Property | Value |
Name | Community acquired MRSA and its susceptibility patterns in a tertiary care |
Description | Research article:- * Dr Anila.A.Mathews MD 1 , Dr Marina Thomas MD.2, Dr B.Appalaraju MD2. 1. Assistant professor, Dept of microbiology, PSGIMSR,Coimbatore, India. 2.Professor of Microbiology, Dept of microbiology ,PSGIMSR, Coimbatore, India. 3.Professor and Head , Dept of microbiology, PSGIMSR,Coimbatore, India.
Abstract:- Background and Objectives: Traditionally, methicillin resistant Staphylococcus aureus (MRSA) is considered as a nosocomial pathogen, but an increasing prevalence of community acquired MRSA is being reported worldwide including India. This study is aimed at identifying the prevalence and susceptibility characteristics of community acquired MRSA in our hospital. Materials and methods: The study group consisted of 208 consecutive MRSA identified on the basis of their resistance to cefoxitin disk (30 µg) by the disc diffusion method and mecA gene detection by polymerase chain reaction (PCR). Isolates were categorized as community acquired MRSA based on criteria for inclusion and their antibiotic susceptibility was compared with that of the hospital acquired MRSA isolates. Results: Among the 208 MRSA analyzed, 18 % (n=37) were community acquired . The isolates were significantly more sensitive to ciprofloxacin than the hospital acquired MRSA isolates. Discussion: The prevalence of community acquired MRSA in this study (12%) is comparable to its prevalence in other studies across India. Susceptibility to antibiotics other than glycopeptides was an important characteristic of community acquired MRSA. In the absence of other reliable phenotypic test for its identification, susceptibility to ciprofloxacin is suggested as an alternative. Conclusion: An important implication is that the typical first-line betalactams and cephalosporins will not cover the cellulitis or abscess if CA-MRSA is involved. Drug therapy will need to be changed. CA-MRSA appears to be sensitive to minocycline, doxycycline, Cotrimoxazole and clindamycin. Hence community acquired MRSA has a range of antibiotics to choose from, other than the glycopeptides, when compared with that of hospital acquired MRSA. Clinicians need to be aware of it and change according to susceptibility patterns.
Key words:- Community acquired MRSA, MecA gene, Cefoxitin, hospital acquired MRSA. |
Filename | Mathews A Anila et. al..pdf |
Filesize | 189.32 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 08/16/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 2570 Hits |
Last updated on | 09/04/2011 18:41 |
Homepage | |
CRC Checksum | |
MD5 Checksum |