffa extract against carbon tetrachloride-induced lipid peroxidation, oxidative stress and hepatic damage in rats. J Pharm Biomed Sci. 2015;05(09):725-732. Available at www.jpbms.info
ABSTRACT: Objective: Hibiscus sabdariffais a medicinal plant associated with beneficial health effects. The leaves and flowers are used as traditional drinks and medicines in countries. The current study aimed to investigate Hibiscus sabdariffa Linn methanolic extract ameliorative potential against carbon tetrachloride-induced lipid peroxidation, hepatic damage and oxidative stress. Methods: Adult male Wistar rats were administered 2.5ml/kg body weight of CCl4 by oral gavage to induce oxidative stress 48 hours before administration of 200, 600 to 1000mg/kg doses of Hibiscus sabdariffa methanolic extract to group 3, 4 and 5, respectively for 10 days (n=5). Group 1 was used as negative control, while group 2 was used as positive-comparative control (2.5ml/kg CCl4). At the end of the experiment, serum glutathione (GSH), vitamin C and E, MDA, liver damage markers and antioxidant enzymes were analysed in all the groups. Results: Carbon tetrachloride-induced oxidative stress in experimental rats was evidenced by increase in malondialdehyde (MDA) and reduction in SOD, catalase and reduced glutathione (GSH).Hibiscus sabdariffa extract treatment at 600 and 1000mg/kg doses resulted in significant modulation of antioxidant indices and alkaline phosphatase (p<0.05), but failed to demonstrate significant effects in AST, ALT and MDA. There were significant increases (p<0.05) in the serum vitamin C and E at 600 and 1000mg/kg doses of the extract. Conclusion: The overall results suggest that hibiscus sabdariffa contains bioactive phytochemicals that may improve hepatic status and ameliorate oxidative damage at high doses in carbon tetrachloride intoxication.
KEYWORDS: Hibiscus sabdariffa; hepatic damage; lipid peroxidation; oxidative stress; phytochemicals.
REFERENCES
Source of funding: None |
Filename | Famurewa AC(725-732).pdf |
Filesize | 298.89 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 09/16/2015 00:00 |
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Maintained by | Editor |
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Last updated on | 09/30/2015 09:06 |
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