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Name | A Validated UV Spectrophotometric Method for the Simultaneous Estimation of Amlodipine Besylate, Valsartan and Hydrochlorothiazide in Bulk and in Combined Tablet Dosage Form |
Description | Original research article:- *Jothieswari. D1,2 , Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4,Stephen Rathinaraj. B5 1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India. 2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India. 3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India. 4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India. 5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water. This method involves the formation and solving of simultaneous equations at 239 nm, 250 nm and 272 nm, as absorbance maxima of amlodipine besylate, valsartan and hydrochlorothiazide, respectively. Beer’s law obeyed the concentration range of 1 – 32 mcg/ mL, 4 – 40 mcg/ mL and 2 – 20 mcg/ mL for amlodipine besylate, valsartan and hydrochlorothiazide, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the simultaneous estimation of these three drugs in bulk and in combined tablet dosage form.
Keywords:- Amlodipine Besylate, Valsartan, Hydrochlorothiazide, Simultaneous equation method, Method validation. |
Filename | D Jothiewari et. al..(UV).pdf |
Filesize | 210.77 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 04/17/2011 00:00 |
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Last updated on | 04/26/2011 16:57 |
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