Property | Value |
Name | Formulation and Evaluation of Semisolid preparation (Ointment, Gel & Cream) of Thiocolchicoside |
Description | Original Research article:- *Jadhav Ravindra T1, Patil Pratibha R.2, Patil Payal H2
1.M.J.Biopharm Pvt. Ltd., L-7, M.I.D.C. indl. Area, Taloja, Raigad District, Maharashtra., India. 2.Department of Quality Assurance & Pharmaceutics,R.C.Patel Institute of Pharmaceutical Education & Research,Shirpur- 425405, Dhule District, Maharashtra., India.
Abstract:-The aim of present work was to develop a semisolid preparation (ointment, gel, cream) of Thiocolchicoside which is a cen-trally acting skeletal muscle relaxant for the effective treatment of muscle spasm. Thiocolchicoside has been claimed to posses GABA mimetic & glycinergic actions in other way can say that Thiocolchicoside is a gama-aminobutyric receptor agonist. It has recently been shown that thiocolchiocoside activity can be ascribed to its ability of interacting with strychnine sensitive glycine receptors & therefore that compounds endowed with the glycino-mimetic activity can be used in rheumatologic-orthopedic field for their muscle relaxant properties. It is widely prescribed for treatment of muscle spasm, cramps, musculoskeletal & neuromuscular disorder. Thiocolchicoside is available in market in the form of capsules & Injection. The major problem associated with Thiocolchicoside is its bioavailability which is very low i.e. 25% only so in order to minimize drug loss due to first pass metabolism, and overcome problem associated with low bioavailability drug there is need to formulate semisolid preparation . The aim of the study was to formulate & evaluate thiocolchicoside ointment, gel & cream and comparative study of their drug release. In vitro release of thiocolchicoside from the three bases i.e., ointment, gel, cream to an aqueous receptor phase through whatman filter paper no.41 as well as mice skin was monitored spectrophotometrically at a wavelength of 259nm. In vitro release study results showed that the steady state fluxes of the drug from vehicles rank according to the following order: ointment >gel >cream. Ointment base showed considerably higher drug release than other vehicles.
Key words :- Thiocolchicoside, ointment, gel, cream, diffusion. |
Filename | Jadhav Ravindra T et.al..pdf |
Filesize | 190.25 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 07/17/2011 00:00 |
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Last updated on | 08/10/2011 16:33 |
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