Property | Value |
Name | Assessment of Therapeutic Efficacy of Chloroquine in Uncomplicated Plasmodium falciparum Malaria in a Rural area of Tripura |
Description | Research article:- * Majumdar T , Debbarma N, Roy D B. *Assistant Professor, Department of Microbiology, Agartala Government Medical College Agartala,Tripura ,India.
Abstract:- Objectives- This study was undertaken to evaluate the therapeutic efficacy of Chloroquine in uncomplicated P. falciparum malaria and to observe the pattern of drug resistance in a known Malaria endemic area in Dhalai District of Tripura, as per guidelines adopted by National Vector Borne Disease Control Programme (NVBDCP) in order to propose second line treatment in effected area. Methods-Study design was as per modified protocol for In vivo study of CQ resistance as adopted by NVBDCP. Active survey of fever cases were carried out in one Gaon Panchayet and four sub centers under Kulai Rural Health Centre of Dhalai District of Tripura, along with blood slide collection of both thick & thin film. Chloroquine administered as per body weight in P. falciparum positive cases and cases were followed up for 28 days for clinical as well as parasitological response. Results-Out of 300 slides examined 98 (32.7%) are found to be positive for malaria. Out of which Plasmodium falciparum ( Pf) ring in 78(79.6%), Pf gametocytes- 5(5.1%),Plasmodium vivax( Pv) - 10 (10.2%),Pf+Pv-5(5.1%). Total 53 cases were included in the study, out of which 40 no. of cases had complete follow up for 28 days .Early Treatment Failure (ETF) was detected in 13(32.5%) cases, Late Clinical & Parasitological Failure (LCF) was 14(35%), Adequate Clinical & Parasitological Response(ACPR) was 13(32.5%).Conclusion- Chloroquine resistant found to be 67.5%( 27/40) . Based on this study Dhalai District was declared as Drug Resistant to Chloroquine as per drug policy of NVBDCP and oral Artisunate and Sulphadoxine + Pyremethamine (ACT) combination therapy was advocated.
Keywords:- Plasmodium, Chloroquine resistance, Tripura, ETF, LCF, ACPR. |
Filename | Majumdar T et.al..pdf |
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Creator | admin |
Created On: | 09/16/2011 00:00 |
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Last updated on | 09/17/2011 03:25 |
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