Property | Value |
Name | Investigation of Polymorphic behaviour of Rizatriptan |
Description | Research article:- * Rahul Nair 1, Sevukarajan.M 1, Ravi Kumar. 1.Department Of Pharmaceutics, Sree Vidyanikethan College of Pharmacy,A.Rangampet, Tirupathi, Andhrapradesh, India.
Abstract :- The main objective of this study was to investigate polymorphic behavior of rizatriptan benzoate (RTB) The polymorphs were prepared by solvent evaporation method, by using various solvents like Polyvinyl pyrrolidine ,Tween 80 , Methanol and Polyethylene glycol .We have prepared four different polymorphs of RTB (Form I, Form II, Form III and Form IV). RTB polymorphs were characterized by infra-red absorption spectrum, differential scanning calorimetry, scanning electron microscopy and dissolution studies. It was observed that there was a significant change in the melting point between Form I and Form II when compared with RTB. Rizatriptan benzoate polymorphs prepared with TW 80 showed better dissolution. The mechanism of drug release was analyzed using zero order, first order, Peppas and, Hixson-Crowell models.
Key words:- Rizatriptan Benzoate, Polymorphs, Dissolution profiles |
Filename | Nair Rahul et.al..pdf |
Filesize | 455.4 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 10/17/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
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Last updated on | 11/21/2011 08:46 |
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