Property | Value |
Name | FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE INTRAGASTRIC TABLETS OF PROPRANOLOL HYDROCHLORIDE UNSING NATURAL POLYMER |
Description | Research article:- *Dr. Mohammed M. Safhi Neuroscience and Toxicology Unit, College of Pharmacy, Jazan University, Kingdom of Saudi Arabia.
Abstract:- Floating matrix tablets of propranolol hydrochloride were developed to prolong gastric residence time and leading to an increase in drug bioavailability. Floating tablets were prepared by the wet granulation technique by using polymers such as xanthan gum and guar gum with sodium bicarbonate as a gas-generating agent. Formulation F1 and F2 have drug: xanthan gum ratios 1:0.62 and 1:1.25, F3 and F4 have drug: guar gum ratios 1:6.2 and 1:1.23, F5 and F6 have 1:0.31 and 1:0.62. The floating tablets were evaluated for uniformity of weight, hardness, thickness, friability, drug content, in vitro buoyancy and dissolution studies. In all the formulations buoyancy time ranges from 45 to 134 sec and lag time ranges from 12-24 hrs. The formulation F6 shows the floating buoyancy time 134 sec, floating lag time 24 hours and drug release 94.36%. Non-fickian diffusion was confirmed as the drug release mechanism from these tablets indicated that water diffusion and polymer rearrangement played an essential role in drug release. The formulations give the best results in terms of floating duration, prolonged drug release, and improved in vitro bioavailability. The mechanism of drug release was diffusion controlled and followed zero- order kinetics.
Key words:- Propranolol hydrochloride, xanthan gum, guar gum, in vitro buoyancy and non-fickian diffusion. |
Filename | Safhi M Mohammed.pdf |
Filesize | 439.54 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 09/16/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
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Last updated on | 10/09/2011 04:00 |
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