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Name | Development of Nimodipine Fast Dissolving Tablets: Effect of Functionality of Hydrophilic Carriers on Solid Dispersion Technique |
Description | Original research article:- N. G. Raghavendra Rao*, M. Subhan
PG. Department of Pharmaceutics, Luqman College of Pharmacy Gulbarga- 585 102. Karnataka, India.
Abstract:- An attempt has been made for the development of fast dissolving tablets of the nimodipine by solid dispersion methods, using different concentrations of croscarmellose sodium as super disintegrating agent and study the effect of various carriers on solid dispersion technique. Nimodipine is used in the treatment of various cardiovascular disorders such as angina pectoris, cardiac arrhythmia and hypertension. The major problem of this drug is very low solubility in biological fluids and poor bioavailability after oral administration. The prepared tablets were evaluated for post-compressional parameters like hardness, friability, drug content, disintegrating time, wetting time, In-vitro dissolution studies and stability studies. The prepared tablets were characterized by DSC and FTIR Studies. No chemical interaction between drug and excipients was confirmed by DSC and IR studies. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The formulations prepared with mannitol solid dispersion were showed disintegration time between the ranges of 15.12 - 21.92 sec and drug release showed between the ranges of 09 - 11 min. However the formulations prepared with PEG‐6000 and PVP solid dispersions did not disintegrate in specified limit of time for fast dissolving tablet. Among all formulations SM4 prepared with mannitol as carrier showed 99.63 % drug release within 9 minutes. The results concluded that fast dissolving tablets of poorly soluble drug, Nimodipine showing enhanced dissolution will lead to improved bioavailability, improved effectiveness and hence better patient compliance. Finally it is concluded that effect of mannitol as a carrier on solid dispersion technique is excellent and shows best result.
Keywords:- Fast dissolving tablets, Nimodipine, croscarmellose sodium, Solid dispersion. |
Filename | Rao Raghavendra N G et. al..pdf |
Filesize | 513.29 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 07/17/2011 00:00 |
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Last updated on | 08/13/2011 09:01 |
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