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Name | A simple and fast comparative procedure for one-pot synthesis of antifungal active 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines. |
Description | Original research article:- Monika Gupta* Department of Chemistry, University of Jammu, Jammu-180 006, India.
Abstract:-A simple and fast procedure is developed for the one-pot synthesis of novel 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines from 5-aryl-3,4-diamino-1,2,4-triazoles and acetophenone or substituted acetophenones in the presence of catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium as well as homogenizer using microwave irradiation as well as by stirring at 800C in a pre-heated oil-bath. Comparative method is simple, fast and economic and gives moderate to good yields of products and are in a state of high purity. Some of these compounds are evaluated for antifungal activity.
Keywords:-Acetophenones, triazoles, triazepines, triazolo-triazepines, N,N-dimethylformamide, p-TsOH, microwave activation. |
Filename | Gupta Monika.pdf |
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Created On: | 04/18/2011 00:00 |
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Last updated on | 04/28/2011 03:17 |
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