Property | Value |
Name | NECROLYTIC MIGRATORY ERYTHEMA ASSOCIATED WITH GLUCAGONOMA SYNDROME - A REVIEW ARTICLE |
Description | Review article:- Piplani S1, * Lalit M2, Arora AK3.
1.Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab,India. 2.Chintpurni Medical College,Bungal, Pathankot, Punjab, India. 3.Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.
Abstract-: Glucagonomas an uncommon clinicopathological entity originate from the alpha-2 cells of the pancreas The syndrome goes by the acronym 4D syndrome, which stands for dermatosis, diarrohea, deep vein thrombosis and depression. Necrolytic migratory erythema (NME) is the most characteristic clinical sign of this pathology. It is associated with hyperglucagonemia, diabetes mellitus, hypoaminoacidemia, cheilosis, normochromic, normocytic anemia, and weight loss. NME features a characteristic skin eruption of red patches with irregular borders, intact and ruptured vesicles, and crust formation.The tumor cells are occasionally organized in nests and strands and appear strongly glucagon-positive on immunohistochemical staining. The correct recognition of NME is very important, because it may allow early detection either of glucagonoma or of extrapancreatic, glucagon-secreting tumors. Glucagonoma is a slow growing tumor and good recovery is possible after surgical resection.
Key words:- Glucagonoma, Hyperglucagonemia, Necrolytic migratory erythema (NME), Diabetes mellitus. |
Filename | Piplani S et.al..pdf |
Filesize | 185.88 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 08/16/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
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Last updated on | 09/04/2011 16:22 |
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