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Name | Spectrophotometric determination of the active components of a ternary mixture containing Chlorpheniramine maleate, Diclofenac sodium and Paracetamol |
Description | Original research article:- *Ekram M. Hassan1, Mohamed S. Mahrous2 and Ruba N.Shdeed1 1Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry and Quality Control , Beirut Arab University, Riad El Solh 11072809 P.O. Box 115020Beirut, Lebanon. 2Faculty of Pharmacy, Department of Pharmaceutical Chemistry , Beirut Arab University, Riad El Solh 11072809 P.O. Box 115020,Beirut, Lebanon.
Abstract:- Two spectrophotometric methods are presented for the determination of a ternary mixture containing chlorpheniramine maleate, diclofenac sodium and paracetamol in combined dosage form without prior separation. The first method is the derivative ratio spectra zero crossing method (DRSZ) where chlorpheniramine maleate, diclofenac sodium were determined by measuring the DD1 amplitudes at 246.7nm, 290.2 nm and paracetamol was determined by measuring the DD1 , DD2 and DD3 amplitudes at 252.8nm, 246.3 nm and 254.3 nm , respectively. The second method is the double divisor ratio spectra derivative method (DDRD) where diclofenac sodium was determined by measuring the DD1 , DD2 at 311 nm and 307 nm, respectively and paracetamol was determined by measuring the DD1 , DD2 and DD3 amplitudes at 253.7nm, 247.9 nm and 253.8nm , respectively. The methods were linear over the concentration range 20-100 μgml-1 chlorpheniramine maleate, 5-40 μgml-1 diclofenac sodium and 2-18 μgml-1 paracetamol. The described methods are rapid , accurate, simple and precise and can be used for quality control of such mixture.
Key words:-Chlorpheniramine maleate, diclofenac sodium, paracetamol , ternary mixture , derivative ratio, double divisor derivative ratio. |
Filename | Hassan M Ekram et.al..pdf |
Filesize | 301.39 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 06/16/2011 00:00 |
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Last updated on | 07/06/2011 06:46 |
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