Property | Value |
Name | Formulation and Evaluation of Trimetazidine Sustained Release Capsules |
Description | Research article:-*Swapna Velivela 1, Sashmitha Samuel.B1, V. Asha Ranjani1, P.Muthuprasanna2. 1MLR Institute of Pharmacy, Dundigal (V), Quthbullapur (M), Hyderabad-43, Andhra Pradesh, India. 2.Hindu college of Pharmacy, Guntur-522002, A.P , India.
Abstract:-Trimetazidine (TMZ) is an effective and well tolerated anti-anginal drug that possesses protective properties against ischemia- induced heart injury. However it has a short coming of a shorter half-life. Hence, in the present investigation extended release pellets of Trimetazidine hydrochloride (TMZ) were prepared using ethyl cellulose polymers to achieve a prolonged therapeutic action by continuously releasing medication over an extended period of time after administration of a single dose. The sustained release formulations were optimized by employing suspension / solution layering technique. The drug release characteristics of all the formulations were evaluated by HPLC technique and stability studies were carried out for about three months at different temperature and humidity conditions.
Key words:- Ethyl cellulose (EC), Sustained release (SR), Trimetazidine (TMZ) |
Filename | Velivela Swapna et.al..pdf |
Filesize | 324.44 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 11/16/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
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Last updated on | 12/17/2011 08:06 |
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