Property | Value |
Name | Glibenclamide alters some biochemical laboratory parameters |
Description | Original research article:- Ibrahim IA 1, *Al-Joudi FS 2, Waleed Sulaiman R 3,Hammoudi N 3 and Al-Saffar R 4 1.Department of Pharmacology, Faculty of Medicine, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia. 2.Department of Microbiology, Royal College of Medicine Perak, University of Kuala Lumpur, Ipoh, Malaysia. 3.Department of Clinical Laboratory Science, College of Pharmacy, Baghdad University, Baghdad, Iraq. 4.Department of Medicine, Hospital Dr. Abdul-Majeed, Karrada, Baghdad, Iraq.
Abstract:- Glibenclamide is a second-generation sulfonylurea oral hypoglycemic agent. The effects of glibenclamide on some biochemical laboratory findings were monitored both in-vitro and in-vivo. For this study, 40 subjects had been newly diagnosed with NIDDM, with an age range of 40 to 70 years, and 30 apparently healthy volunteers of comparable ages were recruited as the control group. In-vitro and in-vivo tests were performed. In the in-vitro tests, solutions of different drug concentrations were prepared according to their maximum serum concentrations and were added to blank, control, and serum samples. In the in-vivo study, venous blood samples were collected from each subject before the start of drug therapy and two weeks after the start of treatment. The samples were analyzed for glucose, total protein (TP), urea, creatinine, total cholesterol (TC), triglyceride (TG), aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) and creatine kinase (CK). In the in-vitro study, the glibenclamide caused a reduction in the readings of the serum levels of glucose, urea, TC and TG, whereas the read concentrations of TP and creatinine were raised. The concentrations of all the enzymes tested were decreased by glibenclamide. In the in-vivo study, the concentrations of serum glucose, TP, creatinine, TG, AST, ALT and LDH were decreased. However, no change was induced in urea level. Glibenclamide induced some alterations in the biochemical parameters. These changes may have been the result of chemical or physical interactions, possibly enhanced by physiological or metabolic factors especially those detected in in-vivo tests.
Key Words:- Glibenclamide, chemical or physical interactions, physiological or metabolic factors, biochemical tests. |
Filename | F S Al-Joudi et.al..pdf |
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Created On: | 07/16/2011 00:00 |
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Last updated on | 08/10/2011 18:45 |
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