Property | Value |
Name | A Study of Transdermal Delivery of Captopril Using Iontophoresis |
Description | Research article:- *Ashish Jain1, Satish Nayak2, Vandana Soni3 * 1 M.Pharm, Assistant Professor, Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India. 2.Ph.D., Director, Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India. 3.Ph.D., Professor, Department of Pharmaceutical Sciences, Dr H.S.Gour Vishwavidyalaya, Sagar 470003, M.P. India.
Abstract:- The pupose of the present work was to assess iontophoretic transdermal delivery of Captopril across pigskin for its transdermal development. In vitro iontophoretic transdermal delivery of Captopril across the pigskin was investigated at three different drug concentrations and tree different current densities (0.25- 075 mA/cm2 ) in the donor cell of the diffusion apparatus, using cathodal iontophoresis along with the passive controls. For passive permeation, the steady state flux significantly increased with the donor drug concentration. At all concentration levels, iontophoresis considerably increased the permeation rate compared to passive controls. Iontophoretic transport of Captopril was to be found with current densities. Flux enhancement was highest at the lowest drug load and lowest at the highest drug load. We concluded permeation rate of drugs across the pigskin can be considerably enhanced by the use of Iontophoresis.
Keywords: Captopril; Iontophoresis; Pigskin; Transdermal drug delivery. |
Filename | Jain Ashish et al..pdf |
Filesize | 195.66 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 10/16/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 4105 Hits |
Last updated on | 11/13/2011 19:15 |
Homepage | |
CRC Checksum | |
MD5 Checksum |