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Name | The Biochemical Changes in Rats Following Chronic Toxicity with Cassia Singueana Leaf Extract |
Description | Original research article:- *Ode, Okwoche J.1, Asuzu, Onyeka.V.2 , Oladele Gbenga. M.1 1.Ph.D, Department of Veterinary Pharmacology and Toxicology, University of Abuja, PMB 117 Abuja, Nigeria. 2.DVM, Department of Veterinary Pharmacology and Physiology, University of Nigeria, Nsukka (UNN).
Abstract:- Evaluation of the biochemical changes in rats following chronic toxicity with Cassia singueana leaf extract was carried out. The extract was prepared by cold maceration using 80% methanol. The total solids recovered from extracts were 11.7 percent (w/w). Four groups (A-D) made up of 12 albino wistar rats per group were subjected to chronic exposure to varying concentrations of the extract. Serum biochemical analysis was carried out on the separate rat groups on days 28, 56 and 84. The data generated were analyzed using one-way ANOVA. Mean differences were considered at P=0.05. The results revealed that there were no significant (p<0.05) changes between the serum values of AST, ALT and ALP of normal rats and the test rats that received the long-term exposure to varying doses of the extract in feed. C. singueana extract induced significant (P=0.05) dose-dependent increases in total proteins of rats that had exposure to the extract compared with values in control rats. The doses, 0.5 g and 1.0 g extract/kg feed induced significant (P=0.05) increases in the mean total cholesterol values of test rats compared to control from days 56 to 84. All doses (0.25, 0.5 and 1.0 g/kg feed) of C. singueana extract caused significant (P=0.05) reduction in malondialdehyde (MDA) value of test rats relative control from the onset of the study up to day 56. The serum biochemical changes were generally within normal ranges, the use of the extract for therapeutic medication may not therefore be a health hazard.
Keywords:- Aminotransferase, Cassia singueana, Cholesterol, Biochemical analysis, Malondialdehyde. |
Filename | Ode Okwoche J et al. -1.pdf |
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Created On: | 07/17/2011 00:00 |
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Last updated on | 08/13/2011 18:46 |
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