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Name | Ethanolic extract of cashew leaves restores hepatic and renal integrity in streptozotocin-induced diabetic rats. |
Description | Original research article:- *Egwim, Evans. C1 , Oloyede, O. B1 1.Department of Biochemistry, University of Ilorin, PMB 1515, Kwara State, Nigeria.
Abstract:-The effect of ethanolic extract of cashew leaves on hepatic and renal integrity was investigated in male streptozotocin-induced diabetic. Organ/ body weight ratio, total lipids and cholesterol levels were monitored in the liver and kidney. GOT and GPT activities were assayed in the liver. Histological studies were carried out in the kidney. The result showed that the proportion of liver and kidney to body weight in the treated rats were restored to normal compared to the control rats while those of the diabetic rats were higher. Total lipid and cholesterol levels in the liver were significantly (ρ < 0.05) reduced in the treated rats (239 ± 9 and 47.5 ± 1.3mg/g respectively) and were comparable to the control values (216 ± 2.0 and 34.0 ± 1.5mg/g respectively). Total lipid levels were significantly (ρ < 0.05) higher in the kidney of the treated rats (148.0 ± 1.75mg/g) and control rats (149.0 ± 0.50mg/g) than in the kidney of the diseased rats (136.5 ± 1.75mg/g). The GPT/GOT ratios in the liver of the treated rats (0.7) were comparable to that of the control (0.8) while that of the diabetic rats remains high (1.0). It is concluded that Ethanolic extract of cashew leaves is able to restore some of the biochemical abnormalities associated with diabetic liver and kidney.
Key Words:-Restoration, hepatic, renal, diabetics, integrity, and cashew leave. |
Filename | Evan Egwin et.al..pdf |
Filesize | 207.09 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 05/16/2011 00:00 |
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Last updated on | 05/30/2011 16:38 |
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