Property | Value |
Name | Involvement of nNOS in the antidepressant-like effect of Withaferin-A in rats |
Description | Original Research article:- * Zaved Ahmed Khan1, Asit Ranjan Ghosh2 1,2 Medical Biotechnology Division,School of Biosciences and Technology, VIT University,Vellore-632014,TN, India.
Abstract:- The involvement of nitrergic mechanisms in the behavioural effects of withaferin A in rats was studied in the forced swim test. Administration of the withaferin A (10 mg/kg, i.p.), assumed to increase the synthesis of NO , if given with subeffective dose of L-NAME (10 mg/kg , i.p) Neither withaferin A alone nor L-NAME affected the immobilized time of animals in the forced swim test. We conclude that a suppression of NO synthase activity may be important in the anti-depressant effect of Withaferin-A.
Key words:- Withaferin-A, L-NAME, Nitric Oxide,Anxiety,Forced Swim Test and Nnos. |
Filename | Khan Ahmed Zaved et.al..pdf |
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Created On: | 06/16/2011 00:00 |
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Last updated on | 07/06/2011 05:34 |
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