Property | Value |
Name | Hepatoprotection: Role of Herbal Antioxidants |
Description | Review article:- *Preeti singh1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal1 Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:-Liver toxicity is caused by different compounds in which oxidants or free radicals plays a major role. They are very hazardous to our body by damaging the proteins, DNA, RNA and lipids, due to of this virtue. They can cause very severe diseases like Neurodegeneration, Hepatotoxicity, Aging, Cancer, Cardiovascular disease, Immune system decline and Cataract. To avoid these problems, antioxidants used, which act as free radical scavengers. Antioxidants are present naturally; endogenously (superoxide dismutase, H2O2-removing enzymes and metal binding proteins) yet they are not sufficient to prevent damaging at the oxidative stage, but dietary antioxidants (vitamin A, E, C, carotenoids and plant phenol like flavonoids) as a special nutrient. Lipid peroxidation is the major cause of hepatotoxicity caused by oxidative stress. The primary induction of hepatotoxicity is inducing level of liver enzymes as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Gamma-glutamyltransferase (GGT). Most of the mechanism of antioxidants is to decrease the elevated level of the enzymes in serum via different mechanism and in case of liver toxicity eventually to stops the lipid peroxidation. In this scenario extract of plants like Silymarin; Terminalia catappa L; Byrsocarpus coccineus and more species of plants, and their secondary metabolites are proved to be impressive useful as hepatoprotectives.
Key Words: Antioxidants; Hepatoprotectives; Free radicals; ROS; Lipid peroxidation; Oxidative stress. |
Filename | Singh Preeti et. al..pdf |
Filesize | 277.13 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 04/17/2011 00:00 |
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Maintained by | Editor |
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Last updated on | 04/28/2011 02:27 |
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