Property | Value |
Name | Enhancement of Dissolution Rate and Micromeritics of Poorly Soluble Drug Ketoprofen by Liquisolid Technique |
Description | Research article:- *Vijaykumar Nagabandi1, Ramarao Tadikonda2, K.N. Jayaveera3
1.M.Pharmacy, Department of Pharmaceutics, Vaageswari College of Pharmacy, Karimnagar, A.P, India 2.M.Pharm,Ph.D, Blue Birds College of Pharmacy, Hanamkonda, India. 3.Msc.Ph.D, Jawaharlal Nehru Technological University, Ananthapur,India.
Abstract:- Liquisolid technique is novel concept for delivery of drugs through oral route. This approach of delivering drugs is mostly suitable for lipophilic drugs and poorly or water insoluble drugs. It involves dissolving water insoluble drugs in non-volatile solvents and converting into acceptably flowing and compressible powders. The main objective of present investigation was to enhance the dissolution rate of water insoluble drug ketoprofen by using liquisolid technique. Several liquisolid tablets were prepared by using different carrier materials such as microcrystalline cellulose, and dicalcium phosphate, and coating material such as silica gel, respectively. Propylene glycol and tween80 were used as non volatile water miscible liquid vehicle. The ratio of carrier to coating material was kept constant in all formulations at 20 to 1. Before compression, powdered mass were evaluated for various parameters like flow properties, content uniformity etc. All the prepared formulations were compressed using 12mm punch after addition of 5 % Sodium starch glycolate (super disintegrating agent) to each formulation. The formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, friability, drug content uniformity, and disintegration time. The in-vitro release characteristics of the pure drug, drug from marketed tablets (as reference) and liquisolid technique (test sample), were studied. X-Ray Diffraction (XRD) and Fourier-Transform infrared spectroscopy (FT-IR) were performed. The results showed that liquisolid formulations of ketoprofen exhibited good micromeritic properties and higher percentage of drug release than marketed formulation. And it was concluded that there was no interaction between drug and excipients. Keywords:- Liquisolid compacts, Ketoprofen, Dissolution, content uniformity. |
Filename | Nagabandi Vijay kumar et.al..pdf |
Filesize | 414.33 kB |
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Creator | admin |
Created On: | 08/17/2011 00:00 |
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Last updated on | 09/07/2011 02:40 |
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