Property | Value |
Name | Effect of a topical curcumin preparation (BIOCURCUMAX) on burn wound healing in rats |
Description | Research Article:- *S.Durgaprasad1, Rai Reetesh2 , Kumar Hareesh2, Ravindrasingh Rajput2 1.Dept. of Pharmacology, American university of Antigua, College of medicine, Antigua. 2.Department of pharmacology, Kasturba Medical College, Manipal University, Manipal,India.
Abstract :- Back ground: Curcumin, a naturally occurring o-methoxyphenol derivative, has been shown to possess several biological properties including antioxidant (free radical scavenging activity), induction of detoxification enzymes and provides protection against degenerative diseases. Topical applications of compounds with free radical scavenging properties in patients have shown to improve significantly wound healing and protect tissues from oxidative damage. Objectives: To assess the effect of a topical curcumin preparation on healing of partial thickness burn wounds in rats. Methods: The rats are randomly divided into four groups, comprising of six rats in each group. Partial thickness burn wounds are created by pouring hot molten wax at 80ºC. Group I acts a control, Group 2 receives the standard silver sulphadiazine cream, Group 3 gets 20% curcumin cream, and Group 4 receives the combination of the dexamethasone and curcumin cream. Parameters observed are epithelialization period and wound contraction. Results & Discussion: The percentage of wound contraction was significantly increased in the topical curcumin preparation (20%) and silver sulfadiazine group compared to control group. The mean period of epithelization was significantly reduced in topical curcumin preparation (20%) group and silver sulfadiazine group as compared to the control. Conclusion: Topical curcumin preparation is effective in healing burn wound and the effect was comparable to that of standard drug i.e. silver sulfadiazine.
Keywords:- Topical curcumin, burn wound, epithelization period, wound contraction. |
Filename | Durgaprasad S et. al..pdf |
Filesize | 210.33 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 07/18/2011 00:00 |
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Last updated on | 11/08/2011 08:39 |
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