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Name | Study of lipid profile in Hypertensive patients in rural Karnataka |
Description | Research article:- Dr.Pramiladevi.R. MD1 , Dr. Gooranavar. S.M. MD2, Dr. Biradar.Satish.B. MD3 , Dr. Baragundi .Mahesh.C. MD4 , Dr. Kora .S.A. MD5, Dr.Narayan.M MS. 6 1.Associate Professor in Dept. of Medicine, S.Nijalingappa Medical College Bagalkot-587102 Karnataka India. 2.Asst- Professor in Dept. of Medicine, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India. 3.Asst- Professor in Dept. of Medicine, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India. 4 Associate Professor in Dept. of Microbiology, S.Nijalingappa Medical ,College Bagalkot-587102 Karnataka India. 5.Associate Professor in Dept. of Medicine, S.Nijalingappa Medical ,College Bagalkot-587102 Karnataka India. 6.Senior Resident in Dept. of Surgery, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India.
Abstract: Context: Dyslipidemia and hypertension are the commonest risk factors for coronary artery disease (CAD). Persons with combination of risk factors are particularly at high risk of CAD. There is also pronounced influence of blood pressure on the rate of atheroma formation in human subjects. Isolated systolic hypertension commonly seen in elderly subjects can be attributed to atherosclerosis induced stiffening of aorta and major arteries. Aim: This study was therefore carried out 1.To know abnormal lipid profile prevalence and pattern among hypertensive patients and 2.To know association between hypertension and dyslipidemia in our population. Materials and Methods: The present study was carried out on a total of 50 hypertensive patients attending our tertiary care Hospital and 50 age and sex matched healthy controls. Twelve hour fasting lipid analysis was done for Serum triglycerides(TG), total cholesterol(TC), HDL, LDL, VLDL, TC/HDL, Lp(a)&CLTI. Lipid fractions were tabulated according to NCEP/ATP III new guide lines. Statistical analysis was done by t test, Z test and Chi square test. Results and conclusions: Over all mean lipid levels of TC, LDL, Lp(a), TC/HDL >4.5, showed statistically significant association with cases compared to controls. No significant association was noticed in HDL levels between cases and controls. Mean lipid levels with respect to sex, showed abnormalities in TC, Lp(a) and TC/HDL, CLTI more in hypertensive males compared to females as well as controls. Elevation of TC and decrease in HDL was found as the severity of hypertension increased. The commonest individual lipid fraction abnormality was low HDL in 74% followed by elevated total cholesterol in 52%. Next commonest being TC/HDL >4.5 in 50%, followed by elevated Lp(a) in 36%. Commonest lipid abnormality was abnormal TC/HDL>4.5& elevated TG together in 86%. Over all prevalence of all forms of dyslipidaemia was 90% Key Messages:1.Elevated TC, LDL, Lp(a), TC/HDL >4.5, are significantly associated with hypertension and we must consider primary and secondary prevention with life style modification and drug therapy in hypertensive patients.2.There is no significant association between HDL levels and hypertension.3.Commonest lipid abnormality is abnormal TC/HDL& elevated TG together in 86% and over all prevalence of all forms of dyslipidaemia is 90% (too high). 4.Abnormalities in lipid profile antedate the occurrence of stage I hypertension, therefore it is advisable to recommend lipid profile as screening of asymptomatic prehypertensive patients.
Key words: -Hypertension, Dyslipidaemia, HDL, LDL, VLDL, TC/HDL, Lp (a), CLTI.
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Created On: | 06/16/2011 00:00 |
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