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Name | Quantitative variation of Erythrocyte Catalase and Glutathione Peroxidase levels in Leukemias |
Description | Original research article:- K. N. Pujari1, S. P. Jadkar1, Aruna Kulkarni2, C. G. Patil1, V. B. Tuljapurkar3 1.Assistant professor, Department of Biochemistry, Govt. Medical College, Miraj, India. 1Ph.D. student, Department of Biochemistry, Govt. Medical College, Miraj, India. 1.Lecturer in Statistics and Demography,Govt. Medical College, Miraj,India. 2.Ex Professor, Grant Medical College, Mumbai, Maharashtra,India. 3.Senior medical oncologist, Department of Medical Oncology, Shri Shiddhivinayak Ganapati Cancer Hospital, Miraj,India.
Abstract:-Catalase and glutathione peroxidase are the antioxidant enzymes produced naturally within the body. These help the body to convert hydrogen peroxide into water and oxygen, thus preventing the formation of carbon dioxide bubbles in the blood. The enzyme levels of catalase and glutathione peroxidase are altered to considerable extent in various diseased states exhibiting either elevation or depletion in their activity, this phenomenon was found to be more evident in leukemias. We have determined the catalase and glutathione peroxidase activity in the erythrocytes of leukemic patients and these levels were significantly low as compared to control. In respect to sex, the mean catalase levels in males (5.750 ± 0.310) were found to more than that in females (5.671 ± 0.301) however, this difference is non-significant. Whereas in respect to age, the mean catalase levels in age >11 years are decreased suddenly in AML patients (7.375± 0.050 to 5.730± 0.362). In case of glutathione peroxidase, we cannot found any change with respect to sex. However in age group <10 years and 11-20 years there is a sudden increase in mean glutathione peroxidase levels in AML patients (32.41 ± 0.635 to 33.28 ± 0..754). We found significant trend in catalase and GPx levels with respect to age in ALL only. We observed highly significant (p<0.001) catalase and glutathione peroxidase dismutase levels in acute leukemias with respect to age. Our results suggest that oxidative stress in leukemia patients causes the deficiency in antioxidant enzyme, which arise as a result of enormous production of reactive oxygen species in the system.
Key Words:-Leukemia,Catalase, Glutathione peroxidase, Hydrogen peroxide. |
Filename | Pujari K N et.al..pdf |
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Created On: | 06/16/2011 00:00 |
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Last updated on | 07/22/2011 12:59 |
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