Property | Value |
Name | Effect of Foeniculum vulgare Mill. Fruits in Obesity and Associated Cardiovascular Disorders Demonstrated in High Fat Diet Fed Albino Rats |
Description | Original research article:- 1 Dr. Chanchal Garg, 2 Prof. S. H. Ansari, 2 Prof. S. A. Khan, 3Dr. Munish Garg. 1.Vaish Institute of Pharmaceutical Education and Research, Rohtak-124001, Haryana, India 2.Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. 3.Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India.
Abstract:- Present work is based on screening of Foeniculum vulgare Mill. Fruit extracts in high fat diet fed albino rats for their possible role in obesity and associated cardiovascular disorders. Three fractions prepared by successive solvent technique from methanol extract of Foeniculum vulgare Mill. fruits were administered at a dose of 300 mg/body weight by oral gavage and volatile oil obtained by hydrodistillation at a dose of 0.2 ml/body weight intraperitoneally once daily along with high fat diet to the female albino rats for six weeks (0-42 days). Normal control and high fat diet fed control groups were maintained simultaneously. Body weight of the experimental animals was estimated every week while lipid parameters and fat pad weights were estimated after 42 days after sacrificing the animals by euthanasia. Phytochemical studies were carried out of the above mentioned extracts. Results revealed that body weight and fat pad weights were reduced in drug fed animals in a variable pattern. Cholesterol and triglycerides levels, which were disturbed in high fat diet fed animals, improved in a significant manner. Maximum activity was observed with methanol fraction of the drug which contained maximum amount of phenolic (48.37 mg/g) and flavonoidal contents (21.44 mg/g). Based on the scientific reports, that antioxidant compounds play a vital role in the management and control of obesity via improvement in natural antioxidant defense and lipid metabolism, it is predicted that the observed activity may be due to this or more of these mechanisms. In conclusion, Foeniculum vulgare, a well known herb in Indian system of medicines has demonstrated to be effective in obesity and associated cardiovascular disorders.
Key words:- Foeniculum vulgare, obesity, cardiovascular disorders, hyperlipidemia. |
Filename | Garg Chanchal et.al..pdf |
Filesize | 237.16 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 07/17/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 6828 Hits |
Last updated on | 08/20/2011 17:32 |
Homepage | |
CRC Checksum | |
MD5 Checksum |