Property | Value |
Name | Use of Hydrophobic Fumed Silica and Selected Binders in the Tablet Formulation of a Deliquescent Crude Plant extract: Vernonia galamensis (Asteraceae) |
Description | Original research article:- *,Autamashih Musa (M. Sc) 1 Isah Adamu B (Ph. D)1, Allagh Teriyila S (Ph. D)1, Ibrahim Musa A (Ph. D, Professor)2 1.Department of Pharmaceutics and Pharm. Micro., Faculty of Pharm. Sciences, Ahmadu Bello University, Zaria, Nigeria. 2.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharm. Sciences, University of Jos,Nigeria.
Abstract Context:- Leaves of Vernonia galamensis have been used for ages in folk medicine for the treatment of diabetes mellitus. The crude leaves extract is highly hygroscopic and deliquescent and efforts to use the common diluents; lactose, maize starch and magnesium carbonate for tablet formulation was futile as very poor quality tablets with many defects especially ‘sticking’ and ‘picking’ were produced. To counteract this deliquescent property, an efflorescent diluent; hydrophobic fumed silica, was carefully selected for the formulation. Aim: To investigate the effect of hydrophobic fumed silica in the tablet formulation of the deliquescent crude extract of Vernonia galamensis using selected standard binders. Materials and Methods: Materials included; hydrophobic fumed silica (Aerosil® R9200, Evonic Industries AR, Germany), maize starch and gelatin (May and Baker, Germany). Granule and tablet analyses were carried out according to standard procedures in the BP 2007. The mechanical strengths of tablets were assessed using the crushing strength-friability, disintegration time ratio (CSFR:DT) and the drug release properties using dissolution times. Statistical analysis: GraphPad Prism® version 5.03 software was used. Results and conclusions: An increase in binder concentration led to an increase in crushing strength, decrease in friability and increase in disintegration time of the tablets. Fumed silica used as diluent along with gelatin as binder produced the best quality tablets in terms of the CSFR:DT ratio and dissolution rate.
Key words:- Diabetes mellitus, Fumed silica, Vernonia galamensis. |
Filename | Autamashih et.al.pdf |
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Created On: | 05/17/2011 00:00 |
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Last updated on | 06/07/2011 04:37 |
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