Property | Value |
Name | DESIGN AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF CEPHALEXIN |
Description | Research article:- *Kishore Reddy A 1, P.Prathyusha2, Krishna Reddy P 1, Naresh Kumar V 1, N.Siva Kali Prasad1
1.Department of Pharmaceutics, Centre of Pharmaceutical Sciences ,Institute of Science and Technology ,JNTUH, Hyderabad ,Andhraprdesh ,India. 2.Department of Pharmaceutics, Sree Dattha Institute of Pharmacy, Hyderabad,India.
Abstract:-The aim of this study was to develop a floating microspheres of Anti microbial drug Cephalexin by using statistical optimization technique. Microspheres were prepared by using spray drying technique. Sodium alginate and PVA were used as polymers. A Taguchi Orthogonal Array design was selected to study the effect of formulation and process parameters in the development of microspheres. The independent variables studied are percentage of drug (X1), D:P ratio (X2), P:P ratio (X3), drying inlet temperature (X4) and pump feed rate (X5). The response variables evaluated are %yield (Y1), %EE (Y2) and microspheres size (Y3). Optimization was performed by using desirability function and based on the results of optimization one optimized formula was obtained. To validate the model, the optimized formula was formulated and subjected to in-vitro characterization. Percentage yield, drug content and entrapment efficiency of optimized formula was found to be 23.21±1.21 %, 93.98 ± 1.12 %, 88.46 ± 1.33 % respectively. Drug release at the end of 8 hours of dissolution studies was found to be 89.08±0.45%. The expected values thus obtained are very close to the predicted values indicating validation of model prediction. Thus it can be concluded that Cephalexin loaded microspheres could be successfully formulated with optimized condition of spray dryer to obtain maximum percentage yield, entrapment efficiency, desired particle size and drug release. Based on the results of stability studies, it may be concluded that the so developed optimized formula was found to be stable for long period of time.
Keywords:- Cephalexin, Floating Microspheres, Poly Vinyl Alcohol, Sodium alginate, In-vitro study, Spray drying. |
Filename | Reddy Kishore A et.al.(N).pdf |
Filesize | 279.18 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 09/16/2011 00:00 |
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Maintained by | Editor |
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Last updated on | 10/12/2011 03:09 |
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