Property | Value |
Name | Assessment of Serum Malondialdehyde in Oral Squamous Cell Carcinoma patients and its association with tobacco habits |
Description | Research article:- R. Ramya, S. Prakash, S. Sudha* Molecular Diagnosis and Drug Discovery Laboratory, Department of Biotechnology, School of Life Sciences, Karpagam University, Coimbatore, Tamilnadu, India.
Abstract:-Context: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors. Its incidence is rated as one among the highest in the world and the use of tobacco in various forms is increasingly associated with the cause of OSCC. Tobacco contains many carcinogenic and mutagenic chemicals which induce the generation of free radicals and reactive oxygen species (ROS) with increased level of lipid peroxidation. Malondialdehyde (MDA) is a major lipid peroxidation product that is mutagenic and tumorigenic. Aim: To investigate the relationship between serum levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity. Methods: Serum malondialdehyde (MDA) levels in 40 histologically proven OSCC cases and 40 age matched controls were analyzed. Results and conclusion: Serum MDA levels in cancer patients were significantly higher than those in controls (P < 0.05). There was a significant association between increased MDA levels and tobacco habits. The results of this study provide further evidence that there is relationship between serum MDA and OSCC. The study hypothesizes that oxidant/antioxidant imbalance may be one of the major factor responsible for the development of oral cancer.
Key words:- Oral squamous cell carcinoma, Malondialdehyde, Lipid peroxidation. |
Filename | Sudha_S_et._al..pdf |
Filesize | 115.56 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 09/16/2011 00:00 |
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Last updated on | 10/12/2011 15:48 |
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