Property | Value |
Name | Formulation and characterization of floating tablets of Diltiazem hydrochloride |
Description | Research article:- *Ara N. Patel1, Falguni M. Patel1, Kamal Singh Rathore1 . 1Bhupal Nobles’ Girls’ College of Pharmacy, Department of Pharmaceutics, Udaipur-313002, Rajasthan, India.
Abstract:- The purpose of the present study was to develop an optimized floating drug delivery system of diltiazem hydrochloride. Diltiazem floating tablets were formulated with different concentrations of two grades of HPMC polymers (HPMC K4M and HPMC K100M) by using wet granulation technique and evaluated for the different evaluation parameters such as thickness, diameter, drug content uniformity, friability, floating lag time, in-vitro buoyancy, in-vitro drug release studies and stability studies were performed. All the evaluation parameters results were significant. In-vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow both Higuchi and Korsemeyer and Peppas’ equation. The drug release mechanism was found Fickian type in most of the formulations. The prepared formulation shows better and significant results for all the evaluated parameters. The formulation A4 containing (HPMC K 4 M) shows maximum percentage of drug release (99.87 %) and prolonged release for time period of about 12 h, thereby improves the bioavailability and patient compliance.
Key words :- Floating drug delivery system, Diltiazem HCl, Buoyancy period, Higuchi plots, Accelerated stability studies. |
Filename | Patel N Ara et.al..pdf |
Filesize | 702.28 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 08/16/2011 00:00 |
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Maintained by | Editor |
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Last updated on | 11/14/2011 07:57 |
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