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Name | Stress Degradation Studies on Valsartan and Development of a Validated Method by UV Spectrophotometric in Bulk and Pharmaceutical Dosage Form |
Description | Original research article:- *Pradhan Kishanta Kumar1, Mishra Uma Shankar1, Pattnaik Subasini2, Panigrahi Ghanshyam1, Pasa Gourishyam1, Sahu Kanhu Charana1.
1.Department of Pharmaceutical Analysis and Quality Assurance, Royal college of Pharmacy and Health Sciences, Andhapasara Road, Berhampur, Odisha, India. 2.Department of Zoology, Berhampur University, Bhanja Bihar, Berhampur, India.
Abstract:- A simple method for the estimation for the estimation of Valsartan in bulk and pharmaceutical dosage forms has been developed. Methanol was chosen as the solvent system.The λmax was found to be 249nm and all absorbance values were carried out at 249nm.The responses were linear in the range of 5-100µg/ml.The regression equation of the calibration graph and correlation coefficient were found to be y = 0.028x - 0.001 and 0.999 respectively. The %RSD values for both intraday and interday precision were less than 1%. The recovery of the drug from the sample was ranged between 97.77% and 101.4%. The proposed method was validated for accuracy, precision, robustness, ruggedness,LOD and LOQ.Commercial tablets containing 40mg and 80mg of valsartan were analysed by the proposed method and the results were well within the claimed limits.Furthermore stability studies of Valsartan were carried out under acidic, alkaline, hydrolytic, thermolytic, oxidation, photolytic and UV degradation conitions as per SIAM (Stability Indicating Assay Methods).
Key Words:- Analytical method validation, Beer’s law, Forced degradation, UV- spectrophotometry, Valsartan. |
Filename | Pradhan Kumar K et. al..pdf |
Filesize | 512.59 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 07/17/2011 00:00 |
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Last updated on | 08/10/2011 18:02 |
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