Property | Value |
Name | Microwave Assisted and Conventional Synthesis, Characterization and Biological Activity of 2-Azetidinones and 4-Thiazolidinones |
Description | Original research article:- *Omprakash G. Bhusnure1, Sham S. Mokale2, Yogesh S.Nalwar2, Yeshwant B.Vibhute2 1.Dept. of Pharmaceutical Chemistry,Maharashtra College of Pharmacy,Nilanga, Dist.Latur, India. 2.P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India.
Abstract:- A series of 2-azetidinones and 4-thiazolidinones of 4,4'-sulfonyldianiline have been synthesized under microwave irradiation and conventional heating, 4,4'-sulfonyldianiline was condensed with hydroxy halogeno substituted aromatic aldehyde in Methanol/DMF in the presence of 1-2 drops of conc. HCl as a catalyst under conventional heating and microwave irradiation to yield the Schiff base respectively (1a-d). The Schiff’s bases (1a-d) on treatment with chloroacetyl chloride in the presence of triethylamine gave 2-azetidinone (2a-d). Cyclocondensation of Schiff's bases with 2-mercaptosuccinic acid afforded 4-thiazolidinone derivatives (3a-d). The microwave assisted reaction was remarkably successful in higher yield at less reaction time compared to conventional heating method. Spectral data (IR, NMR and Mass spectra) confirmed the structures of the synthesized compounds. All the synthesized products are screened for their in vitro antibacterial, antifungal and anti-tubercular activity. The results indicated that the synthesized compounds have moderate to potent activities at low and high concentration with reference to their appropriate reference standards. Key words:- 2-Azetidinone, 4-thiazolidinone, Microwave method, Antibacterial, Antifungal and Anti-tubercular activity. |
Filename | Bhusnure G Omprakash et. al..pdf |
Filesize | 203.98 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | |
Created On: | 05/17/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 10648 Hits |
Last updated on | 05/31/2011 18:26 |
Homepage | |
CRC Checksum | |
MD5 Checksum |